Incidence of ocular conditions associated with perfluoroalkyl substances exposure: Isomers of C8 Health Project in China

Zeeshan, Mohammed; Yang, Yunqing; Zhou, Yang; Huang, Wenxiu; Wang, Zhibin; Zeng, Xiao; Liu, Ru Qing; Yang, Bo; Hu, Li; Zeng, Xiao Wen; Sun, Xiao; Yu, Yunjiang; Dong, Guang‐Hui

doi:10.1016/j.envint.2020.105555

Cited by 39 publications

(28 citation statements)

References 64 publications

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“…Human exposure to legacy PFAS has been investigated worldwide. Available data indicate that despite of the restriction of PFOA and PFOS, they remain dominated over other PFAS in humans from most regions, − reflecting a consequence of long-term and extensive applications as well as their bioaccumulative nature. In line with previous findings, , our data indicated that Shanghai residents could face elevated PFAS exposure compared with other studies.…”

Section: Resultsmentioning

confidence: 99%

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples

Liu

Luo

Zhang

et al. 2022

Environ. Sci. Technol.

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Exploration of the exposure of preconception couples to per- and polyfluoroalkyl substances (PFAS), as well as the most important influencing factors, promotes the understanding of the joint effects of parental exposure on reproductive health. In the present study, a total of 938 preconception couples recruited through the Shanghai Birth Cohort were investigated for the variations of PFAS exposure and contributing factors within and between couples. While linear perfluorooctanoic acid (n-PFOA, median 20.4 ng/mL) and linear perfluorooctanesulfonic acid (n-PFOS, 12.1 ng/mL) remained dominant in plasma, emerging PFAS, particularly 6:2 chlorinated polyfluorinated ether sulfonate (10.5 ng/mL), 6:2 polyfluoroalkyl phosphate diester (0.41 ng/mL), and branched PFOS or PFOA isomers, were also frequently detected. Although individual PFAS were generally correlated within couples, gender differences significantly existed in the concentrations of most individual PFAS and isomer profiles of PFOS and PFOA. Men generally exhibited higher plasma concentrations than their partners, likely reflecting gender-specific elimination pathway and kinetics. Couple-based PFAS exposure also varied greatly. After adjustment for individual factors, several household factors, including annual household income, dwelling floor type, drinking water source, and living near farmlands, were found to be associated with couple-based PFAS exposure. Our study constitutes one of the few studies addressing couple-based exposure to PFAS and lays a solid ground for further assessment of the impacts of parental exposure on reproductive health.

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Section: Resultsmentioning

confidence: 99%

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples

Liu

Luo

Zhang

et al. 2022

Environ. Sci. Technol.

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“…Huo et al did not find a significant and consistent pattern of association with PFAS exposure and gestational hypertension, preeclampsia, or hypertensive disorders of pregnancy [10]. Associations between PFAS body burden and visual impairment diseases in China and increased risk of breast cancer, particularly among younger Taiwanese women were also found [15,18].…”

Section: Chinamentioning

confidence: 97%

“…Among Chinese adults, Zeeshan et al observed that blood levels of PFASs were significantly higher in a group with eye disease when compared to a group without such disease. A recent study found evidence suggesting an association between PFAS and uric acid varied according to adult kidney function and isomer [15].…”

Section: General Populationsmentioning

confidence: 99%

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Per and polyfluoroalkyl substances scientific literature review: water exposure, impact on human health, and implications for regulatory reform

Chohan

Petaway

Rivera-Diaz

et al. 2020

Reviews on Environmental Health

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Among other emerging contaminants in water, per and polyfluoroalkyl substances (PFASs) have garnered international attention from the scientific community on a global scale. Some countries, such as the United States, have found that PFASs are present in humans on a wide scale. Although two PFASs have been widely studied-Perfluorooctanoic acid and Perfluorooctanesulfonic acid-many more PFASs are being created by industry and are either not known, not studied, or both. The objective of this literature review on PFASs is to give an overview of the information available about PFASs related to human exposure. The information from this literature review on the exposure of humans to PFASs through drinking water and the lack of many conventional drinking water treatment systems' ability to remove PFASs (particularly short-chain PFASs) suggests that current regulatory limits are insufficient to adequately protect humans. This is especially true for particularly vulnerable populations such as infants, young children, and developing children (pubescent). The gaps in the current knowledge and in current regulatory approaches could have long-term effects on human health.

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“…The eye is highly sensitive to various environmental agents [1][2][3]. International standardization bodies set the limits for non-ionizing radiation, especially for wavelengths less than 1 mm, based on eye safety [4].…”

Section: Introductionmentioning

confidence: 99%

Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents

Kodera

Hirata

Miura

et al. 2020

Computers in Biology and Medicine

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Incidence of ocular conditions associated with perfluoroalkyl substances exposure: Isomers of C8 Health Project in China

Cited by 39 publications

References 64 publications

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples

Per and polyfluoroalkyl substances scientific literature review: water exposure, impact on human health, and implications for regulatory reform

Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents

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