Incidental Finding of Pulmonary Embolism at Workup Before SIRT

Kramer, Stine Jentoft; Amanavicius, Nerijus; Staanum, Peter; Villadsen, Gerda Elisabeth; Arveschoug, Anne Kirstine

doi:10.1097/rlu.0000000000003883

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Labelled albumin systems have great potential in the diagnosis of various diseases. Particles labelled with a γemitting radionuclide are used to evaluate perfusion in the diagnosis of pulmonary embolism [57][58][59] and β-emitting microspheres are used to evaluate lung shunt fraction in the treatment planning of liver tumours [60][61][62]. Developing a blood-pool agent is also possible to evaluate cardiac functions under psychological and pathological conditions [63].…”

Section: Introductionmentioning

confidence: 99%

Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

Bozoglu

Arvas

Varlı³

et al. 2023

Nanotechnology

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Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated with their toxicity such as size, surface modification, solubility, concentration and immunogenicity. Further research needs to be done to address toxicity-related concerns and to increase its effectiveness in various applications. Herein, colloidally stable nanoparticles were prepared by coating magnetic iron oxide nanoparticles (MIONPs) with protocatechuic acid (PCA) which served as a stabilizer and a linkage for a further functional layer. A new perfusion agent with magnetic imaging capability was produced by the adsorption of biocompatible passivating agent macro-aggregated albumin (MAA) on the PCA-coated MIONPs. PCA-coated MIONPs were investigated using infrared spectroscopy, thermogravimetric analysis and dynamic light scattering while adsorption of MAA was analysed by transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR) and x-ray diffraction (XRD) methods. Magnetic measurements of samples indicated that all samples showed superparamagnetic behaviour. Cytotoxicity results revealed that the adsorption of MAA onto PCA-coated MIONPs provided an advantage by diminishing their toxicity against the L929 mouse fibroblast cell line compared to bare Fe3O4.

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Section: Introductionmentioning

confidence: 99%

Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

Bozoglu

Arvas

Varlı³

et al. 2023

Nanotechnology

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“…Hepatocellular carcinoma (HCC) is associated with an increased risk of thrombosis, including venous thromboembolism (VTE), 1 acute cerebral infarction (ACI), 2 acute coronary syndrome (ACS) 3 and disseminated intravascular coagulation. 4 VTE includes pulmonary embolism, 5 deep vein thrombosis (DVT), 6 and portal vein thrombosis (PVT) which is the most frequent site of thrombosis, with a reported incidence of 20%-40%. 7 Both local and systemic factors can foster the development of site-specific thrombosis, particularly PVT.…”

Section: Introductionmentioning

confidence: 99%

Detection of a Prethrombotic State in Patients with Hepatocellular Carcinoma, Using a Clot Waveform Analysis

Fukui,

Wada,

Ikeda

et al. 2024

Clin Appl Thromb Hemost

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Background: Although hepatocellular carcinoma (HCC) is frequently associated with thrombosis, it is also associated with liver cirrhosis (LC) which causes hemostatic abnormalities. Therefore, hemostatic abnormalities in patients with HCC were examined using a clot waveform analysis (CWA). Methods: Hemostatic abnormalities in 88 samples from HCC patients, 48 samples from LC patients and 153 samples from patients with chronic liver diseases (CH) were examined using a CWA-activated partial thromboplastin time (APTT) and small amount of tissue factor induced FIX activation (sTF/FIXa) assay. Results: There were no significant differences in the peak time on CWA-APTT among HCC, LC, and CH, and the peak heights of CWA-APTT were significantly higher in HCC and CH than in HVs and LC. The peak heights of the CWA-sTF/FIXa were significantly higher in HCC than in LC. The peak times of the CWA-APTT were significantly longer in stages B, C, and D than in stage A or cases of response. In the receiver operating characteristic (ROC) curve, the fibrin formation height (FFH) of the CWA-APTT and CWA-sTF/FIXa showed the highest diagnostic ability for HCC and LC, respectively. Thrombosis was observed in 13 HCC patients, and arterial thrombosis and portal vein thrombosis were frequently associated with HCC without LC and HCC with LC, respectively. In ROC, the peak time×peak height of the first derivative on the CWA-sTF/FIXa showed the highest diagnostic ability for thrombosis. Conclusion: The CWA-APTT and CWA-sTF/FIXa can increase the evaluability of HCC including the association with LC and thrombotic complications.

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Incidental Finding of Pulmonary Embolism at Workup Before SIRT

Cited by 2 publications

References 8 publications

Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

Detection of a Prethrombotic State in Patients with Hepatocellular Carcinoma, Using a Clot Waveform Analysis

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