Recent research outputs indicate that despite the considerable efforts exerted in social science to estimate, and potentially eliminate, the social desirability (SD) effect in researching socially sensitive issues, doping research has mainly overlooked the distorting effect of dishonesty. As the SD effect is a result of the interplay between personality and contextual contingencies, it varies greatly between individuals and from one situation to another. Similarly, the drugtesting regime for the most widely abused performance-enhancing substance, anabolic androgenic steroids, does not take into account individual genetic variations that can have profound effects on doping test results. The aims of this article are to highlight some major impediments in doping research and anti-doping strategies; to map the impact our research has made on doping research; and to highlight future directions to advance anti-doping efforts. Our multidisciplinary research effort, benefitting from the synergy between\ social and natural sciences, has created a unique platform for anti-doping research with the view of aiding not only detection, but also harm reduction, intervention and prevention. Benefitting from the synergy between social and analytical sciences, our results have drawn attention to the distorting effect of SD but also made progress in identifying methods to overcome the limitations associated with the sole use of the self-report methodology. These advances in behavioural approaches coupled with improved hair-based analytical methods provide an opportunity to coalesce disparate analytical and social approaches and build on the strengths in each approach and thus inform and strengthen each other.