Incidental pancreatic cysts: natural history and diagnostic accuracy of a limited serial pancreatic cyst MRI protocol

Nougaret, Stéphanie; Reinhold, Caroline; Chong, Jaron; Escal, Laure; Mercier, Grégoire; Fabré, J; Guiu, Boris; Molinari, Nicolas

doi:10.1007/s00330-014-3112-2

Cited by 64 publications

(52 citation statements)

References 26 publications

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“…Moreover, diagnosis was often assumed by imaging and/or follow up without pathologic confirmation of the cyst type (21,22, 24-26). However, as recently described, pancreatic cysts changes by imaging are not evident in a short-time follow-up (30). Given the limitations listed above, it is difficult to draw any conclusions regarding DWI in pancreatic cysts.…”

Section: Introductionmentioning

confidence: 60%

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Pozzessere

Gutiérrez

Corona‐Villalobos

et al. 2016

Journal of Computer Assisted Tomography

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Objective To evaluate the feasibility and the reproducibility of diffusion-weighted imaging (DWI) in distinguishing between mucin-producing and serous pancreatic cysts. Methods Forty-four pancreatic cysts (43 patients; 27 females; mean age 57 years-old; 26 mucin-producing cysts; 18 serous cysts) underwent histological examination or cyst analysis after DW-MRI were retrospectively reviewed. Three blinded readers independently evaluated SI and ADC. Intra-observer and inter-observer agreements were calculated. Fisher's exact test and Welch's t test were used to compare SI and ADC values respectively, to pathological results. ROC analysis was used to determine diagnostic accuracy of various thresholds for ADC. A p value < 0.05 was considered statistically significant. Results Mean ADC value of the mucin-producing cysts was 3.26 ×10−3 mm2/sec, 3.27 ×10−3 mm2/sec and 3.35 ×10−3 mm2/sec for the three readers, respectively. Mean ADC value of the serous cysts was 2.86 ×10−3 mm2/sec, 2.85 ×10−3 mm2/sec and 2.85 ×10−3 mm2/sec for the three readers, respectively. Difference in ADC values between the two cyst groups was 12.4%, 12.9% and 14.8% for the three readers, respectively (p<0.001). Intra-observer and inter-observer agreement was excellent. A threshold ADC of 3×10−3 mm2/sec resulted in correct identification of cysts in 77-81% of cases, with sensitivity and specificity ranging between 84-88% and 66-72%, respectively. Conclusions DWI may be a helpful tool in distinguishing between mucin-producing and serous pancreatic cysts.

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Section: Introductionmentioning

confidence: 60%

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Pozzessere

Gutiérrez

Corona‐Villalobos

et al. 2016

Journal of Computer Assisted Tomography

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“…Also, MRCP seems to carry lower risk of undesirable effects secondarily to contrast administration (63).…”

Section: Imaging Studiesmentioning

confidence: 99%

Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations

Moris

Wallace

2017

Rev Esp Enferm Dig

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The real prevalence of pancreatic cystic lesions remains unknown. The malignant potential of some of these lesions remains a cause for significant concern. Thus, it is mandatory to develop a strategy to clearly discriminate those cysts with a potential for malignant transformation from those that do not carry any significant risk. Intraductal papillary mucinous neoplasms and mucinous cystadenomas are mucinous cystic neoplasms with a known malignant potential that have gained greater recognition in recent years. However, despite the numerous studies that have been carried out, their differential diagnosis among other cysts subtypes and their therapeutic approach continue to be a challenge for clinicians. This review contains a critical approach of the current recommendations and management strategies regarding intraductal papillary mucinous neoplasms and mucinous cystadenomas, as well as highlighting the limitations exposed in current guidelines.

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“…Additionally, confirming enhancement is crucial for assessment of suspected MN/SC. If non-contrast MR imaging is used to follow up patients with IPMN [22,23], further evaluation with contrast-enhanced CT or MRI may be valuable when the presence of MN or SC is suspected.…”

Section: Discussionmentioning

confidence: 99%

Imaging comparison of tubular and colloid pancreatic adenocarcinoma arising from intraductal papillary mucinous neoplasm on multidetector CT

et al. 2016

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Purpose To compare tubular and colloid subtype pancreatic ductal adenocarcinomas (PDAC) associated with intraductal papillary mucinous neoplasms (IPMN) on CT. Methods An IRB approved retrospective study included patients with either IPMN tPDAC or cPDAC. Enhancing mural nodules (MN), solid component (SC), main pancreatic duct diameter (MPD), abrupt change in MPD caliber were evaluated. Results 22 patients with cPDAC, 17 with tPDAC showed no significant difference in MPD size. MN and SC were seen in cPDAC/tPDAC in 55%/18% and 9%/53% respectively. Abrupt change in MPD caliber was seen in cPDAC/tPDAC at 18%/59%. Conclusion Colloid and tubular PDAC differ in the frequency of MN, SC and changes in MPD caliber.

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Incidental pancreatic cysts: natural history and diagnostic accuracy of a limited serial pancreatic cyst MRI protocol

Cited by 64 publications

References 26 publications

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations

Imaging comparison of tubular and colloid pancreatic adenocarcinoma arising from intraductal papillary mucinous neoplasm on multidetector CT

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