Incorporation of different crystallizable amide blocks in segmented poly(ester amide)s

Klee

Keul

et al. 2009

Macro Materials & Eng

Novel PEAs derived from 1,4‐butanediol, dimethyl adipate and a preformed α,ω‐amino alcohol were synthesised and successfully electrospun from solution. The effects of increasing the ratio of amide/ester groups in the copolymer, polymer concentration, solvent mixtures and applied voltage on fibre morphology and diameter were investigated. The obtained fibres (diameter 180–450 nm) were randomly oriented. The fibre quality and homogeneity increased with increasing amide concentration. The solvent mixture CHCl3/HCOOH gave the best electrospinning results. The ultra‐fine fibres were characterised using SEM, DSC and FT‐IR, showing that the electrospun fibres are amorphous as compared to the pristine samples. These fibres are potential candidates for use as scaffolds in tissue engineering.magnified image

Section: Introductionmentioning

confidence: 99%

Electrospinning of Novel Poly(ester amide)s

Klee

Keul

et al. 2009

Macro Materials & Eng

“…Tailor-made monomers such as bisamide-diols and diamide-diesters can be condensed with diols and dimethyl adipate to yield segmented/blocky PEAs [70][71][72][73][74][75][76][77]. The uniform amide blocks are randomly distributed in the polyester backbone.…”

Section: Segmented (Blocky) Microstructurementioning

confidence: 99%

“…Such preformed monomers can be condensed with dicarboxylic acids, acid chlorides or esters in solution or melt to yield PEAs. Bisamide diols can be synthesised by reacting diamines with lactones or hydroxy acids in melt or solution [38,39,[70][71][72][73][77][78][79]. In most cases this reaction is accompanied by successive oligomerization of the lactone via the formed hydroxyl groups even in the absence of a catalyst.…”

Section: Synthetic Monomers/building Blocksmentioning

confidence: 99%

Concept and Synthesis of Poly(ester amide)s with One Isolated, Two or Three Consecutive Amide Bonds Randomly Distributed Along the Polyester Backbone

Designed Monomers and Polymers

Keul

Klee

et al. 2009

Poly(ester amide)s (PEAs) were prepared from diols, amino alcohols and diamines with an in-built amide group via polycondensation with 1,4-butanediol and dimethyl adipate. The tailor-made monomers were synthesized by ring opening of ε-caprolactone and ε-caprolactam using 1,4-diaminobutane, 4-aminobutanol and 2-aminoethanol. PEAs having an isolated amide bond or two or three consecutive amide bonds in the poly(butylene adipate) (PBA) backbone, respectively, were obtained via melt polycondensation. The concentration of the amide groups in the PEAs was varied by the amount of preformed α,ω-diamines, amino alcohols or diols introduced in the feed. A simple synthetic route to these preformed monomers and the corresponding PEAs is described. The products were obtained in high purity and high yields.

“…[15,20,21] These PEAs have great potential as biomaterials since the degradation products are water soluble and hence, no crystalline remnants are left behind after degradation. [22] The degradation behaviour as well as the mechanical and thermal properties of such multiphase polymeric materials are determined by their microscopic structure not only in terms of chemical structure and heterogeneity of the chain dynamics, but also by the spatial arrangement of the polymer chains in a given morphology.…”

Section: Introductionmentioning

confidence: 99%

Morphology of Novel PEAs Containing Two Consecutive Amide Bonds Randomly Distributed Along the Polyester Backbone

Macro Chemistry & Physics

Lohakare

Mela

et al. 2010

The morphology of a series of novel segmented PEAs with varying amide content was studied by a combination of DSC, SFM and proton solid state NMR. Semicrystalline polymers organised in a lamellar morphology were obtained for all amide contents. The results of different NMR experiments revealed that a three phase system composed of a rigid phase, an interface and a mobile amorphous phase is the most appropriate model to describe the morphology of these materials. The amount, the chain dynamics and the domain size of each phase were estimated and correlated with the amount of the amide fraction. Such morphological investigations help to understand the macroscopic properties of segmented PEAs for their applications as biomaterials.magnified image