Incorporation of C60 into artificial lipid membranes

Hungerbuehler, Hartmut; Guldi, Dirk M.; Asmus, K.‐D.

doi:10.1021/ja00061a070

Cited by 193 publications

(168 citation statements)

References 0 publications

Supporting

Mentioning

152

Contrasting

Order By: Relevance

“…Such conclusion is supported by corresponding findings in Langmuir-Blogett films of fullerene in phenolic aqueous solution of vapour deposition films of C 60 on polar solid material [32], as well as by the work of Hungerbüehler et al [25].…”

Section: Micellar Solubilization Of C 60 -Localization In the Micellasupporting

confidence: 62%

“…The UV-VIS spectrum of C 60 in toluene contains a characteristic band at 335 nm and small sharp peak at 407 nm [25,20]. In order to evaluate micellar solubilization of fullerene (27.5 M) and its dependence on a solubilizer concentration, we monitored the absorption spectra of every prepared micellar solution of fullerene in the region from 300 to 600 nm, with special regards on its characteristic band at 335 nm and vibronic structure in the range of 400-410 nm.…”

Section: Micellar Solubilization Of C 60 -Localization In the Micellamentioning

confidence: 99%

“…These findings open the possibility for transferring individual molecules of fullerene to biological cells via liposome interaction with cell membrane. Other macromolecules such as calixarene [21], polyvinylpyrrolidone (PVP) [22][23][24], lecithin [25] have been used to prepare water stable C 60 aggregates. Surfactant solutions also offer a versatile solubilization method, since the micellar environment is chemically inert towards fullerenes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solubilization of fullerene C60 in micellar solutions of different solubilizers

Torres

Poša

Srdjenović

et al. 2011

Colloids and Surfaces B: Biointerfaces

112

View full text Add to dashboard Cite

a b s t r a c tFullerene (C 60 ), the third carbon allotrope, is a classical engineered material with the potential application in biomedicine. However, extremely high hydrophobicity of fullerene hampers its direct biomedical evaluation and application. In this work, we investigated the solubilization of fullerene using 9 different solubility enhancers: Tween 20, Tween 60, Tween 80, Triton X-100, PVP, polyoxyethylene (10) lauryl ether, n-dodecyl trimethylammonium chloride, myristyl trimethylammonium bromide and sodium dodecyl sulphate and evaluated its antioxidant activity in biorelevant media. The presence of C 60 entrapped in surfactant micelles was confirmed by UV/VIS spectrometry. The efficacy of each modifier was evaluated by chemometric analysis using experimental data for investigating the relationship between solubilization and particle size distribution. Hierarchical clustering and principal component analysis was applied and showed that non-ionic surfactants provide better solubilization efficacy (>85%). A correlation was established (r = 0.975) between the degree of solubilization and the surfactant structure. This correlation may be used for prediction of C 60 solubilization with non-tested solubility modifiers. Since the main potential biomedical applications of fullerene are based on its free radical quenching ability, we tested the antioxidant potential of fullerene micellar solutions. Lipid peroxidation tests showed that the micellar solutions of fullerene with Triton and polyoxyethylene lauryl ether kept high radical scavenging activity, comparable to that of aqueous suspension of fullerene and BHT. The results of this work provide a platform for further solubilization and testing of pristine fullerene and its hydrophobic derivatives in a biological benign environment.

show abstract

Section: Micellar Solubilization Of C 60 -Localization In the Micellasupporting

confidence: 62%

Section: Micellar Solubilization Of C 60 -Localization In the Micellamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solubilization of fullerene C60 in micellar solutions of different solubilizers

Torres

Poša

Srdjenović

et al. 2011

Colloids and Surfaces B: Biointerfaces

112

View full text Add to dashboard Cite

show abstract

“…The band at 450 nm has been previously reported and attributed to aggregation of C 60 within the Triton X-100 micelle. 65,66,79,80 The amount of aggregation is highly dependent on the preparation method of the colloidal suspension. 50,59,81,82 , 100), a linear fit is obtained.…”

Section: Resultsmentioning

confidence: 99%

Photophysical Properties of C₆₀ Colloids Suspended in Water with Triton X-100 Surfactant: Excited-State Properties with Femtosecond Resolution

et al. 2009

View full text Add to dashboard Cite

We examine the photophysics of a colloidal suspension of C 60 particles in a micellar solution of Triton X-100 and water, prepared via a new synthesis which allows high-concentration suspensions. The particle sizes are characterized by transmission electron microscopy and dynamic light scattering and found to be somewhat polydisperse in the range of 10-100 nm. The suspension is characterized optically by UV-vis spectroscopy, femtosecond transient absorption spectroscopy, laser flash photolysis, and z-scan. The ground-state absorbance spectrum shows a broad absorbance feature centered near 450 nm which is indicative of colloidal C 60 . The transient absorption dynamics, presented for the first time with femtosecond resolution, are very similar to that of thin films of C 60 and indicate a strong quenching of the singlet excited state on short time scales and evidence of little intersystem crossing to a triplet excited state. Laser flash photolysis reveals that a triplet excited-state absorption spectrum, which is essentially identical in shape to that of molecular C 60 solutions, does indeed arise, but with much lower magnitude and somewhat shorter lifetime. Z-scan analysis confirms that the optical response of this material is dominated by nonlinear scattering. IntroductionSince its discovery, 1 the uniquely symmetrical C 60 molecule has been widely studied, and many applications for it and its derivatives have been proposed, notably lubricants, 2 superconductors, 3 sensors, 4-7 solar cells, 8 and biomedical applications [9][10][11] such as drug delivery and photodynamic therapy. In particular, the photophysical properties of the C 60 molecule have been the subject of intense study. Many authors have reported on the photophysical properties of molecular solutions of C 60 . [12][13][14][15][16][17][18][19][20] Likewise, many authors have studied the photophysical and structural properties of solid films of C 60 . [21][22][23][24][25][26][27][28][29][30][31][32][33][34] Under certain conditions, C 60 forms stable colloidal assemblies in solvents. [35][36][37][38][39][40][41][42][43][44] Colloidal suspensions of C 60 particles can also be formed in binary solvent mixtures, in which one is a good solvent and the other is a poor solvent for C 60 . [45][46][47][48][49] Aqueous suspensions of colloidal C 60 particles are also formed by a number of methods, [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] including solubilization in micellar solutions. 55,61,[65][66][67][68][69] Some studies have been done of the photophysical properties of these colloidal fullerene suspensions. 67,68,70,71 The photochemical properties, and in particular the generation of reactive oxygen species (ROS) via intersystem crossing to the triplet state, have been of interest both for potential exploitation for photodynamic therapy 9 and regarding concerns about their potential environmental impact, because there have been reports of significant cytotoxicity effects. [50][51][52][53] This work reports on the excited-state dynamics o...

show abstract

“…Choosing an appropriate dispersing agent in the aqueous or organic solution is imperative to avoid chemical damage or the modification of CNTs surfaces and to obtain a stable dispersion of CNTs. [12][13][14][15] Another important issue in the fabrication of CNTs-dispersed composites is CNTs size control. CNTs with relatively short length have attracted strong attraction because they can provide the controlled properties such as strength and toughness for CNTs dispersed composites.…”

Section: Introductionmentioning

confidence: 99%