Incidental late diagnosis of cystic fibrosis following AH1N1 influenza virus pneumonia: a case report

Iadevaia, Carlo; Iacotucci, Paola; Carnovale, Vincenzo; Calabrese, Cecilia; Rea, Gaetano; Ferrara, Nicola; Perrotta, Fabio; Mazzarella, Gennaro; Bianco, Andrea

doi:10.1186/s13256-017-1430-0

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Although this discordance makes our understanding of host–pathogen interaction during exacerbations more complicated, it opens new conceptual views, where different CF subjects could manifest exacerbations due to: (i) an increase in the amount of a specific pathogen; (ii) a switch in the metabolic activity of a specific bacterial family; (iii) some anaerobic bacteria that are not normally associated with the disease state that can act as pathogens under particular conditions [ 28 ]. Therefore, although a late diagnosis of CF is rare nowadays [ 29 ], an early assessment of the disease in association with lung microbiome composition could reduce the occurrence of complications later in life.…”

Section: How Does the Lung Microbiome In Cf Patients Change With Amentioning

confidence: 99%

Lung Microbiome in Cystic Fibrosis

Scialò

Amato

Cernera

et al. 2021

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The defective mucociliary clearance due to CFTR malfunctioning causes predisposition to the colonization of pathogens responsible for the recurrent inflammation and rapid deterioration of lung function in patients with cystic fibrosis (CF). This has also a profound effect on the lung microbiome composition, causing a progressive reduction in its diversity, which has become a common characteristic of patients affected by CF. Although we know that the lung microbiome plays an essential role in maintaining lung physiology, our comprehension of how the microbial components interact with each other and the lung, as well as how these interactions change during the disease’s course, is still at an early stage. Many challenges exist and many questions still to be answered, but there is no doubt that manipulation of the lung microbiome could help to develop better therapies for people affected by CF.

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Section: How Does the Lung Microbiome In Cf Patients Change With Amentioning

confidence: 99%

Lung Microbiome in Cystic Fibrosis

Scialò

Amato

Cernera

et al. 2021

Life

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Evaluation of Allergic Diseases, Symptom Control, and Relation to Infections in a Group of Italian Elite Mountain Bikers

Perrotta

Simeon

Bonini

et al. 2020

Clinical Journal of Sport Medicine

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Objectives: This study estimates the prevalence of allergic diseases in a group of Italian elite mountain bikers, compares the prevalence of infectious episodes between allergic and nonallergic athletes, and evaluates asthma and rhinitis symptom control in allergic athletes. Design: Two hundred twenty-six Italian nonsmoking mountain bikers received by mail the Allergy Questionnaire for Athletes (AQUA) and completed it. The RhinAsthma Patient Perspective (RAPP) questionnaire was sent to the 108 participants with a positive AQUA score and 104 returned the questionnaire. Methods: Athletes with an AQUA score ≥5 or <5 were defined AQUA+ (allergic) or AQUA− (nonallergic), respectively. RhinAsthma Patient Perspective questionnaire total score ≥15 was indicative of a poor control of symptoms. Results: Of the 226 athletes, 47.8% were AQUA+, whereas 52.2% were AQUA−. A higher number of AQUA+ athletes reported frequent upper respiratory tract infections (URTIs) and herpes labialis than AQUA− athletes (P < 0.001), and the prevalence of URTI was greater in the subgroup of AQUA+ athletes who trained ≥3 hours per session. According to RAPP questionnaire score, 21.1% of AQUA+ mountain bikers had a poor control of asthma and rhinitis symptoms. Conclusions: Our study shows a high prevalence of allergy among Italian elite mountain bikers whose asthma and rhinitis symptoms are poorly controlled in about a fifth of the sample. Allergic athletes, mainly those training more than 3 hours per session, are at higher risk of URTI and herpes labialis. Screening programs to detect allergic diseases and to evaluate symptom control in athletes should be strongly encouraged.

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Incidental late diagnosis of cystic fibrosis following AH1N1 influenza virus pneumonia: a case report

Cited by 2 publications

References 23 publications

Lung Microbiome in Cystic Fibrosis

Lung Microbiome in Cystic Fibrosis

Evaluation of Allergic Diseases, Symptom Control, and Relation to Infections in a Group of Italian Elite Mountain Bikers

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