Incidence of Post-Transfusion Hepatitis before and after Screening for Hepatitis C Virus Antibody

Wang, Yuan‐Jen; Lee, Shou‐Dong; Hwang, Shinn‐Jang; Chan, Cho‐Yu; Chow, Mo‐Ping; Lai, Shiau Ting; Lo, Kwang‐Juei

doi:10.1159/000462587

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…As HCV infection is traditionally transmitted via the blood, post-transfusion hepatitis due to HCV infection accounts for the high rates of hepatitis in this setting [Alter et al, 1989;Esteban et al, 1990;Aach et al, 1991;Lee et al, 1991b;Watanabe et al, 1994]. However, since the implementation of specific testing for anti-HCV in donated blood, transmission by blood products was effectively reduced [Donahue et al, 1992;Wang et al, 1994Wang et al, , 1995. Our case-control study showed that a history of blood transfusion was related significantly to anti-HCV seropositivity, as has been documented in previous studies of blood transfusion recipients [Alter et al, 1989;Esteban et al, 1990;Aach et al, 1991].…”

Section: Discussionmentioning

confidence: 99%

Transmission of hepatitis C virus in Taiwan: Prevalence and risk factors based on a nationwide survey

et al. 1999

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A nationwide community-based survey on hepatitis C virus (HCV) was carried out in seven townships in Taiwan. A total of 11,904 men aged 30-64 years were recruited for testing for antibodies against HCV (anti-HCV) by second-generation enzyme immunoassay. A total of 272 seropositive cases and 282 seronegative controls were interviewed to explore risk factors for HCV infection in the study areas. Spouses of 214 seropositive cases were identified to assess the concordance of seropositivity of anti-HCV between spouses; genotypes of HCV were also tested in 26 couples who were both seropositive. A significant geographic variation in seroprevalence of anti-HCV was observed in the study townships (1.6-19.6%). Blood transfusions, medical injections, acupuncture and tattooing were related to an increased anti-HCV seroprevalence showing multivariate-adjusted odds ratios of 8.6, 2.5, 3.1, and 2.2, respectively, with corresponding population attributable risk percentages of 25%, 57%, 16%, and 3%, respectively. The anti-HCV prevalence in spouses of index cases (24%) was significantly higher than that observed in the general population of the study areas (4%). However, a striking interspousal discrepancy in HCV genotypes (20/26 = 77%) was observed among both seropositive couples. Common exposures to medical injections and acupuncture were reported by 15 (58%) of these couples. This study identified some endemic areas of HCV infection in Taiwan. Iatrogenic factors were common vehicles for HCV infection, and a concordance of anti-HCV seropositivity between spouses may primarily be due to extrafamilial iatrogenic infectious sources in study areas.

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Section: Discussionmentioning

confidence: 99%

Transmission of hepatitis C virus in Taiwan: Prevalence and risk factors based on a nationwide survey

et al. 1999

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“…Quando comparamos os grupos com os resultados de HCV-RNA, observamos que o único paciente do grupo após 1993 é negativo. Nossos dados também são semelhantes aos encontrados por Makris et al 28 e Wang et al 34 , que demonstraram maior presença de infecção pelo HCV em hemofílicos que iniciaram tratamento em data anterior à triagem sorológica obrigatória para HCV, quando comparados com os que iniciaram tratamento após. Na nossa amostra não houve pacientes com viremia para HCV (HCV-RNA positivo) após o início da triagem obrigatória de doadores.…”

Section: Discussionunclassified

Hepatitis C virus (HCV) in children and adolescent hemophiliacs

Succi¹,

Bensabath²,

Soares³

et al. 1998

J Pediatr (Rio J)

