Incidence Rates of Ulcerative Colitis and Crohn's Disease in Fifteen Areas of the United States

Garland, Cedric F.; Lilienfeld, Abraham M.; Mendeloff, Albert I.; Markowitz, Jan A.; Terrell, Katherine B.; Garland, Frank C.

doi:10.1016/s0016-5085(81)80021-2

Cited by 203 publications

(37 citation statements)

References 15 publications

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“…Such a distribution was noted in four studies. 18,20,22,24 However, a`unimodal' distribution, with a peak incidence in the second or third decades, followed by a gradually diminishing incidence thereafter, was also seen in four studies. 14,16,19,21 In a single study, the peak incidence was seen after 50 years.…”

Section: Incidence Of Crohn's Disease In North Americamentioning

confidence: 84%

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The epidemiology and natural history of Crohn’s disease in population‐based patient cohorts from North America: a systematic review

Loftus

Schoenfeld

Sandborn

2002

Aliment Pharmacol Ther

418

246

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Aim: To quantify, through systematic review, the epidemiology and natural history of Crohn’s disease in North America. Methods: The selected articles contained: (i) population‐based samples of patients followed from the time of diagnosis; and (ii) objective diagnostic criteria for disease. Studies on the natural history of Crohn’s disease also contained sufficient follow‐up. Data collection and analysis: For prevalence studies, data on the incidence, prevalence, gender and age at diagnosis were extracted. For natural history studies, data on the disease activity, use of medications and surgery were extracted. Main results: The prevalence of Crohn’s disease in North America ranges from 26.0 to 198.5 cases per 100 000 persons. The incidence rates range from 3.1 to 14.6 cases per 100 000 person‐years. Most patients have a chronic intermittent disease course, while 13% have an unremitting disease course and 10% have a prolonged remission. Less than half require corticosteroids at any point. During any given year, approximately 10% are treated with corticosteroids and 30% are treated with 5‐aminosalicylates. Up to 57% of patients require at least one surgical resection. Conclusions: Between 400 000 and 600 000 patients in North America have Crohn’s disease, and the natural history is marked by frequent exacerbations requiring treatment with corticosteroids, 5‐aminosalicylate products and surgery.

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Section: Incidence Of Crohn's Disease In North Americamentioning

confidence: 84%

“…It was under 50% in only one study, performed three decades ago. 24 Information on the age at diagnosis of Crohn's disease was explicitly presented in only two studies. 14,20 The mean age at diagnosis could be estimated from tables showing the age distribution in ®ve additional cohorts.…”

Section: Incidence Of Crohn's Disease In North Americamentioning

confidence: 99%

The epidemiology and natural history of Crohn’s disease in population‐based patient cohorts from North America: a systematic review

Loftus

Schoenfeld

Sandborn

2002

Aliment Pharmacol Ther

418

246

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“…The choice of diagnostic criteria is crucial when different studies of inflammatory bowel disease are compared. Garland et al divided ulcerative colitis and Crohn's disease into definite, probable and possible cases (22). Several studies considered definite and probable cases together (8,10,13,14).…”

Section: Discussionmentioning

confidence: 99%

Incidence and prevalence of inflammatory bowel disease in children in South-Western Sweden

Hildebrand¹,

Brydolf²,

Holmquist

et al. 2008

Acta Paediatrica

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Hildebrand H, Brydolf M, Holmquist L, Krantz I, Kristiansson B. Incidence and prevalence of inflammatory bowel disease in children in South‐Western Sweden Acta PEdiatr 1994;83:640–5. Stockholm. ISSN 0803–5253 The incidence and prevalence of inflammatory bowel disease were estimated in all children less than 16 years of age living in the city of Göteborg and in three counties in South‐Western Sweden, from 1983 to 1987. One hundred and thirty‐two patients were classified according to set criteria into one of four diagnostic categories: ulcerative colitis, Crohn's disease, probable Crohn's disease and indeterminate colitis. The crude incidence of inflammatory bowel disease was 5.3 per 100 000 children per year and the prevalence 21.5 per 100000 children. This study lends support to the hypothesis that Crohn's disease has increased among Swedish children. Crohn's disease now appears to be at least as common as ulcerative colitis. Thirty‐five of 55 patients first classified as indeterminate colitis or probable Crohn's disease later fulfilled the criteria of ulcerative colitis or Crohn's disease during a mean follow‐up period of 4.6 years. This study emphasizes the importance, in epidemiological studies of inflammatory bowel disease, of inciuding those cases where a definite diagnosis of ulcerative colitis or Crohn's disease cannot be established initially and of re‐evaluating the initial diagnosis regularly.

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“…The combined practice population was 163 383. Case definition was based on that described by Garland et al, 9 and has been discussed in detail previously. 8 Briefly, a specialist diagnosis supported by confirmatory evidence from histological, endoscopic, radiological or operative findings was essential for inclusion.…”

Section: Methodsmentioning

confidence: 99%

Quality of life in patients with established inflammatory bowel disease: a UK general practice survey

Rubin

Hungin

Chinn

et al. 2004

Aliment Pharmacol Ther

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SUMMARYBackground: The current understanding of quality of life impairment in inflammatory bowel disease has largely been derived from selected populations and may not reflect the experience of patients in the community, where fewer than half are likely to be under specialist care. Aim: To describe the health-related quality of life in a community-based sample of patients with established inflammatory bowel disease and explore its association with the type and extent of disease, gender, age, material deprivation and other factors. Methods: Adults with established inflammatory bowel disease were identified systematically from the records of 23 family practices in north-east England. The healthrelated quality of life was assessed by self-completion of the UK Inflammatory Bowel Disease Questionnaire.

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Incidence Rates of Ulcerative Colitis and Crohn's Disease in Fifteen Areas of the United States

Cited by 203 publications

References 15 publications

The epidemiology and natural history of Crohn’s disease in population‐based patient cohorts from North America: a systematic review

The epidemiology and natural history of Crohn’s disease in population‐based patient cohorts from North America: a systematic review

Incidence and prevalence of inflammatory bowel disease in children in South-Western Sweden

Quality of life in patients with established inflammatory bowel disease: a UK general practice survey

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