Incidence of second primary oral cancer tumors: a retrospective study

Sassi, Laurindo Moacir; Cervantes, Onivaldo; Schussel, Juliana Lucena; Stramandinoli, Roberta Targa; Guebur, M.I.; Ramos, Gyl Henrique Albrecht

doi:10.1590/s1980-65232010000400008

Cited by 3 publications

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References 17 publications

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“…The average interval between diagnosis of first primary tumour and SPN was 65 months. 14 Rajani et al in their study on a group of Indian people showed the most common subsites of oral cancer leading to SPN were lower gingivobuccal sulcus followed by palate, tongue and buccal mucosa. 15 Hoarseness of voice is a usual presenting feature of early stage glottic carcinoma while dysphagia and aspiration present late in the course.…”

Section: Discussionmentioning

confidence: 98%

Synchronous Buccal Carcinoma and Laryngeal Carcinoma- A Rare Presentation

Sen¹,

Ghosh²,

Guha

2020

BJOHNS

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Introduction Second primary malignancy as squamous cell carcinoma of larynx is rare after squamous cell carcinoma of buccal mucosa. Case Report A 47 year old male patient presented with a painless, progressive ulcer of left buccal mucosa near the angle of mouth for the last 3 months who also developed alteration in the quality of voice and respiratory distress 2 months later. On biopsy buccal lesion came out to be moderately differentiated squamous cell carcinoma. Direct laryngoscopy revealed a glottic growth and guided biopsy from the lesion revealed well differentiated keratinising squamous cell carcinoma which was managed successfully by total laryngectomy and buccal carcinoma by wide local excision followed by primary closure and supraomohyoid neck dissection in the same sitting. Discussion Having both index primary tumour and second primary tumour in head and neck region is a rare occurrence more so glottic carcinoma occurring synchronously with buccal carcinomas. Surgery is the mainstay of treatment in both the conditions.

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Section: Discussionmentioning

confidence: 98%

Synchronous Buccal Carcinoma and Laryngeal Carcinoma- A Rare Presentation

Sen¹,

Ghosh²,

Guha

2020

BJOHNS

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Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol

et al. 2012

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Tobacco and alcohol are the main extrinsic etiological factors for the genesis of oral squamous cell carcinoma (SCC), but it is still not clear if the presence of these factors interfere with clinical, pathologic and molecular characteristics or with the prognosis of the disease. In the present study, these characteristics were reviewed, establishing comparisons between the lesions of patients exposed and not exposed to tobacco and alcohol. We observed that oral SCC in non smokers and non alcohol drinkers occur mainly in female patients, under 50 or over 70 years old. The lesions tend to be less aggressive in this group of patients and have a better prognosis. The molecular characteristics of these malignant tumors also appear to be influenced by the presence of these habits, once mutations of p53 have been associated with tobacco and alcohol use. The understanding of the differences between the neoplasms of these two groups of patients can contribute to the management of this cancer, which could lead to advances in the determination of more appropriate therapeutic measures. Kew words: Oral cancer; risk factors; prognosis ResumoO tabaco e o álcool são os principais fatores etiológicos extrínsecos associados à gênese do carcinoma bucal de células escamosas (CCE), mas não está claro se estes fatores interferem nas características clínico-patológicas, moleculares ou no prognóstico da doença. No presente estudo, essas características foram revisadas, estabelecendo-se comparações entre as lesões de pacientes usuários ou não de tabaco e álcool. Observou-se que carcinomas bucais de não fumantes e não etilistas ocorrem, preferencialmente, em pacientes do sexo feminino, em faixa etária inferior a 50 ou superior 70 anos. Neste grupo de indivíduos, as lesões tendem a ser menos agressivas e apresentam melhor prognóstico. O tabagismo e o etilismo também parecem influenciar as características moleculares do carcinoma bucal, uma vez que mutações da proteína p53 nas lesões têm sido associadas a esses fatores de risco. A compreensão das diferenças entre os CCE bucais desses dois grupos de pacientes pode contribuir para uma melhor abordagem e avanços no desenvolvimento de medidas terapêuticas mais adequadas frente a esta neoplasia. Oral squamous cell carcinoma

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Informed Consent Status in Observational Studies With Retrospective Design: A Poor Show

Bansal

Gill

Gupta

2017

Asian J Pharm Clin Res

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Objective: Informed consent is very important to protect the rights of patients and is obtained as a vital component of any clinical study. Requirement of patient consent in retrospective research continues to stir controversy even today. Some of directions of regulatory authorities even waive off the consent for retrospective studies, whereas few recommend that at least clearance from the Ethical Review Board may be taken or information to patient may be given or oral consent must be given by patient for usage of the data in any retrospective study. The aim of this study was to analyze the current status of informed consent procedures in observational studies with retrospective design. Methods:This review was intended to find out the current status of procedures involved in informed consent in India and abroad. A total of 100 retrospective studies were searched for this objective from the internet and other literature sources.Results: Data show that in 65% of studies neither informed consent/oral consent nor ethical clearance was taken. Only 1% of studies have been conducted with informed consent as well as ethical clearance. Only 14% of studies were conducted with informed consent and 21% with ethical approval. Conclusion:The study reflects very poor status of informed consent in retrospective studies and noncompliance of ICH guidelines for clinical research in relation to informed consent.

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Incidence of second primary oral cancer tumors: a retrospective study

Cited by 3 publications

References 17 publications

Synchronous Buccal Carcinoma and Laryngeal Carcinoma- A Rare Presentation

Synchronous Buccal Carcinoma and Laryngeal Carcinoma- A Rare Presentation

Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol

Informed Consent Status in Observational Studies With Retrospective Design: A Poor Show

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