Incontinence and psychological problems in children: a common central nervous pathway?

Herzeele, Charlotte Van; Walle, Johan Vande

doi:10.1007/s00467-016-3336-2

Cited by 10 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 Thus, the link we observed between inattentive symptoms and subsequent nocturnal enuresis could be due to a common underlying neurological factor, perhaps reflecting delayed maturation or developmental differences of the central nervous system. 29 …”

Section: Discussionmentioning

confidence: 99%

Early Behavioral Risks of Childhood and Adolescent Daytime Urinary Incontinence and Nocturnal Enuresis

Vasconcelos

East

Blanco

et al. 2017

J Dev Behav Pediatr

View full text Add to dashboard Cite

Objective To investigate whether infant temperament and childhood internalizing, externalizing and inattention symptoms increase the likelihood of daytime urinary incontinence or nocturnal enuresis at 10 years and adolescence (11.9 – 17.8 years). Method Data were from a longitudinal cohort of 1,119 healthy Chilean children. We assessed behavioral symptoms at infancy, 5 and 10 years and their relationship with subsequent daytime urinary incontinence and nocturnal enuresis. Results Daytime urinary incontinence and nocturnal enuresis occurred in, respectively, 3.3% and 11% at 10 years, and 1.1% and 2.7% at adolescence. Difficult infant temperament was associated with increased odds of 10-year daytime urinary incontinence. Inattention at 5 years was associated with increased odds for nocturnal enuresis at 10 years and adolescence. Internalizing and externalizing symptoms at 5 years were associated with increased odds of 10-year daytime urinary incontinence and nocturnal enuresis. Internalizing and externalizing symptoms at 10 years were associated with adolescent nocturnal enuresis. Conclusion Temperament and internal/externalizing symptoms may be risk factors for school-age and adolescent urinary incontinence.

show abstract

Section: Discussionmentioning

confidence: 99%

Early Behavioral Risks of Childhood and Adolescent Daytime Urinary Incontinence and Nocturnal Enuresis

Vasconcelos

East

Blanco

et al. 2017

J Dev Behav Pediatr

View full text Add to dashboard Cite

show abstract

“…There are also data supporting a common underlying CNS disturbance, maybe involving the pontine reticular activating system (see below) …”

Section: Psychiatry and Psychologymentioning

confidence: 99%

“…There are also data supporting a common underlying CNS disturbance, maybe involving the pontine reticular activating system (see below). 74,75 Furthermore, it has been observed that psychiatric comorbidity might be especially common among children with secondary enuresis; that is, those who have started wetting again after a dry interval. 76,77 Many families see significant events in the child's life, such as the birth of a sibling or parental separation, as triggers for the recurrence of the enuresis.…”

Section: Psychiatry and Psychologymentioning

confidence: 99%

Pathogenesis of enuresis: Towards a new understanding

Nevéus

2017

Int J of Urology

View full text Add to dashboard Cite

Abbreviations & Acronyms ADHD = attention deficit hyperactivity disorder CNS = central nervous system LC = locus coeruleus PAG = periaqueductal gray area PMC = pontine micturition center Abstract: Enuresis was historically viewed as a primarily psychiatric disorder, but this understanding has changed dramatically since the end of the last century, when it became clear that somatic factors, such as nocturnal polyuria as a result of vasopressin deficiency, nocturnal detrusor overactivity and high arousal thresholds, all play a crucial role in enuresis pathogenesis. It has also become clear that enuresis is inherited in the majority of cases, although the correlation between genotype and enuretic phenotype is not straightforward. The standard view of enuresis as being the result of either (i) nocturnal polyuria and high arousal thresholds; or (ii) nocturnal detrusor overactivity and high arousal thresholds has become well-established, but further research now complicates the picture. First, psychological/psychiatric problems are overrepresented in enuresis, and might in a minority of cases have a causal or aggravating role. Second, nocturnal polyuria is not always linked to vasopressin deficiency. Third, nocturnal detrusor overactivity is in itself pathogenetically heterogeneous, and could be linked to constipation. Fourth, the sleep of enuretic children might be "deep," but possibly also disturbed (by obstructed airways or a distended or contracting bladder). These children might have high arousal thresholds because of the enuresis instead of the other way around. The same might possibly be said about nocturnal polyuria. Taking these new insights into account, a new model of enuresis pathogenesis is presented, which is more complicated but hopefully also more true than the standard consensus.

show abstract

“…47 Furthermore, Van Herzeele et al proposed that nocturnal enuresis and psychological disorders may share a common central nervous pathway based on the coexistence of these problems. 48 Maturational delays of the central nervous system Global central nervous system maturation delay is considered to be another contributor to nocturnal enuresis, and neuroelectrophysiological evidence also supports this hypothesis. Given that arousal and the micturition reflex are both mediated by nuclei in the brainstem, Freitag et al evaluated the brainstem deficits underlying nocturnal enuresis by measuring evoked potentials (brainstem auditory evoked potential, visual evoked potential, eventrelated late acoustic-evoked potential [P300]), and the pre-pulse inhibition of the startle reflex.…”

Section: Neuropsychological Factorsmentioning

confidence: 99%

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

Dang

Tang

2021

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Nocturnal enuresis is a common and distressing developmental disease, which may cause various degrees of psychosocial stress and impairment to self-esteem in affected children as well as agitation to their parents or caregivers. Nevertheless, the etiology and pathogenesis of nocturnal enuresis are not understood. Currently, nocturnal enuresis is generally considered a multifactorial disease associated with a complex interaction of somatic, psychosocial, and environmental factors. A variety of postulations have been proposed to explain the occurrence and progression of nocturnal enuresis, including hereditary aberration, abnormal circadian rhythm of antidiuretic hormone secretion during sleep, bladder dysfunction, abnormal sleep, difficulties in arousal, neuropsychological disorders, and maturational delays of the brain. In recent decades, the introduction of functional neuroimaging technologies has provided new approaches for uncovering the mechanisms underlying nocturnal enuresis. The main neuroimaging modalities have included brain morphometry based on structural magnetic resonance imaging (MRI), task-based and event-related functional MRI (fMRI), and resting-state fMRI. The relevant studies have indicated that nocturnal enuresis is associated with functional and structural alterations of the brain. In this review, we briefly summarized the popular hypotheses regarding the pathogenesis of nocturnal enuresis and the current progress of functional neuroimaging studies in examining the underlying mechanisms thereof.

show abstract

Incontinence and psychological problems in children: a common central nervous pathway?

Cited by 10 publications

References 18 publications

Early Behavioral Risks of Childhood and Adolescent Daytime Urinary Incontinence and Nocturnal Enuresis

Early Behavioral Risks of Childhood and Adolescent Daytime Urinary Incontinence and Nocturnal Enuresis

Pathogenesis of enuresis: Towards a new understanding

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

Contact Info

Product

Resources

About