Abstract:Poly(glycerol sebacate) (PGS), a soft, tough elastomer with excellent biocompatibility, has been exploited successfully in many tissue engineering applications. Although tunable to some extent, the rapid in vivo degradation kinetics of PGS is not compatible with the healing rate of some tissues. The incorporation of L-glutamic acid into a PGS network with an aim to retard the degradation rate of PGS through the formation of peptide bonds was conducted in this study. A series of poly(glycerol sebacate glutamate… Show more
“…Jiang et al conducted a synthesis of various poly(glyceryl sebacate glutamate) (PGSE) elastomers, each characterized by a distinct proportioning of sebacic acid and l -glutamic acid. 43 They performed experimental assessments of mechanical properties and enzymatic degradation. The research demonstrated that the introduction of peptide linkages, courtesy of l -glutamic acid, significantly modified the mechanical properties and decelerated the degradation process in PGSE.…”
This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts in balancing degradation with tissue repair for improved applications.
“…Jiang et al conducted a synthesis of various poly(glyceryl sebacate glutamate) (PGSE) elastomers, each characterized by a distinct proportioning of sebacic acid and l -glutamic acid. 43 They performed experimental assessments of mechanical properties and enzymatic degradation. The research demonstrated that the introduction of peptide linkages, courtesy of l -glutamic acid, significantly modified the mechanical properties and decelerated the degradation process in PGSE.…”
This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts in balancing degradation with tissue repair for improved applications.
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