Oxadiazon [2-tert-buty1-4-(2, 4-dichloro-5-Isopropoxyphenyl)-~2-1,3,4-oxadiazolin-5-one] was applied alone as a preemergence treatment and in combination with dinoseb (2-sec-butyl-4,6-dinitrophenol) as a crackingtime treatment to peanuts (Arachis hypogaea L.). During the years 1970 to 1972 the experimental area was heavily infested with a mixed population of annual grass and broadleaf weeds. During the years 1973 to 1975, the predominant species present were sicklepod (Cassia obtusifolia L.) and Florida beggarweed [Desmodium tortuosum (Sw.) D.C.]. Grass control was acceptable with 3.36 kg/ha of oxadiazon in 2 of the 3 years when benefin (N-butyl-N-ethyla:, a: , a:-trifluoro-2, 6-dinitro-p-toluidine) was not included. Commercially acceptable control of Florida beggarweed and sicklepod occurred with application of 3.36 kg/ha of oxadiazon. Substantial control was obtained with an application of 1.68 kg/ha. Generally, the addition of 1.68 kg/ha dinoseb to oxadiazon resulted in slightly improved weed control, particularly at lower rates of oxadiazon. Oxadiazon at rates of 6.7 kg/ha or more was phytotoxic to peanuts during the early part of the growing season. This phytotoxicity generally did not result in lower peanut yields. However, treated plants were more compact. Chemical weed control in peanuts dates from the late 1940's when extensive research with herbicides was begun. Several reviews (4, 7, 8, 9) consider the performance of many herbicides for weed control in peanuts.