Incidence of viral respiratory pathogens causing exacerbations in adult cystic fibrosis patients

Hoek, Rogier A.S.; Paats, Marthe S.; Pas, Suzan D.; Bakker, Marleen; Hoogsteden, Henk C.; Boucher, Charles A.; Eerden, Menno M. van der

doi:10.3109/00365548.2012.708942

Cited by 81 publications

(66 citation statements)

References 18 publications

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“…Recently, viral respiratory infections in CF were given more and more attention [31], [32]. In pediatric and adult CF patients the risk of pulmonary exacerbations as well as length and frequency of hospitalizations were found to be increased by viral respiratory infections.…”

Section: Introductionmentioning

confidence: 99%

Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Renk

Regamey²,

Hartl

2014

PLoS ONE

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BackgroundTo systematically assess the literature published on the clinical impact of Influenza A(H1N1)pdm09 on cystic fibrosis (CF) patients.MethodsAn online search in PUBMED database was conducted. Original articles on CF patients with Influenza A(H1N1)pdm09 infection were included. We analyzed incidence, symptoms, clinical course and treatment.ResultsFour surveys with a total of 202 CF patients infected by Influenza A(H1N1)pdm09 were included. The meta-analysis showed that hospitalisation rates were higher in CF patients compared to the general population. While general disease symptoms were comparable, the clinical course was more severe and case fatality rate (CFR) was higher in CF patients compared to asthmatics and the general population.ConclusionsEvidence so far suggests that CF patients infected with Influenza A(H1N1)pdm09 show increased morbidity and a higher CFR compared to patients with other chronic respiratory diseases and healthy controls. Particularly, CF patients with advanced stage disease seem to be more susceptible to severe lung disease. Accordingly, early antiviral and antibiotic treatment strategies are essential in CF patients. Preventive measures, including vaccination as well as hygiene measures during the influenza season, should be reinforced and improved in CF patients.

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Section: Introductionmentioning

confidence: 99%

Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Renk

Regamey²,

Hartl

2014

PLoS ONE

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“…In adults and children with CF, viral infections can trigger pulmonary exacerbations, [269][270][271][272] particularly influenza virus 271,273 and rhinovirus. 269,270 Exacerbations in which a virus is identified are associated with worse clinical severity compared with viral exacerbations.…”

Section: Iiib3 Respiratory Virusesmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

352

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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“…Only a few Cap sequences of picobirnaviruses are available; these sequences show <25% amino acid identity to each other, and a clear genogroup division cannot be distinguished (Figure 1, panel C). A picobirnavirus VS6600008-specific real time PCR was performed on the total sample set with primers VS791 (5′-CGATGGATCTTTATGTTCCCG-3′), VS792 (5′-GTAGTTGAAATGTTGATCCATTT-3′), and VS793 (5′-CAAACTTTCCAGCAACCGCTT-3′) labeled with 6-carboxy-fluorescein and 6-carboxy-tetramethyl-rhodamine as described ( 10 ). Only the sample from patient VS6600008 had a positive result (cycle threshold 25.1).…”

Section: The Studymentioning

confidence: 99%