Incidental Gallbladder Cancer at Cholecystectomy

Pitt, Susan C.; Jin, Linda X.; Hall, Bruce L.; Strasberg, Steven M.; Pitt, Henry A.

doi:10.1097/sla.0000000000000485

Cited by 82 publications

(29 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some investigators suggested iGBC was more likely found in elderly patients, dilated bile duct, and thickened GB wall [ 12 ]. Another retrospective study revealed that advanced age, female sex, Asian or African American ethnicity, an elevated ALP, and converted open cholecystectomy as risk factors [ 10 ]. We found that iGBC patients tend to be older, anemic, and on hypertensive medication compared with benign GB diseases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidental gallbladder cancer after routine cholecystectomy: when should we suspect it preoperatively and what are predictors of patient survival?

et al. 2016

View full text Add to dashboard Cite

PurposeIn about 1% of cases, incidental gallbladder cancers (iGBC) are found after routine cholecystectomy. The aim of this study is to compare clinical features of iGBC with benign GB disease and to evaluate factors affecting recurrence and survival.MethodsBetween January 1998 and March 2014, 4,629 patients received cholecystectomy and 73 iGBC patients (1.6%) were identified. We compared clinical features of 4,556 benign GB disease patients with 73 iGBC patients, and evaluated operative outcomes and prognostic factors in 56 eligible patients.ResultsThe iGBC patients were older and concomitant diseases such as hypertension and anemia were more common than benign ones. And an age of more than 65 years was the only risk factor of iGBC. Adverse prognostic factors affecting patients' survival were age over 65, advanced histology, lymph node metastasis, and lymphovascular invasion on multivariate analysis. Age over 65 years, lymph node involvement, and lymphovascular invasion were identified as unfavorable factors affecting survival in subgroup analysis of extended cholecystectomy with bile duct resection (EC with BDR, n = 22).ConclusionPrior to routine cholecystectomy, incidental GB cancer should be suspected especially in elderly patients. And advanced age, lymph node metastasis, and lymphovascular invasion are important prognostic factors in EC with BDR cohorts.

show abstract

Section: Discussionmentioning

confidence: 99%

“…To date, there have been few reports on the predictive factors of iGBC. A recently published article described old age, female gender, Asian or African American, elevated serum ALP and conversion to open cholecystectomy as risk factors in LC patients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Incidental gallbladder cancer after routine cholecystectomy: when should we suspect it preoperatively and what are predictors of patient survival?

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Incidental GB cancer, that is cancer detected once a cholecystectomy has been performed, usually for gallstone disease has been reported to range from 0.2% [36] to 0.9% [37]. A study by Fuks and colleagues studied 218 patients with incidental GB cancer: 67 males and 151 females with a median age of 64 years (31 - 88).…”

Section: Resultsmentioning

confidence: 99%

To Resect or Not to Resect Extrahepatic Bile Duct in Gallbladder Cancer?

2017

View full text Add to dashboard Cite

The indications for and limitations of extrahepatic bile duct resection (EHBDR) in the context of gallbladder (GB) cancer are unclear. The purpose of this review was to examine the current literature to determine the impact of EHBDR on loco-regional recurrence and survival in GB cancer. The EMBASE and Medline databases were searched up to February 2016 using the terms: extrahepatic bile duct resection and gallbladder cancer. Studies published in the last 20 years were eligible for inclusion. Given the heterogeneity of the population and the study methodologies employed, qualitative data synthesis in the form of meta-analysis was deemed implausible. Twenty-four studies fulfilled the inclusion criteria. The selected studies include 6,722 (55%) EHBDRs in a total of 12,251 GB cancer operations. The 25 studies were categorized into seven groups: 1) cancer survival all stages; 2) hepatoduodenal ligament invasion; 3) outcome in EHBDR and EHBDNR; 4) pT1b tumors; 5) pT2 tumors; 6) pT3/T4 tumors; and 7) incidental GB cancer. Radical cholecystectomy with EHBDR should be used as a standard operation for tumors involving the neck or the cystic duct of the GB (either macroscopically or microscopically). In all other cases, operative strategy should be individualized to the patient.

show abstract

“…18 When discovered intra-operatively, the procedure should be aborted and the patient should be transferred to a hepatobiliary center. Outcomes of patients with an incidental finding of gallbladder cancer have a better prognosis than non-incidentally-discovered disease, provided the patient is staged and managed appropriately with R0 resection.…”

Section: Incidental Gallbladder Carcinomamentioning

confidence: 99%