Incorporation of Cobalt‐Cyclen Complexes into Templated Nanogels Results in Enhanced Activity

Abstract

Recent advances in nanomaterials have identified nanogels as an excellent matrix for novel biomimetic catalysts using the molecular imprinting approach. Polymerisable Co‐cyclen complexes with phosphonate and carbonate templates have been prepared, fully characterised and used to obtain nanogels that show high activity and turnover with low catalytic load, compared to the free complex, in the hydrolysis of 4‐nitrophenyl phosphate, a nerve agent simulant. This work demonstrates that the chemical structure of the template has an impact on the coordination geometry and oxidation state of the metal centre in the polymerisable complex resulting in very significant changes in the catalytic properties of the polymeric matrix. Both pseudo‐octahedral cobalt(III) and trigonal‐bipyramidal cobalt(II) structures have been used for the synthesis of imprinted nanogels, and the catalytic data demonstrate that: i) the imprinted nanogels can be used in 15 % load and show turnover; ii) the structural differences in the polymeric matrices resulting from the imprinting approach with different templates are responsible for the molecular recognition capabilities and the catalytic activity. Nanogel P1, imprinted with the carbonate template, shows >50 % higher catalytic activity than P2 imprinted with the phosphonate.

Toward Catalytic Antibiotics: Redesign of Fluoroquinolones to Catalytically Fragment Chromosomal DNA

“…The complexes were characterized by UV–vis, EPR, and HMRS (see Methods for details). The aqua-hydroxo Co­(III) complexes of 1 – 6 were prepared in three steps according to the reported literature . The initial Co­(III)-CO 3 complexes were characterized by MS, UV–vis, and 13 C NMR, the intermediate Co­(III)-Cl 2 complexes were characterized by UV–vis and HRMS and the aqua-hydroxo-Co­(III) complexes were characterized by UV–vis (see Supporting Information for details).…”

“…The syntheses followed the reported literature procedure with slight changes and included the following three steps:…”

Dynamic Intramolecular Cap for Preserving Metallodrug Integrity─A Case of Catalytic Fluoroquinolones

“…The Co(III) complexes of 7 – 10 were prepared as previously reported 38 with some modifications, as outlined in the Experimental Section . Briefly, the hydrochloride salts of 7 – 10 were treated with a stoichiometric amount of Na 3 [Co(CO 3 ) 3 ]·3H 2 O to directly yield the corresponding Co(III)–aqua–hydroxo complexes.…”

“…The Co(III) complexes of 7–10 were prepared in a two-step process based on a previously reported procedure, 38 with some modifications as follows.…”

“…General Procedure for the Synthesis and Characterization of Co(III) Complexes of 7−10. The Co(III) complexes of 7−10 were prepared in a two-step process based on a previously reported procedure, 38 with some modifications as follows.…”