Incidence of Transfusion-Related Adverse Reactions per Patient Reflects the Potential Risk of Transfusion Therapy in Japan

Kato, Hidefumi; Uruma, Motoaki; Okuyama, Yoshiki; Fujita, Hiroshi; Handa, Makoto; Tomiyama, Yoshiaki; Shimodaira, Shigetaka; Kurata, Yoshiyuki; Takamoto, Shigeru

doi:10.1309/ajcp6sbpox0uwhek

Cited by 49 publications

(48 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The average age of www.ee.usp.br/reeusp Rev Esc Enferm USP · 2018;52:e03331 participants in this study was 44 years, which is similar to that found in a study carried out in northwest India (9) , with an average age of 44.3 years. This is well below that found among Japanese receptors, whose average age was 56.7 years, with 94% of reactions occurring among people aged over 18 (10) . Among the patients in this study who had transfusion reactions, we observed a slight difference with regard to gender: 50.7% men and 49.3% women.…”

Section: Between May 2002 and December 2016 Hospital Sãocontrasting

confidence: 54%

“…Among severe reactions, 57.1% (12/21) were allergic, followed by TACO at 23.8% (5/21). Among those of greater morbidity were TRALI at 9.5% (2/21) and AHTR at 4.8% (1/21) (8,10,14) . TRALI, which is a severe reaction, is not frequently reported by services and this leads some authors to suggest the occurrence of underreporting as a result of the lack of preparation or knowledge within these services (16,(22)(23) .…”

Section: Between May 2002 and December 2016 Hospital Sãomentioning

confidence: 99%

See 1 more Smart Citation

Hemovigilância: a experiência da notificação de reações transfusionais em Hospital Universitário

Grandi

Grell

Areco

et al. 2018

Rev. esc. enferm. USP

View full text Add to dashboard Cite

Objective:To describe the occurrence of immediate transfusion reactions received by the Risk Management Department of Hospital São Paulo. Method: Cross-sectional and retrospective study which analyzed the notification sheets of transfusion reactions that occurred between May 2002 and December 2016 and were included in the Hemovigilance National System. Results: One thousand five hundred and forty-eight transfusion reaction notification sheets were analyzed, all of which concerned immediate reactions associated with packed red blood cells (72.5%). The most frequently reported reaction was febrile non-hemolytic transfusion reaction, and among severe and moderate cases, allergic reaction was the most common. The most frequently reported signs and symptoms were hyperthermia, sudoresis, chills, and skin lesions. No differences were observed regarding gender and age, and 90.7% of reactions occurred in patients with Rh+ factor. Conclusion: This study allowed for a better assessment and understanding of transfusion reactions, which will help to improve the quality of blood circulation and provide greater safety of patients undergoing transfusion therapy.

show abstract

Section: Between May 2002 and December 2016 Hospital Sãocontrasting

confidence: 54%

Section: Between May 2002 and December 2016 Hospital Sãomentioning

confidence: 99%

Hemovigilância: a experiência da notificação de reações transfusionais em Hospital Universitário

Grandi

Grell

Areco

et al. 2018

Rev. esc. enferm. USP

View full text Add to dashboard Cite

show abstract

“…Other studies also have reported a similar incidence of these non-infectious transfusion reactions [20,21]. Therefore, while commonest type of reactions reported in our study were similar to that reported earlier from India, overall incidence was much higher in our study.…”

Section: Discussionsupporting

confidence: 91%

“…Therefore, reaction per patient rather than the overall incidence seems to be a better predictor of the risk [21] and thus should be reported in all such studies. As our hospital was a new facility, software implementation was initially patchy and patient demographics could not be captured seamlessly.…”

Section: Discussionmentioning

confidence: 99%

Active Hemovigilance Significantly Improves Reporting of Acute Non-infectious Adverse Reactions to Blood Transfusion

Agnihotri

2015

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

One of the key purposes of a hemovigilance program is to improve reporting of transfusion related adverse events and subsequent data-driven improvement in blood transfusion (BT) practices. We conducted a study over 3 years to assess the impact of healthcare worker training and an active feedback programme on reporting of adverse reactions to BTs. All hospitalized patients who required a BT were included in the study. Healthcare workers involved in BT to patients were sensitized and trained in adverse reaction reporting by conducting training sessions and meetings. All the transfused patients were 'actively' monitored for any acute adverse reaction by using a uniquely coded blood issue form. A total of 18,914 blood components transfused to 5785 different patients resulted in 61 adverse reaction episodes. This incidence of 0.32 % in our study was found to be significantly higher (p \ 0.005) than that reported from the same region in the past. Red blood cell units were the most frequently transfused component and thus most commonly involved in an adverse reaction (42.6 %), however apheresis platelets had the highest chance of reaction per unit transfused (0.66 %). There was no mortality associated with the BT during the study period. An active surveillance program significantly improves reporting and management of adverse reactions to BTs.

show abstract

“…This pediatric rate was approximately threefold higher than the adult rate of approximately two per 1000 transfusions. Much of the published data describing rate and frequency of transfusion reactions in adults were obtained from countrywide hemovigilance data and, therefore, do not specifically segregate pediatric from adult data, although these numbers are often referenced as “adult” data since the majority of hospitalized patients are adults . These data reference a range of approximately 2.5 to 3.3 in 1000 .…”

Section: Discussionmentioning

confidence: 99%

Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products

Oakley¹,

Woods

Arnold³

et al. 2014

Transfusion

117

112

View full text Add to dashboard Cite

To our knowledge this is the first study to provide detailed comparisons of acute transfusion reactions to all blood products between pediatric and adult populations at a single institution and supported by a single transfusion service and culture. Collectively these data provide insight into pediatric transfusion reactions and demonstrate a general increase in the incidence of transfusion reactions within the pediatric compared to adult population.

show abstract

Incidence of Transfusion-Related Adverse Reactions per Patient Reflects the Potential Risk of Transfusion Therapy in Japan

Abstract: The incidence of ARs per transfused patient may reflect better the potential risk of transfusion with blood components, taking into account the characteristics of the transfused patient.

Cited by 49 publications

References 11 publications

Hemovigilância: a experiência da notificação de reações transfusionais em Hospital Universitário

Hemovigilância: a experiência da notificação de reações transfusionais em Hospital Universitário

Active Hemovigilance Significantly Improves Reporting of Acute Non-infectious Adverse Reactions to Blood Transfusion

Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products

Contact Info

Product

Resources

About