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IntroduçãoO efeito indesejável mais notório das transfusões sangüíneas é a aquisição de hepatites virais. As múltiplas exposições dos hemofílicos ao uso de derivados do sangue colocam este grupo em extremo risco na aquisição destas hepatites. Comprovadamente implicados nas hepatites pós-transfusionais, desenvolvidas pelos hemofílicos, ResumoObjetivo: Avaliar a soroprevalência de infecção pelo HCV entre hemofílicos no Estado do Pará e a possível relação com nível sérico de enzimas hepáticas, tipo de hemofilia, idade, gravidade, combinação e tipo de tratamento e data de início de tratamento com hemoderivados.Métodos: Estudo epidemiológico com corte transversal, analisando 62 pacientes hemofílicos do Centro de Hemoterapia do Pará (HEMOPA), nascidos a partir de 01/01/80, através de revisão de prontuário, exame físico e exames laboratoriais: Anti-HCV (ELISA 3ª geração), Reação de cadeia de polimerase -PCR -(HCV-RNA )e dosagem de níveis séricos de transaminases (ALT e AST) . A análise estatística dos dados foi feita aplicando os testes do qui-quadrado e o teste exato de Fisher, considerando-se significantes os resultados de p< 0,05.Resultados: Dos 62 pacientes analisados, 48,4% (n=30) eram soropositivos para o HCV. Dentre estes pacientes, 43,3% (n=13) apresentavam viremia com detecção de RNA viral pela técnica de PCR. A infecção pelo HCV se relacionou com data de início de tratamento anterior a 1993(p= 0,0005); com o tipo de hemofilia, sendo o tipo A mais freqüente (p=0,028); com gravidade, sendo mais freqüente na forma moderada (p=0,026); e com faixa etária, sendo mais freqüente acima dos 5 anos de idade (p=0,025).Conclusões: A infecção pelo HCV entre hemofílicos no Estado do Pará é elevada (48,4%) e se relacionou com início de tratamento anterior a 1993, quando se iniciou a triagem sorológica obrigatória para HCV nos bancos de sangue no Brasil. É também significantemente mais freqüente entre crianças com idade superior a 5 anos, com hemofilia do tipo A e com hemofilia de gravidade moderada. J. pediatr. (Rio J.). 1998; 74(4): 325-332:hepatite, hemofilia, doença de Christmas. AbstractObjective: To evaluate the prevalence of infection by HCV among hemophiliacs in the State of Pará (Brazil), and its possible relation to hepatic enzymes serum level, type of hemophilia involved, age, level of severity, kinds and combinations of treatment, as well as date in which treatment with hemoderivates was started.Methods: Cross-sectional epidemiological investigation, analyzing 62 hemophilic patients of the Centro de Hemoterapia do Pará (HEMOPA), all born after 01/01/80, by means of the review of the medical records, physical examination and laboratory tests: Anti-HCV (ELISA 3.0), polymerase chain reaction -PCR -(HCV-RNA), and dosage of transaminases serum levels. Statistical analysis was carried out using Chi-square and Fisher's Exact Test, the results being considered significant if p<0.05.Results: Out of the 62 patients analyzed, 48.4% (n=30) were HCV positive. Among these patients, 43.3% (n=13) presented viraemia with detectio...

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“…A sharp drop in post-transfusional hepatitis C was obser ved since the state-of-the-art screening assays of HCV antibodies were applied to blood donors [4,5] . However, patients of post-transfusion and sporadic hepatitis C infection were still reported for the presence of preseroconversion window period (PWP), in which antibody detection was not able to identify subjects in the early stage of infection.…”

Section: Introductionmentioning

confidence: 99%

Detection of hepatitis C virus core antigen for early diagnosis of hepatitis C virus infection in plasma donor in China

Zhang¹,

Li²,

Wang³

et al. 2007

WJG

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AIM:To evaluate the efficacy of a new hepatitis C virus (HCV) core antigen assay developed in China. METHODS:After the determination of HCV infection, 49 serial samples were selected from 11 regular plasma donors in 5 different plasma stations. To compare the performance of HCV core antigen detection and HCV PCR, these samples were genotyped, and each specimen was analyzed by ELISA for the detection of HCV core antigen and by qualitative HCV PCR. RESULTS:Among all of the sequential samples, the original 13 specimens were HCV RNA-negative, and 36 samples were HCV RNA-positive. Twenty-seven samples (75%) were HCV core antigen-positive from these HCV RNA-positive specimens. Conversely, 27 samples (93.1%) were found HCV RNA-positive in HCV core antigenpositive samples. Intervals between HCV RNA and HCV core antigen-positive, as well as between HCV core antigen-positive and HCV antibody-positive were 36.0 and 32.8 d, respectively. CONCLUSION:This HCV core antigen assay, developed in China, is able to detect much of anti-HCV-negative, HCV RNA-positive preseroconversion window period (PWP) plasma donations.

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Incidence of Post-Transfusion Hepatitis before and after Screening for Hepatitis C Virus Antibody

Cited by 6 publications

References 10 publications

Transmission of hepatitis C virus in Taiwan: Prevalence and risk factors based on a nationwide survey

Transmission of hepatitis C virus in Taiwan: Prevalence and risk factors based on a nationwide survey

Hepatitis C virus (HCV) in children and adolescent hemophiliacs

Detection of hepatitis C virus core antigen for early diagnosis of hepatitis C virus infection in plasma donor in China

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