Incidence, Predictors, Costs, and Outcome of Renal Cell Carcinoma After Kidney Transplantation: USRDS Experience

Abstract

RCC was diagnosed disproportionately early in patients with pretransplant renal cysts and was associated with a worse prognosis and increased costs.

Case Report: Renal Cell Carcinoma of First Kidney Allograft in Transplanted Recipient for Second Time

“…Other factors like genetic factors, chronic viral infections, cigarette smoking, radiation, longer graft survival, older donor as well as recipient, African Americans and introduction of more potent immunosuppression were all encountered too [6,7]. The occurrence of graft rejection in the first post-transplant year can increase the incidence of secondary neoplasm; possibly due to escalation of immunosuppressive level required to treat the rejection episode [4,6].…”

Renal Cell Carcinoma and Mucinous Adenocarcinoma of Ureter after Renal Transplantation with Neoplasm of Urethra in Follow up

“…8 At the end of the third postoperative year, there is a 15-fold higher risk of disease in transplant recipients compared to the general population in the United States (3.16 per 1000 person-years), and 39% higher than those on the waiting list for transplantation. 5 Many patients are transplanted with unknown neoplasms. In the study by Denton et al, 1 the histopathological evaluations of one of the primitive kidneys in a series of 260 patients identified 11 (4.2%) cases of RCC; all of these patients were asymptomatic and the tumors were not identified by imaging before exeresis.…”

Complications of Kidney Transplantation: Effects of Over-Immunosuppression

“…Patients with pre-transplant cystic lesions are more likely to develop RCC by three years after transplant compared to those without (2.3% vs. 0.7%, respectively) [115]. Risk factors for developing RCC after transplant have included pre-transplant cystic disease/lesions, male gender, African-American race, older recipients (> 65 years at transplant), longer time on dialysis prior to transplant, older donor age (> 55 years), and treatment of acute rejection within 1 year of transplant [114,115].…”

“…Renal cell carcinoma (RCC) of the native kidney(s) is diagnosed in 0.3% to 4.8% of kidney transplant recipients [114,115], and in the transplant kidney in approximately 0.2% [116].…”

“…Risk factors for developing RCC after transplant have included pre-transplant cystic disease/lesions, male gender, African-American race, older recipients (> 65 years at transplant), longer time on dialysis prior to transplant, older donor age (> 55 years), and treatment of acute rejection within 1 year of transplant [114,115]. Most cases of RCC have papillary or clear cell histology, and RCC in one kidney is associated with RCC in the contralateral native kidney.…”