Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination

Zhang, Di; Huang, Qi‐Fang; Li, Yan; Wang, Ji‐Guang

doi:10.1097/mbp.0000000000000554

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Например, хорошо изучен гипокальциурический эффект гидрохлортиазида, который находит клинической применение при метафилактике кальций-оксалатного нефролитиаза и особенно идиопатической гиперкальциурии [1][2][3][4]. Однако гидрохлортиазид и близкий к нему по своим фармакологическим свойствам индапамид склонны снижать скорость клубочковой фильтрации (СКФ) и вызывать гиперурикемию [5][6][7][8][9].…”

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Тhe impact of therapy for chronic heart failure on the lithogenic properties of urine.

Royuk,

Yarovoy,

Grishina

et al. 2023

ECU

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Introduction. In cardiology practice, a considerable number of drugs, having evident metabolic effects, are used, including those that impact on the process of stone formation. The Research Aim. To study the effects of cardiotropic drugs that can affect the likelihood of recurrence of nephrolithiasis. Materials and Methods. The retrospective study was performed on 49 patients suffering from recurrent urate nephrolithiasis and drug-compensated chronic heart failure, who were treated in branch No. N.N. Burdenko” MO in 2018-2022. Two groups of patients were examined, according to the scheme of cardiotropic therapy: group I - losartan, bisoprolol, atorvastatin, clopidogrel, spironolactone, dapagliflozin (n=25); Group II - enalapril, bisoprolol, atorvastatin, acetylsalicylic acid, spironolactone (n=24). Duration of observation is 3 months. Results. When using the scheme based on losartan and dapagliflozin (Group I), a significant decrease in the serum concentration of uric acid and a simultaneous increase in its renal excretion against the background of increased diuresis and a decrease in urine acidity were revealed compared with patients who received the scheme based on enalapril (II group). There were no significant differences between the groups in terms of the risk of decompensation of chronic heart failure, recurrence of stone formation and the frequency of episodes of urinary tract infection. Conclusion. Сardiotropic therapy has a significant effect on the properties of urine in patients with nephrolithiasis. None of the approaches studied demonstrated either overwhelming advantages or disqualifying disadvantages. Both of them have the right to exist. Despite the uricosuric effect, the use of dapagliflozin for the treatment of chronic heart failure in patients with urate nephrolithiasis was not accompanied by an increase in the frequency of recurrence of stone formation.

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Тhe impact of therapy for chronic heart failure on the lithogenic properties of urine.

Royuk,

Yarovoy,

Grishina

et al. 2023

ECU

View full text Add to dashboard Cite

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Seasonal variation in the effect of antihypertensive treatment with the irbesartan/hydrochlorothiazide combination

Huang

et al. 2022

Hypertens Res

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Alcohol Consumption and Antihypertensive Treatment Effect in Male Patients With Hypertension

Ye,

Wang,

Wang

et al. 2023

American Journal of Hypertension

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BACKGROUND Alcohol consumption is a proven risk factor of hypertension. In the present analysis, we investigated the use of antihypertensive medications and blood pressure control in male alcohol drinkers and non-drinkers with hypertension (systolic/diastolic blood pressure 160-199/100-119 mm Hg). METHODS The study participants were patients enrolled in a 12-week therapeutic study and treated with the irbesartan/hydrochlorothiazide combination 150/12.5 mg once daily, with the possible up-titration to 300/12.5 mg/day and 300/25 mg/day at 4 and 8 weeks of follow-up, respectively, for blood pressure control of <140/90 mmHg or <130/80 mmHg in patients with diabetes mellitus. Alcohol consumption was classified as non-drinkers and drinkers. RESULTS The 68 alcohol drinkers and 168 non-drinkers had similar systolic/diastolic blood pressure at baseline (160.8±12.1/99.8±8.6 vs. 161.8±11.0/99.2±8.6, P≥0.55) and other characteristics except for current smoking (80.9% vs. 47.6%, P<0.0001). In patients who completed the 12-week follow-up (n=215), the use of higher dosages of antihypertensive drugs was similar at 4 weeks of follow-up in drinkers and non-drinkers (10.6% vs. 12.4%, P=0.70), but increased to a significantly higher proportion in drinkers than non-drinkers at 12 weeks of follow-up (54.7% vs. 36.6%, P=0.01). The control rate of hypertension tended to be lower in alcohol drinkers, compared with non-drinkers, at 4 weeks of follow-up (45.6% vs. 58.9%, P=0.06), but became similar at 12 weeks of follow-up (51.5% vs. 54.8%, P=0.65). CONCLUSION Alcohol drinkers compared with non-drinkers required a higher dosage of antihypertensive drug treatment to achieve similar blood pressure control.

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Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination

Cited by 3 publications

References 31 publications

Тhe impact of therapy for chronic heart failure on the lithogenic properties of urine.

Тhe impact of therapy for chronic heart failure on the lithogenic properties of urine.

Seasonal variation in the effect of antihypertensive treatment with the irbesartan/hydrochlorothiazide combination

Alcohol Consumption and Antihypertensive Treatment Effect in Male Patients With Hypertension

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