Incidence trends of breast cancer in Saudi Arabia: A joinpoint regression analysis (2004–2016)

Albeshan, Salman M.; Alashban, Yazeed

doi:10.1016/j.jksus.2021.101578

Cited by 30 publications

(26 citation statements)

References 13 publications

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“…Even though the etiology for breast cancer has not been completely understood, certain risk factors, including older age, genetic predisposition, family history, early menarche, late menopause, exogenous hormone usage, and obesity, play a significant role in the breast cancer development [ 4 , 5 ]. In the Kingdom of Saudi Arabia (KSA), breast cancer ranks as the number one reported cancer (14.2%), and cancer-related deaths among women have an increasing annual incidence of 3.01% and a mortality of 0.93% [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Female Healthcare Workers’ Knowledge, Attitude towards Breast Cancer, and Perceived Barriers towards Mammogram Screening: A Multicenter Study in North Saudi Arabia

et al. 2022

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Breast cancer is the most commonly diagnosed cancer among women in the Kingdom of Saudi Arabia and other Middle East countries. This analytical cross-sectional study assessed knowledge, attitude towards breast cancer, and barriers to mammogram screening among 414 randomly selected female healthcare workers from multiple healthcare facilities in northern Saudi Arabia. Of the studied population, 48.6% had low knowledge, and 16.1% had a low attitude towards breast cancer risk factors and symptoms. The common barriers to mammogram screening were fear to discover cancer (57.2%) and apprehension regarding radiation exposure (57%). Logistic regression analysis found that lack of awareness regarding mammogram was significantly associated with age (p = 0.030) and healthcare workers category (ref: physicians: p = 0.016). In addition, we found a significant negative correlation between knowledge and barrier scores (Spearman’s rho: −0.315, p < 0.001). It is recommended to develop target-oriented educational programs for the healthcare workers, which would empower them to educate the community regarding the risk factors and the importance of mammogram screening. Furthermore, a prospective study is warranted in other regions of the Kingdom of Saudi Arabia to understand the region-specific training needs for the healthcare workers.

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Section: Introductionmentioning

confidence: 99%

Female Healthcare Workers’ Knowledge, Attitude towards Breast Cancer, and Perceived Barriers towards Mammogram Screening: A Multicenter Study in North Saudi Arabia

et al. 2022

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“…BC in Saudi Arabia is increasing as shown in one report investigating the trend of BC in the country [7], it also showed the increase in the incidence by 17% between 2004 and 2016 [7]. Although Saudi Arabia provides a free and high-quality breast care services, the incidence of BC and its mortality and morbidity are still increasing.…”

Section: Introductionmentioning

confidence: 99%

Women’s Awareness and Beliefs of Breast Cancer at Al-Baha, Saudi Arabia

Hakami¹

2022

SJMS

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Background: Women’s awareness and beliefs about breast cancer in Saudi Arabia were not fully investigated. The aim of this descriptive study was to assess women’s awareness and beliefs toward breast cancer in Al-Baha, Saudi Arabia. Methods: This is a descriptive cross-sectional study; it was conducted among women attending the Women and Child Care Center at Alawi Royal Mall in Alaqiq for mammogram screening of breast cancer. A convenient sampling technique was used; it included women who attended the center in the period from September 2021 to December 2021, and who agreed to participate. The data were collected using a questionnaire consisting of questions on awareness and beliefs toward breast cancer. The data were analyzed using SPSS software. Results: The current study showed that the level of awareness in women was high toward breast cancer general information (42.9%), the meaning of malignancy (54.3%), and ways for detecting breast cancer (42.9%), it was also shown that they had fair awareness on myths related to breast cancer (45.7%), and signs and symptoms of breast cancer (51.4%). The study also showed that the women have a high level of beliefs toward breast cancer health services (48.6%), the ability of breast cancer to be prevalent in some families (45.7%), the ways of breast cancer self-detection (34.3%), and mammogram role in early detection of breast cancer (34.3%). It was found that the occupation of women and women’s level of education significantly improved the awareness in women. It was shown that the occupation of women and their level of education were significantly related to the level of beliefs toward breast cancer (21.4%) compared to 16.7% for women working in the private sectors. Conclusion: Women in Al-Baha have a high level of awareness and beliefs about breast cancer. The occupation of women and women’s level of education are associated with a high level of awareness and beliefs toward breast cancer.

