Incidence of splayleg pigs in Nebraska litter size selection lines1

Holl, J. W.; Johnson, R. K.

doi:10.2527/2005.83134x

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…†P < 0.10; *P < 0.05. 1991; Rothschild and Bidanel, 1998), but is lower than the estimates recently reported by Ruiz-Flores and Johnson (2001) and Holl and Johnson (2005). Conversely, the heritability estimate obtained for WP is lower than most estimates reported in the literature (Bidanel et al, 1996;Ruiz-Flores and Johnson, 2001).…”

Section: Discussionmentioning

confidence: 67%

Correlated responses for litter traits to six generations of selection for ovulation rate or prenatal survival in French Large White pigs

Rosendo¹,

Druet²,

Gogué³

et al. 2007

Journal of Animal Science

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Effects of selection for reproductive traits were estimated using data from 3 pig lines derived from the same Large White population base. Two lines were selected for 6 generations on high ovulation rate at puberty (OR line) or high prenatal survival corrected for ovulation rate in the first 2 parities (PS line). The third line was an unselected control line. Genetic parameters for age and BW at puberty (AP and WP); number of piglets born alive, weaned, and nurtured (NBA, NW, and NN, respectively); proportions of stillbirth (PSB) and survival from birth to weaning (PSW); litter and average piglet BW at birth (LWB and AWB), at 21 d (LW21 and AW21), and at weaning (LWW and AWW) were estimated using REML methodology. Heritability estimates were 0.38 +/- 0.03, 0.46 +/- 0.03, 0.16 +/- 0.01, 0.08 +/- 0.01, 0.09 +/- 0.01, 0.04 +/- 0.01, 0.04 +/- 0.02, 0.19 +/- 0.02, 0.10 +/- 0.02, 0.10 +/- 0.02, 0.36 +/- 0.02, 0.27 +/- 0.01, and 0.24 +/- 0.01 for AP, WP, NBA, PSB, NW, NN, PSW, LWB, LW21, LWW, AWB, AW21, and AWW, respectively. The measures of litter size showed strong genetic correlations (r(a) >/= 0.95) and had antagonistic relations with PSB (r(a) = -0.59 to -0.75) and average piglet BW (r(a) = -0.19 to -0.46). They also had strong positive genetic correlations with prenatal survival (r(a) = 0.67 to 0.78) and moderate ones with ovulation rate (r(a) = 0.36 to 0.42). Correlations of litter size with PSW were negative at birth but positive at weaning. The OR and PS lines were negatively related to PSW and average piglet BW. Puberty traits had positive genetic correlations with OR and negative ones with PS. Genetic trends were estimated by computing differences between OR or PS and control lines at each generation using least squares and mixed model methodologies. Average genetic trends were computed by regressing line differences on generation number. Significant (P < 0.05) average genetic trends were obtained in OR and PS lines for AP (respectively, 2.1 +/- 0.9 and 3.2 +/- 1.0 d/generation) and WP (respectively, 2.0 +/- 0.5 and 1.8 +/- 0.5 d/generation) and in the PS line for NBA (0.22 +/- 0.10 piglet/generation). Tendencies (P < 0.10) were also observed for LWB (0.21 +/- 0.12 kg/generation) and AWW (-0.25 +/- 0.14 kg/generation) in the PS line. Selection on components of litter size can be used to improve litter size at birth, but result in undesirable trends for preweaning survival.

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Section: Discussionmentioning

confidence: 67%

Correlated responses for litter traits to six generations of selection for ovulation rate or prenatal survival in French Large White pigs

Rosendo¹,

Druet²,

Gogué³

et al. 2007

Journal of Animal Science

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“…Si des anomalies comme la hernie scrotale ou la cryptorchidie sont par essence spécifiques des mâles (ou l'intersexualité spécifique des femelles), certaines études rapportent que le « splay-legs » a une incidence deux fois plus importante chez les mâles que chez les femelles (Holl et Johnson 2005). De même la cyphose (une déformation de la colonne vertébrale) serait plus importante chez les mâles castrés que chez les femelles (Straw et al 2009).…”

Section: C) Le Sexeunclassified

Les anomalies congénitales héréditaires chez le porc

et al. 2020

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Les anomalies congénitales sont définies comme des défauts de structure ou de fonction présents à la naissance. Bien que la fréquence des anomalies congénitales soit relativement faible, leur impact en production porcine est significatif. Elles provoquent le plus souvent un mal-être des animaux et une dépréciation des carcasses à l’abattoir induisant des pertes économiques. Les anomalies congénitales peuvent être de nature diverse, mais les défauts les plus courants rencontrés chez le porcelet sont de type urogénital (les hernies inguinales et scrotales, la cryptorchidie et l’intersexualité). Ces défauts peuvent être dus à des problèmes nutritionnels, aux conditions d’environnement ou à la conduite de l’élevage, mais une part de leur déterminisme est très souvent génétique. Les développements récents des outils de génomique permettent désormais d’entreprendre, à grande échelle, des études d’association afin d’identifier les régions chromosomiques des gènes impliqués. L’identification des mutations causales est devenue une priorité afin de proposer de nouveaux schémas de sélection. L’objectif de cet article est de présenter une synthèse des connaissances génétiques sur les anomalies congénitales les plus fréquentes chez le porc et les stratégies mises en œuvre pour gérer ces défauts en sélection.

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“…Copyright © 2007 S. Karger AG, Basel Congenital splay leg is a hereditary disorder in newborn piglets of unknown etiology. Affected animals have an impaired ability to stand and walk and are at high risk of being crushed by the sow (see Maak et al, 2001;Holl and Johnson, 2005;Ooi et al, 2006). Investigations on the genetic background of the disorder resulted in the identification of differentially expressed sequence tags (Maak et al, 2001) and of suggestive QTL regions on porcine chromosomes (SSC) 5 and 11, respectively (Schwarz, 2002 …”

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confidence: 99%

Exclusion of <i>NFYB </i>as candidate gene for congenital splay leg in piglets and radiation hybrid mapping of further five homologous porcine genes from human chromosome 12 (HSA12)

Boettcher

Paul²,

Bennewitz³

et al. 2007

Cytogenet Genome Res

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Nuclear transcription factor Y, beta (NFYB) was evaluated as candidate gene for congenital splay leg in piglets based on data from differential display and QTL analysis. We mapped NFYB to pig chromosome 5 (SSC5). By assigning further five porcine genes from the corresponding region on human chromosome (HSA) 12q23.3→ q24.11 to SSC5 and 14 we could confine an evolutionary breakpoint from an interval of more than 10 Mb to less than 400 kb. Comparative sequence analysis of the coding region of NFYB in healthy and splay leg piglets revealed no polymorphism. Inter-species conservation of the codons ranges from 87% to 95% between pig, human, cow, dog, rat and mouse, respectively. The expression of NFYB in M. biceps femoris was not different between healthy and splay leg piglets. However, healthy male piglets had a significantly higher expression than females. Our results exclude NFYB as candidate gene for congenital splay leg but provide a basis for selection of further candidates for the disease from SSC5.

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Incidence of splayleg pigs in Nebraska litter size selection lines1

Cited by 7 publications

References 13 publications

Correlated responses for litter traits to six generations of selection for ovulation rate or prenatal survival in French Large White pigs

Correlated responses for litter traits to six generations of selection for ovulation rate or prenatal survival in French Large White pigs

Les anomalies congénitales héréditaires chez le porc

Exclusion of <i>NFYB </i>as candidate gene for congenital splay leg in piglets and radiation hybrid mapping of further five homologous porcine genes from human chromosome 12 (HSA12)

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