Incidence of Peters Anomaly and Congenital Corneal Opacities Interfering With Vision in the United States

Kurilec, J.M.; Zaidman, Gerald W.

doi:10.1097/ico.0000000000000182

Cited by 57 publications

(47 citation statements)

References 11 publications

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“…These anomalies cause visual loss through obstruction of vision axis [Weh et al, ]. Peters anomaly can be isolated or associated with systemic defects [Kurilec and Zaidman, ; Weh et al, ], including chromosomal abnormalities as 22q11 deletion syndrome [Kurilec and Zaidman, ] and cri–du–chat syndrome [Hope et al, ]. In our literature review, we did not find descriptions of patients with trisomy 18 and Peters anomaly, as observed in our sample.…”

Section: To the Editormentioning

confidence: 46%

“…Peters anomaly is a major cause of congenital corneal opacity [Kurilec and Zaidman, ; Hope et al, ; Ni et al, ]. It is a rare form of anterior segment dysgenesis in that the corneal haze may or may not be accompanied by iridocorneal adhesions and associated defects in the subsequent cornea layers [Weh et al, ; Hope et al, ].…”

Section: To the Editormentioning

confidence: 99%

“…It is a rare form of anterior segment dysgenesis in that the corneal haze may or may not be accompanied by iridocorneal adhesions and associated defects in the subsequent cornea layers [Weh et al, ; Hope et al, ]. Another feature is the absence of Descemet's membrane and endothelium in the opacity area [Kurilec and Zaidman, ; Hope et al, ; Ni et al, ]. These anomalies cause visual loss through obstruction of vision axis [Weh et al, ].…”

Section: To the Editormentioning

confidence: 99%

See 2 more Smart Citations

Trisomy 18 and eye anomalies

Correia

Rosa

Silveira

et al. 2016

American J of Med Genetics Pt A

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Section: To the Editormentioning

confidence: 46%

Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

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Trisomy 18 and eye anomalies

Correia

Rosa

Silveira

et al. 2016

American J of Med Genetics Pt A

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“…Childhood glaucoma encompasses cases of primary congenital glaucoma (PCG) and glaucoma with nonacquired ocular anomalies (Thau et al, 2018). These conditions are rare, with prevalences ranging from 1 in 10,000 (PCG) to 1 in 100,000 (Peters anomaly; Kurilec & Zaidman, 2014) live births. Two diagnostic differences between these groups are whether glaucoma co-occurs with ocular defects and the timing of glaucoma presentation.…”

Section: Introductionmentioning

confidence: 99%

Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study

Moore

Carmichael

Forestieri

et al. 2020

Birth Defects Research

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Primary congenital glaucoma (PCG) and anterior segment defects (ASDs) are rare ocular malformations diagnosed early in life which can cause blindness. Pathogenic variants in several genes have been linked to these conditions, but little is known about nongenetic risk factors. We investigated the association between maternal nutrition and PCG and ASDs in the National Birth Defects Prevention Study, a large population‐based, multicenter case–control study of major birth defects in the United States. Mothers of cases (n = 152) and control infants without a birth defect (n = 9,178) completed an interview which included a food frequency questionnaire capturing usual dietary intake in the year before pregnancy. Maternal nutrition was assessed through individual nutrient intake, calculating a Diet Quality Index for Pregnancy (DQI‐P) score for each mother, and using latent class analysis to empirically derive four dietary patterns. We calculated adjusted odds ratios (aORs) and 95% confidence intervals (CI) using logistic regression. The results for individual nutrients varied, with some having an inverse or U‐shaped pattern of association with increasing intake. The DQI‐P was not associated with risk of PCG and ASDs (aOR 0.91; CI 0.49–1.66, highest vs. lowest quartile). The dietary pattern analysis suggested lower odds among women with a Prudent and Mexican dietary pattern (aOR 0.82, 95% CI 0.52–1.29; aOR 0.80, 95% CI 0.36–1.78, respectively) compared to those with a Western dietary pattern. We found that higher intake of some nutrients and certain dietary patterns may be inversely associated with PCG and ASDs, though caution is urged due to imprecision of estimates.

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“…Although the exact prevalence of Peters anomaly is unknown, Kurilec et al have described the prevalence of disorders known as congenital corneal opacities as affecting 1 individual per 24 000 1 . While most cases of Peters anomaly are sporadic, it can be inherited in an autosomal dominant (FOXC1, 2 PAX6, 3 and PITX2 4 ) or recessive (CYP1B1) manner via the aforementioned gene mutations.…”

Section: Introductionmentioning

confidence: 99%

Peters anomaly: A 5‐year experience

Salik

Gupta

Tara

et al. 2020

Pediatric Anesthesia

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Background Peters anomaly is a rare, congenital eye malformation characterized by an opaque cornea and blurred vision. Central corneal opacification can lead to delayed progression of visual development caused by defects in Descemet membrane and the posterior stroma. These children require several anesthetics for multiple eye examinations under anesthesia and corneal transplantation. Aims We sought to review the anesthetic management of patients with Peters anomaly for ophthalmologic procedures at Westchester Medical Center, a major referral center for Peters anomaly. Methods A retrospective chart review was completed which included pediatric patients who underwent ophthalmologic procedures related to Peters anomaly from 2013‐2018. Results The charts of 35 patients with Peters anomaly were reviewed: 14 patients with Peters anomaly Type I, 10 patients with Peters anomaly Type II, and 11 patients with Peters plus syndrome. Thirty patients required three procedures on average, two examinations under anesthesia pre‐ and post‐transplant, and anesthesia for the corneal transplant itself. The youngest patient encountered for examination under anesthesia was 39‐week postconceptual age. Anesthetic time for examination under anesthesia averaged 31 minutes using a laryngeal mask airway while corneal transplant averaged 104 minutes utilizing endotracheal intubation. Postanesthesia care unit stay averaged 51 minutes following examination under anesthesia and 65 minutes after corneal transplant. All examinations under anesthesia were successfully completed without adverse events with the use of a laryngeal mask airway. This case series includes two patients with Goldenhar syndrome and Al‐Gazali syndrome accompanying Peters anomaly. Conclusion Although limited by its retrospective nature, this case series describes the cardiac and systemic implications of patients undergoing anesthesia with Peters anomaly. Our experience indicates that general anesthesia and airway manipulation are tolerated with minor postoperative concerns in these infants. Pediatric patients with Peters anomaly require multiple anesthetics for repeated ophthalmologic interventions. The laryngeal mask airway can be routinely utilized in infants less than 3 months of age for an eye examination under anesthesia with no airway complications noted. Perioperative providers should be aware of the multisystemic implications in patients with Peters plus syndrome.

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Incidence of Peters Anomaly and Congenital Corneal Opacities Interfering With Vision in the United States

Cited by 57 publications

References 11 publications

Trisomy 18 and eye anomalies

Trisomy 18 and eye anomalies

Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study

Peters anomaly: A 5‐year experience

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