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“…Breast cancer (BC) is recognized as one of the most common types of cancer worldwide [ 1 ]. In Saudi Arabia (2018), the age-standardized rates (ASR) of BC incidence and mortality were 27.3 and 7.5 per 100,000 Saudi women, respectively (IARC, 2020) [ 2 ]. Etiologically, BC can be developed by several promoting factors categorized as genetic or non-genetic.…”

Section: Introductionmentioning

confidence: 99%

E. coli Secretome Metabolically Modulates MDA-MB-231 Breast Cancer Cells’ Energy Metabolism

AlMalki

Sebaa

Al-Ansari

et al. 2023

IJMS

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Breast cancer (BC) is commonly diagnosed in women. BC cells are associated with altered metabolism, which is essential to support their energetic requirements, cellular proliferation, and continuous survival. The altered metabolism of BC cells is a result of the genetic abnormalities of BC cells. Risk factors can also enhance it, including age, lifestyle, hormone disturbances, etc. Other unknown BC-promoting risk factors are under scientific investigation. One of these investigated factors is the microbiome. However, whether the breast microbiome found in the BC tissue microenvironment can impact BC cells has not been studied. We hypothesized that E. coli, part of a normal breast microbiome with more presence in BC tissue, secretes metabolic molecules that could alter BC cells’ metabolism to maintain their survival. Thus, we directly examined the impact of the E. coli secretome on the metabolism of BC cells in vitro. MDA-MB-231 cells, an in vitro model of aggressive triple-negative BC cells, were treated with the E. coli secretome at different time points, followed by untargeted metabolomics analyses via liquid chromatography–mass spectrometry to identify metabolic alterations in the treated BC cell lines. MDA-MB-231 cells that were not treated were used as controls. Moreover, metabolomic analyses were performed on the E. coli secretome to profile the most significant bacterial metabolites affecting the metabolism of the treated BC cell lines. The metabolomics results revealed about 15 metabolites that potentially have indirect roles in cancer metabolism that were secreted from E. coli in the culture media of MDA-MB-231 cells. The cells treated with the E. coli secretome showed 105 dysregulated cellular metabolites compared to controls. The dysregulated cellular metabolites were involved in the metabolism of fructose and mannose, sphingolipids, amino acids, fatty acids, amino sugar, nucleotide sugar, and pyrimidine, which are vital pathways required for the pathogenesis of BC. Our findings are the first to show that the E. coli secretome modulates the BC cells’ energy metabolism, highlighting insights into the possibility of altered metabolic events in BC tissue in the actual BC tissue microenvironment that are potentially induced by the local bacteria. Our study provides metabolic data that could be as a basis for future studies searching for the underlying mechanisms mediated by bacteria and their secretome to alter the metabolism of BC cells.

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Incidence trends of breast cancer in Saudi Arabia: A joinpoint regression analysis (2004–2016)

Cited by 30 publications

References 13 publications

Female Healthcare Workers’ Knowledge, Attitude towards Breast Cancer, and Perceived Barriers towards Mammogram Screening: A Multicenter Study in North Saudi Arabia

Female Healthcare Workers’ Knowledge, Attitude towards Breast Cancer, and Perceived Barriers towards Mammogram Screening: A Multicenter Study in North Saudi Arabia

Women’s Awareness and Beliefs of Breast Cancer at Al-Baha, Saudi Arabia

E. coli Secretome Metabolically Modulates MDA-MB-231 Breast Cancer Cells’ Energy Metabolism

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