Incision Wound Healing Test of Ethanolic Extract Gel from Salaon (Parsonsia alboflavescens [Dennst.] Mabb.) Leaves in Male Rats

Zebua, Nilsya Febrika; Saputri, Muharni; Sijabat, Winda Giovana; Wulandari, Inda Aristika Sri Retno; Nofriani, Ira; Zai, Winda Agustiani; Arista, Ramadani Arda; Suhaimi, Muhammad; Firsa, Aula

doi:10.3889/oamjms.2021.6662

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…22 Sediaan stabil jika tidak terjadi perubahan warna dan perubahan bentuk setelah penyimpanan selama tiga siklus. 23 Data dianalisis dengan menggunakan program SPSS versi 26 dan dilanjutkan dengan uji normalitas. Uji statistik yang digunakan untuk menguji asumsi normalitas adalah dengan menggunakan uji normalitas Shapiro-wilk atau Kolmogorov-Smirnov.…”

Section: Gel Diproduksi Menggunakan Gelling Agentunclassified

Optimasi Formula Gel Antioksidan dengan Ekstrak Labu Kuning (Cucurbita maxima) sebagai Bahan Aktif

Maulidini,

Nian,

Nurlaeli

2023

J Integr Kes Sains

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Kerusakan kulit wajah merupakan salah satu permasalahan utama yang sering dirasakan manusia. Salah satu penyebabnya adalah paparan sinar matahari yang mengandung radikal bebas. Buah labu kuning (Cucurbita maxima) adalah satu dari sekian banyak buah-buahan yang mengandung antioksidan tinggi dan manfaat yang baik untuk mencegah kerusakan kulit. Tujuan penelitian ini adalah menganalisis pengaruh formulasi sediaan gel ekstrak buah labu kuning terhadap stabilitas fisik dan mengetahui konsentrasi terbaik ekstrak buah labu kuning pada sediaan gel. Metode penelitian meliputi determinasi tanaman, pengumpulan tanaman, pembuatan ekstrak buah labu kuning, pembuatan sediaan gel, dan evaluasi sediaan secara fisika. Penelitian dilakukan di Laboratorium Botani Badan Riset dan Inovasi Nasional (BRIN) Cibinong Kabupaten Bogor pada tahun 2021. Data hasil percobaan dianalisis dengan menggunakan program SPSS versi 26. Hasil penelitian ini ditemukan bahwa ekstrak labu kuning dapat diformulasikan menjadi sediaan gel yang ditunjukkan dengan parameter uji homogenitas, sediaan ini memiliki susunan yang homogen baik sebelum dan setelah uji stabilitas freeze-thaw. Konsentrasi terbaik ekstrak labu kuning berada pada rentang 3% berdasarkan parameter uji organoleptik. Gel ekstrak labu kuning memiliki nilai daya lekat dan sebar yang belum memenuhi persyaratan, tetapi parameter homogenitas, organoleptik, pH, viskositas, dan uji stabilitas menyatakan bahwa gel dari ekstrak labu kuning memiliki kualitas yang baik. Gel ekstrak labu kuning menunjukkan stabilitas yang baik sebelum dan setelah uji stabilitas freeze-thaw selama tiga siklus. Hasil ini menunjukkan bahwa ekstrak labu kuning dapat diformulasikan menjadi sediaan gel.

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Section: Gel Diproduksi Menggunakan Gelling Agentunclassified

Optimasi Formula Gel Antioksidan dengan Ekstrak Labu Kuning (Cucurbita maxima) sebagai Bahan Aktif

Maulidini,

Nian,

Nurlaeli

2023

J Integr Kes Sains

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Characterization and Anti-aging Tests of Peel-Off Gel Masks Made from Ethanolic Extract of Yarrow (Achillea millefolium)

Syakri

Ismail²,

Masjidi

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Yarrow extract (Achillea millefolium) is recognized to have powerful antioxidants that protect the skin from free radical damage, skin whitening, and anti-aging properties. As a result, the application of antioxidants on the skin can be packaged into a peel-off gel mask preparation for face skin care. AIM: The goal of this study is to see how different concentrations of PVA and HPMC as film-forming and gelling agents affect the quality of peel-off gel masks made from ethanol extract of yarrow (Achillea millefolium) as an antiaging ingredient. METHODS: In order to obtain 5 formulas that will be made into preparations and evaluate the quality of the preparations, this research method uses quantitative analysis methods and statistical analysis using One Way ANOVA by varying the concentrations of PVA (7-10%) and HPMC (2-4%) in order to obtain 5 formulas that will be made into preparations and evaluated the quality of the preparations. Organoleptic, homogeneity, pH, syneresis, skin irritation, viscosity, spreadability, and drying time of the mask were all evaluated. RESULT: The results of the experiment with different concentrations of PVA and HPMC enhanced dispersion and drying time, but had no effect on the viscosity value decrease. CONCLUCION: The quality of the peel off gel mask prepared from the ethanol extract of Yarrow was significantly affected by PVA and HPMC concentrations (p<0.05).

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Wound Healing Activity of Nanoemulgel Containing Artocarpus lakoocha Roxb. Extract on Burns Model in Rat

Tanjung

Silalahi²,

Reveny

2022

Open Access Maced J Med Sci

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BACKGROUND: The content of secondary metabolites in mobe leaves has the potential to be used in wound healing. Artocarpine, one of the secondary metabolites found in mobe leaves, is reported to affect the expression of transforming growth factor-beta (TGF-β) protein, thereby increasing fibroblast cell proliferation and accelerating the wound healing process. AIM: This study aims to determine the wound healing activity of nanoemulgel-containing ethanol extract of mobe leaves. MATERIALS AND METHODS: The method used in this study was experimental using chemicals ethanol 96%, Carbopol 940, PEG 400, Propylene glycol, Methyl Paraben, Propyl Paraben, Triethanolamine, Aqua Destillata. Mode leaves which were taken purposively were then formulated in nanoemulgel preparations which were tested for wound healing in male rats. The nanoemulgel preparation was then evaluated which included homogeneity, emulsion type, pH, viscosity, dispersion, and measurement of the nanoemulgel globules of mobe leaf extract, stability of the nanoemulgel preparation. Tests for the healing effect of burns were carried out on male rats for 14 days. RESULTS: Mobe leaves ethanol extract can be formulated into nanoemulgel dosage forms. This study showed wound healing activity of nanoemulgels with concentration variation of mobe leaves ethanol extract. The percentage of wound diameter reducing and fibroblast cells value were showed to increase and significantly different to negative control (p < 0.05) in 14 days. Platelet-derived growth factor (PDGF)-BB and TGF-β1 immunoexpression evaluation result showed significantly different to Blanko group (p < 0.05) in 14-day observation. CONCLUSION: From this study, nanoemulgel mobe can stimulate more fibroblast cell proliferation by greatly expressing TGF-β1 and PDGF BB in burn wounds.

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Incision Wound Healing Test of Ethanolic Extract Gel from Salaon (Parsonsia alboflavescens [Dennst.] Mabb.) Leaves in Male Rats

Cited by 3 publications

References 14 publications

Optimasi Formula Gel Antioksidan dengan Ekstrak Labu Kuning (Cucurbita maxima) sebagai Bahan Aktif

Optimasi Formula Gel Antioksidan dengan Ekstrak Labu Kuning (Cucurbita maxima) sebagai Bahan Aktif

Characterization and Anti-aging Tests of Peel-Off Gel Masks Made from Ethanolic Extract of Yarrow (Achillea millefolium)

Wound Healing Activity of Nanoemulgel Containing Artocarpus lakoocha Roxb. Extract on Burns Model in Rat

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