“…16 In 2014, nearly half of all aesthetic patients in the US who requested MIPs received multiple procedures. 4 Indeed, combination treatments offer an optimal response to the multifactorial process of facial ageing, which involves structural changes in all anatomical layers (bone, muscles, ligaments, adipose tissue, and skin) and dynamic interactions among these tissues. 2,17,18 Consequently, the modern concept of natural and harmonious rejuvenation is based on a comprehensive, threedimensional, multi-layered approach, combining multiple agents and techniques to attain multiple goals such as relaxation, volumisation, volume repositioning, reshaping, resurfacing, or tightening, depending on specific patient needs.…”