Incorporation of 10-hydroxycamptothecin nanocrystals into zein microspheres

Liu, Guijin; Li, Shaomin; Yu, Huang; Wang, Hongdi; Jiang, Yanbin

doi:10.1016/j.ces.2016.08.029

Cited by 33 publications

(26 citation statements)

References 47 publications

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“…10-Hydroxycamptothecin (HCPT) has shown relatively low toxicity and displayed signicant broad-spectrum antitumor activity against various types of cancers, such as breast cancer, lung cancer, hepatoma, leukemia, colorectal cancer and gastric carcinoma. [41][42][43] However, HCPT is a hydrophobic drug and also sensitive to pH changes, both of which properties make it difficult to prepare the desired nanoparticles. 44 In our study, HCPT as another model chemotherapy drug was encapsulated into the CMC-UA NPs by self-assembly for combination therapy (Fig.…”

Section: Self-assembled Cmc-ua/hcpt Nanoparticles and Drug Encapsulationmentioning

confidence: 99%

Self-assembled nanoparticles based on a carboxymethylcellulose–ursolic acid conjugate for anticancer combination therapy

Liu

et al. 2017

RSC Adv.

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Section: Self-assembled Cmc-ua/hcpt Nanoparticles and Drug Encapsulationmentioning

confidence: 99%

Self-assembled nanoparticles based on a carboxymethylcellulose–ursolic acid conjugate for anticancer combination therapy

Liu

et al. 2017

RSC Adv.

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“…In an earlier study, a novel built-in ultrasonic dialysis process (BUDP) was employed to fabricate zein microspheres [ 129 ]. The strategy was further applied to encapsulate 10-hydroxychamptothecin [ 130 ]. A combinatorial methodology involving the supercritical antisolvent and this built-in ultrasonic dialysis approach was applied to obtain FA-zein nanoparticles carrying 10-hydroxychamptothecin nanocrystals [ 94 ].…”

Section: Surface Modified Zein Nanoparticles For Active Targeted Drug Deliverymentioning

confidence: 99%

Surface-Tailored Zein Nanoparticles: Strategies and Applications

et al. 2021

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Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

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“…PVP belongs to this category of polymers; indeed, its use allowed to increase the dissolution rate of various poorly-water soluble active compounds [8,9,11,31,33,65,70,81,93,94,97,[115][116][117]. In reverse, the drug release is prolonged using a polymer with a hydrophobic behavior, as occurs, for example, by selecting zein [17,[46][47][48][49]. Similarly, a sustained or prolonged release of the active compound was observed from particles based on polylactic acid (PLA) and poly (L-lactic acid) (PLLA) [32,67,98,99,111,112,[118][119][120][121], which, until now, has been mostly employed to deliver anticancer drugs.…”

Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

“…Recently, some changes to the SAS process have been suggested [13,47]. In particular, Matos et al [13] proposed a single-step coprecipitation and coating by using the supercritical antisolvent.…”

Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

“…The dissolution kinetics of many active principles, both of synthetic and natural origin, have been successfully modified by selecting carriers suitable for the required therapy. Different biopolymers, which are biocompatible [11,22,43,44] and sometimes even biodegradable [32,[45][46][47][48][49], have been studied to tune the release of the active compounds. In literature, there are few reviews about the SAS technique [50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

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Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

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Incorporation of 10-hydroxycamptothecin nanocrystals into zein microspheres

Cited by 33 publications

References 47 publications

Self-assembled nanoparticles based on a carboxymethylcellulose–ursolic acid conjugate for anticancer combination therapy

Self-assembled nanoparticles based on a carboxymethylcellulose–ursolic acid conjugate for anticancer combination therapy

Surface-Tailored Zein Nanoparticles: Strategies and Applications

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

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