A bilateral cornual uterine dehiscence is reported, which occurred 14 weeks after in-vitro fertilization (IVF) in a patient having a medical history of previous bilateral salpingectomy via laparoscopy. Uterine rupture is a rare obstetric complication usually occurring during the third trimester of pregnancy within a uterus which has previously undergone an operation. Ectopic pregnancy is a well known complication of IVF. Post-salpingectomy cornual localization with rupture has also been published. Possible causes are discussed and the attention of the counselling physician is directed to the necessary awareness of such a complication in this high risk population. The reported case is an extreme rarity: a similar case has not been previously published in the literature.

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Poly(adenosine diphosphate-ribose) polymerases (PARPs) are a family of enzymes, which catalyses poly (ADP-ribosyl)ation of DNA-binding proteins and directly involved in genomic stability, DNA repair, and apoptosis. In this study, we evaluated the immunomorphology of PARP-1 in melanoma and its prognostic importance. We studied PARP-1 expression by immunohistochemistry in a selected series of 54 primary cutaneous malignant melanoma (CMM). The findings of the present study suggest that the neoplastic progression toward the invasive (both horizontal and vertical) growth phase of CMM cells is characterized by the loss of cleavage of PARP-1, probably signaling an imbalance of the apoptotic process in these cells and leading to further gain to aggression. Over-expression of full-length PARP-1 was correlated with recurrence and/or progression of the disease and so act as a promising new biological marker of CMM. Our study represents the evidence of a direct correlation between the PARP-1-mediated apoptotic process and the biologic behavior of CMM.

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A melanoma malignum kezelésében a korábbi mechanikus szemléletet felváltotta az ún. biológiai szemlélet, melynek során a szervezet tumorellenes mechanizmusait igyek szünk támogatni. Ez a szemléletváltás a melanoma sebészeti kezelésben a primer tumor körüli biztonsági zóna lecsökkentéséhez és az őrszem (sentinel) nyirokcsomó biopszia bevezetéséhez vezetett. A melanoma terápiájában manapság a sebészre négy meghatározó feladat hárul: a primer tumor eltávolítása, sentinel nyirokcsomó biopszia valamint blokkdisszekció elvégzése és a bőrmetasztázisok sebészi ellátása. Jelen összefoglaló közleményben a szerzők a legfrissebb nemzetközi irányelvek, tudományos eredmények és saját gyakorlatuk alapján részletes áttekintést nyújtanak a melanoma műtéti ellátásáról, beszámolnak a nem rezekábilis bőráttétek kezelésében hasz nálatos új eljárásról, a hazánkban is elérhető elektrokemoterápiáról. Kulcsszavak: melanoma malignum-biztonsági zónasentinel nyirokcsomó-blokkdisszekció-elektrokemoterápia SUMMARY Recently the biological approach dominates in the treatment of malignant melanoma, which means the support of the antitumor defense of the organism. This view has led to diminished safety margins at the removal of the primary tumor and introduction of sentinel lymph node biopsy. Nowadays surgeons have four main tasks in the treatment of melanoma: excision of primary tumor, sentinel lymph node biopsy, regional lymph node dissection, and surgical treatment of the metastases. Based on the latest international guidelines, published data, and best practices authors summarize the current surgical therapies of cutaneous malignant melanoma, and also account on electrochemotherapy, which is a new, effective treatment of the irresecable cutaneous metastases.