Incorporating platelet-rich plasma into coaxial electrospun nanofibers for bone tissue engineering

Ma, Xiao; Li, Junmei; Cheng, Gu; Cao, Yan; Wang, Ziming; Shi, Xiaowen; Du, Yong; Deng, Hongbing; Li, Zubing

doi:10.1016/j.ijpharm.2018.06.020

Cited by 70 publications

(46 citation statements)

References 52 publications

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“…This increase was explained with the superior release of growth factors from the PRP, which promoted the hMSCs proliferation. In vivo testing demonstrated the PRP-loaded scaffolds to instigate new bone formation and the expression of Col II within bone defected sites, after 4 weeks' post-surgery [123]. PRP has also been incorporated within PVA/poly(ether sulfone) (PES) composite scaffolds (PVA/PES/PRP) and its influence on the osteogenic differentiation of human adipose-derived mesenchymal stem cells was followed.…”

Section: Bonementioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

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Section: Bonementioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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“…In the context of regenerative medicine, PRP is not used as cells to differentiate into tissues, but as a DDS for signaling molecules [102,103]. Cheng et al [104] repaired a critical-size cranial defect in a rat model using an implant comprised of a silk fibroin/PCL composite scaffold with PRP.…”

Section: Biodegradable Scaffolds As Drug Delivery Systemsmentioning

confidence: 99%

Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

Aoki

2020

Pharmaceutics

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Regenerative medicine has been widely researched for the treatment of bone defects. In the field of bone regenerative medicine, signaling molecules and the use of scaffolds are of particular importance as drug delivery systems (DDS) or carriers for cell differentiation, and various materials have been explored for their potential use. Although calcium phosphates such as hydroxyapatite and tricalcium phosphate are clinically used as synthetic scaffold material for bone regeneration, biodegradable materials have attracted much attention in recent years for their clinical application as scaffolds due their ability to facilitate rapid localized absorption and replacement with autologous bone. In this review, we introduce the types, features, and performance characteristics of biodegradable polymer scaffolds in their role as DDS for bone regeneration therapy.

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“…These growth factors do not act as cells that differentiate into tissues, but rather serve as a DDS for signaling molecules [88,89]. Using a silk fibroin/PCL composite implant with PRP that was fabricated using electrospinning, Cheng et al repaired critical-sized calvarial bone defects in rats [90].…”

Section: Cells For Bone Regeneration and Signaling Moleculesmentioning

confidence: 99%

The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration

2020

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There has been an increasing amount of research on regenerative medicine for the treatment of bone defects. Scaffolds are needed for the formation of new bone, and various scaffolding materials have been evaluated for bone regeneration. Materials with pores that allow cells to differentiate into osteocytes are preferred in scaffolds for bone regeneration, and porous materials and fibers are well suited for this application. Electrospinning is an effective method for producing a nanosized fiber by applying a high voltage to the needle tip containing a polymer solution. The use of electrospun nanofibers is being studied in the medical field, and its use as a scaffold for bone regeneration therapy has become a topic of growing interest. In this review, we will introduce the potential use of electrospun nanofiber as a scaffold for bone regenerative medicine with a focus on carbon nanofibers produced by the electrospinning method.

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Incorporating platelet-rich plasma into coaxial electrospun nanofibers for bone tissue engineering

Cited by 70 publications

References 52 publications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration

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