Incidence of Type 1 Diabetes in Children Aged Below 18 Years During 2013-2015 in Northwest Turkey

Abstract

Objective:To assess the incidence of type 1 diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015.Methods:All newly diagnosed T1DM cases were recorded prospectively during 2013-2015. Total, as well as gender and age group specific (0-4, 5-9, 10-14 and 15-17 age) mean incidences per 100,000 per year were calculated.Results:There were 1,773 patients diagnosed during 2013-2015 (588 cases in 2013, 592 cases in 2014, 593 cases in 2015). Of these, 862 (48.6%) were girls and 911 (51.4%) were boys. The mean age at diagnosis was 9.2±4.2 years and it was not significantly different between girls (9.0±4.1 years) and boys (9.4±4.4 years) (p=0.052). The crude mean incidence was 8.99/100.000 confidence interval (CI) (95% CI: 8.58-9.42). Although mean incidence was similar between boys [8.98/100.000 (CI: 8.40 to 9.58)] and girls [9.01/100.000 (CI: 8.42 to 9.63)], there was male predominance in all groups except for 5-9 year age group. The standardized mean incidence was 9.02/100.000 according to the World Health Organization standard population. The mean incidence for the 0-4, 5-9, 10-14 and 15-17 age groups was 6.13, 11.68, 11.7 and 5.04/100.000 respectively. The incidence of T1DM was similar over the course of three years (p=0.95). A significant increase in the proportion of cases diagnosed was observed in the autumn-winter seasons.Conclusion:The northwest region of Turkey experienced an intermediate incidence of T1DM over the period of the study.

Trend of type 1 diabetes incidence in children between 2009 and 2019 in Elazig, Turkey

“…Over 1998 to 2014 T1D incidence doubled (1.5 to 3.1/100 000 population aged <15 years, 5.6% annualized increase, P = .001) in Uzbekistan . Turkey was accepted in group of countries with an intermediate incidence rate incidence rate of T1D among children which is based on limited data . With this study we have reported highest regional incidence rate of T1D until now in Turkey.…”

“…Incidence of T1D has been suggested to have increased over the past few decades . However, scant data on the incidence of T1D in childhood is available from Turkey . The only reported nationwide incidence rate of T1D among children aged <15 years was 11.3 per 100 000 person‐years in 2013 .…”

“…The only reported nationwide incidence rate of T1D among children aged <15 years was 11.3 per 100 000 person‐years in 2013 . Additionally, two regional study reported incidences of 7.2 and 9.8 per 100 000 children aged <15 years in the southeast and northwest region of Turkey, respectively . These studies were limited by short evaluation periods and two of three are regional reports.…”

Epidemiological Characteristics of Diabetic Children in the Province of Adıyaman

“…Türkiye'de Yeşilkaya ve arkadaşları tarafından yapılan T1DM insidans ve prevelans çalışmasında yeni tanı diyabetli çocukların %40,6'sı10-14 yaş, %25,7'si 5-9 yaş, %18.9'u 15-18 yaş ve %14.8'i 0-4 yaş arası olarak tespit edilmiştir (20).Demiral ve arkadaşları tarafından Eskişehir ilinde yapılan çalışmada T1DM sıklığının yaşla birlikte arttığı ve en sık 11-17 yaş grubunda tespit edildiği bildirilmiştir (21). Türkiye'nin kuzeybatı bölgesinde yapılan diğer bir çalışmada iseT1DM'nin 5-9 yaş ile 10-14 yaşları arasında yoğunluk gösterdiği saptanmıştır (22). Sosyoekonomik durumu, coğrafi bölge ve iklim yapısının farklı olduğu bölgemizde yaptığımız çalışmada ise T1DM'ın 10-14 yaşlar arasında zirve yaptığı, bunu 5-9 yaş grubunun izlediği görülmektedir.…”

The Incidence and Demographic Distribution of Type 1 Diabetes Mellitus in Children Aged 16 or Younger Between 2000 and 2016 in Cyprus

“…Type 1 diabetes (T1D) arises from the autoimmune destruction of pancreatic β-cells leading to a life-long dependence on exogenous insulin (1). The disease most commonly presents in children and adolescents (2). T1D also been reported.…”