Incidence of pediatric Horner syndrome and the risk of neuroblastoma: A population-based study

Smith, Stephen J.; Diehl, Nancy N.; Leavitt, Jacqueline A.; Mohney, Brian G.

doi:10.1016/j.jaapos.2009.12.033

Cited by 12 publications

(20 citation statements)

References 17 publications

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“…No obstante, se han reportado casos secundarios a timo ectópico cervical, malformación vascular, neuroblastoma congénito y varicela congénita. [1][2][3][4] El paciente presentado no tiene antecedentes perinatológicos y su madre refiere haber notado la ptosis palpebral y la heterocromía del iris del ojo derecho desde el nacimiento.En cuanto al síndrome de Horner adquirido (SHA), dentro de sus causas se encuentran intervención, trauma, neoplasia, infección y malformación vascular. 4 A su vez, existen casos idiopáticos, tanto congénitos como adquiridos.…”

Section: Discussionunclassified

“…[1][2][3][4] El paciente presentado no tiene antecedentes perinatológicos y su madre refiere haber notado la ptosis palpebral y la heterocromía del iris del ojo derecho desde el nacimiento.En cuanto al síndrome de Horner adquirido (SHA), dentro de sus causas se encuentran intervención, trauma, neoplasia, infección y malformación vascular. 4 A su vez, existen casos idiopáticos, tanto congénitos como adquiridos. 4 Además, se han descrito casos de síndrome de Horner intermitente, el cual se asoció a la cefalea en racimos y a lesiones de la médula espinal.…”

Section: Discussionunclassified

“…4 A su vez, existen casos idiopáticos, tanto congénitos como adquiridos. 4 Además, se han descrito casos de síndrome de Horner intermitente, el cual se asoció a la cefalea en racimos y a lesiones de la médula espinal. 5 En ocasiones, el paciente presenta otros hallazgos asociados al síndrome de Horner que orientan el diagnóstico etiológico.La mayor dificultad se da en aquellos pacientes en los que el examen físico no brinda información suficiente para localizar la lesión.…”

Section: Discussionunclassified

“…Este último es el tumor sólido extracraneal más común en niños menores de 5 años. 4 Su localización más frecuente es abdominal (60%), seguida de torácica (15%), pelviana (5%) y cervical (5%). 6 La localización de la lesión de la vía simpática mediante el uso de pruebas farmacológicas es útil en adultos, pero, en pacientes pediátricos, puede arrojar resultados equívocos.…”

Section: Discussionunclassified

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Síndrome de Horner congénito. Caso clínico

Olivera

FernándezI

Arias

et al. 2018

Arch Argent Pediatr

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RESUMENEl síndrome de Horner está caracterizado por la siguiente tríada de signos clínicos: miosis, ptosis y anhidrosis facial. A su vez, pueden aparecer heterocromía del iris, inyección conjuntival, eritema facial, mucosa nasal congestiva y enoftalmos aparente secundario a la disminución de la hendidura palpebral. Es causado por una interrupción de la vía simpática, que se extiende desde el hipotálamo hasta la órbita. Debido a que dicha vía no se decusa, los signos son homolaterales a la lesión de esta. Tradicionalmente, se lo clasifica en congénito y adquirido. En ocasiones, se asocia a neoplasias, como el neuroblastoma. Sigue siendo controversial qué estudios de imágenes se deberían solicitar en forma protocolizada frente a un paciente con este síndrome neurológico. Se presenta el caso de un lactante de 45 días de vida con síndrome de Horner congénito. Palabras clave: síndrome de Horner, neuroblastoma. ABSTRACTHorner syndrome is characterized by the following triad of clinical signs: miosis, ptosis and facial anhidrosis. In addition, iris heterochromia, conjunctival injection, facial erythema, congestive nasal mucosa and apparent enophthalmos secondary to the reduction of the palpebral fissure can appear. It is caused by an interruption of the sympathetic pathway that extends from the hypothalamus to the orbit. Because there is no decussation, the signs are homolateral to the lesion. Traditionally, it is classified as congenital and acquired. Occasionally, it is associated with neoplasias such as neuroblastoma. It remains controversial what imaging studies should be requested as a protocolized workup of this neurological syndrome in a patient. We report the case of a 45-day-old infant with congenital Horner syndrome.

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Síndrome de Horner congénito. Caso clínico

Olivera

FernándezI

Arias

et al. 2018

Arch Argent Pediatr

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“…The lesion can occur anywhere along the three-neuron tract, from its central origin to the innervation of the orbit 1. Miosis and ptosis are the main clinical signs of HS, although iris heterochromia, pupillary dilation and anydrosis may also be seen 1…”

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confidence: 99%

Ptosis, miosis and cats

Santo¹,

Salgado

Prata

et al. 2017

BMJ Case Reports

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Horner's syndrome (HS) is caused by a disruption in the oculosympathetic pathway. Both congenital and acquired HS are unusual in children. Acquired HS can be caused by trauma, surgical intervention, tumours, vascular malformations or infection.We describe the case of a 6-year-old boy who was brought to our emergency department with ptosis, miosis, painful cervical lymphadenopathy and a cat scratch on a hand. The diagnosis of a cat scratch disease was confirmed by serology. A full recovery was observed on antibiotic treatment and cervical lymphadenomegaly reduction 3 weeks later.

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Nationwide population-based incidence and etiologies of pediatric and adult Horner syndrome

2020

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Purpose To determine age-and sex-specific incidence and possible etiologies of pediatric and adult Horner syndrome in South Korea. Methods A nationwide, population-based, cohort study using data from the Korean National Health Claims database from 2007 to 2018. All patients with Horner syndrome from the entire Korean population (n = 51,629,512) were included. To find possible causes of Horner syndrome, we searched concurrent codes for systemic diseases, trauma, or surgical procedures. Results A total of 139 pediatric patients (59.7% male) and 1331 adults (51.0% male) were newly diagnosed as having Horner syndrome. The cumulative incidence was 2.12 (95% CI 2.08-2.17) per 100,000 pediatric population and 2.95 (2.94-2.96) per 100,000 adults. The peak incidence occurred at 0-4 years of age in the pediatric population, and at 50-54 years in the adult population. A total of 835 (56.8%) patients had underlying conditions or related surgical procedures associated with Horner syndrome. The underlying causes were recognized in 695 (83.2%) patients before the diagnosis of Horner syndrome, in 75 (9.0%) patients at the same time as the Horner syndrome diagnosis, and in 65 (7.8%) patients after the diagnosis of Horner syndrome. There were four cases of Horner syndrome that preceded neuroblastoma diagnosis. The most common tumor related with Horner syndrome was that of the thyroid in the adult population. Conclusions This study determined the estimated incidence and possible causes of pediatric and adult Horner syndrome. As Horner syndrome with unknown etiologies may harbor serious malignancy, extensive evaluations are required, especially in children.

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Incidence of pediatric Horner syndrome and the risk of neuroblastoma: A population-based study

Cited by 12 publications

References 17 publications

Síndrome de Horner congénito. Caso clínico

Síndrome de Horner congénito. Caso clínico

Ptosis, miosis and cats

Nationwide population-based incidence and etiologies of pediatric and adult Horner syndrome

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