Incorporation of anti-inflammatory agent into mesoporous silica

Abstract

The unique properties of macroporous, mesoporous, and microporous systems, including their ability to accommodate molecules of different sizes inside their pores and to act as drug delivery systems, have been the object of extensive studies. In this work, mesoporous silica with hexagonal structure was obtained by template synthesis via the sol-gel process. The resulting material was used as support to accommodate the anti-inflammatory agent indomethacin. The alkaline route was used to prepare the mesoporous silica; cetyltrimethylammonium bromide was employed as porogenic agent. The silica particles were functionalized with 3-aminopropyltriethoxysilane alkoxide (APTES) by the sol-gel post-synthesis method. Indomethacin was incorporated into the silica functionalized with APTES and into non-functionalized silica. The resulting systems were characterized by x-ray diffraction (XRD), specific area, infrared spectroscopy, and thermal analyses (TGA). XRD attested to formation of mesoporous silica with hexagonal structure. This structure remained after silica functionalization with APTES and incorporation of indomethacin. Typical infrared spectroscopy vibrations and organic material decomposition during TGA confirmed silica functionalization and drug incorporation. The specific surface area and pore volume of the functionalized material incorporated with indomethacin decreased as compared with the specific surface area and pore volume of the non-functionalized silica containing no drug, suggesting both the functionalizing agent and the drug were present in the silica. Cytotoxicity tests conducted on normal fibroblasts (GM0479A) cells attested that the silica matrix containing indomethacin was less toxic than the free drug.

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

“…However, on amino functionalization, a relatively prolonged release of the drug was observed due to the strong interaction between the amino groups of silica surface and carboxyl groups of ibuprofen [ 202 ]. Other similar studies were carried out to successfully deliver aspirin [ 155 ] and indomethacin [ 203 ] using MSNs with high drug loading and slow release profile.…”

Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies

“…Surface functionalization using aminosilanes is one of the most commonly used methods for post-synthesis functionalization of mesoporous materials. Grafting aminosilanes to the surface of different porous materials has been executed to improve their performance in CO 2 sorption [23,24], drug delivery [25,26], and catalysis [27]. Surface modification also allows the drug loading and release profile of porous materials to be tuned [28].…”

Biomedical nanomaterials for immunological applications: ongoing research and clinical trials

“…Braz et al loaded MSN with the anti-inammatory drug indomethacin and showed that the MSN-drug complex signicantly lowered the in vitro cytotoxicity compared to the free form of the drug. 81 These MSN-based systems can be further improved, for example by using coatings such as ethylcellulose, which prolongs the drug release. 82 Additionally, it can be modied for stimuli-responsive drug release by e.g.…”