Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress

Alkhatib, Mayson H.; Alyamani, Shaza A; Abdu, Faiza

doi:10.1080/10717544.2020.1736209

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…Anti-inflammatory and antioxidative NEs have been developed as protective and therapeutic formulations for wound healing, and treating neurological, and dermatological diseases [ [166] , [167] , [168] , [169] ]. Anti-inflammatory effects of P-selectin targeted NEs loaded with dexamethasone were studied in animal models.…”

Section: Insights Into Nanoemulsion Drug Delivery Mechanismsmentioning

confidence: 99%

Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks

Tayeb

Felimban

Almaghrabi

et al. 2021

Colloid and Interface Science Communications

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Section: Insights Into Nanoemulsion Drug Delivery Mechanismsmentioning

confidence: 99%

Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks

Tayeb

Felimban

Almaghrabi

et al. 2021

Colloid and Interface Science Communications

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“…Osteoarthritis (OA) and RA are two separate types of arthritis, though [3]. RA and OA both have an impact on the joints, but they are completely different manifestations of the same general condition [4]. A chronic inflammatory (nonsuppurative inflammation) illness involving many collateral joints primarily characterizes RA's clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hydroxychloroquine on markers of oxidative stress and antioxidant reserve in rheumatoid arthritis patients

Ahmed¹,

Althanoon²

2022

J Adv Pharm Educ Res

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“…Genetic susceptibility, diet, alcohol consumption, industrial exposures and air pollution are other factors [ 6 ]. Pulmonary cancer is primarily caused by the abnormal growth of either small or non-small lung cancer cells [ 7 , 8 , 9 , 10 ]. In 2015, 80–85% of cases of lung cancer worldwide were attributed to non-small cell lung cancer (NSCLC) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives

El‐Kalyoubi

Agili

2020

Molecules

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Ethyl 5-arylpyridopyrimidine-6-carboxylates 3a–d were prepared as a one pot three component reaction via the condensation of different aromatic aldehydes and ethyl acetoacetate with 6-amino-1-benzyluracil 1a under reflux condition in ethanol. Additionally, condensation of ethyl 2-(2-hydroxybenzylidene) acetoacetate with 6-amino-1-benzyluracil in DMF afforded 6-acetylpyridopyrimidine-7-one 3e; a facile, operationally, simple and efficient one-pot synthesis of 8-arylxanthines 6a–f is reported by refluxing 5,6-diaminouracil 4 with aromatic aldehydes in DMF. Moreover, 6-aryllumazines 7a–d was obtained via the reaction of 5,6-diaminouracil with the appropriate aromatic aldehydes in triethyl orthoformate under reflux condition. The synthesized compounds were characterized by spectral (1H-NMR, 13C-NMR, IR and mass spectra) and elemental analyses. The newly synthesized compounds were screened for their anticancer activity against lung cancer A549 cell line. Furthermore, a molecular-docking study was employed to determine the possible mode of action of the synthesized compounds against a group of proteins highly implicated in cancer progression, especially lung cancer. Docking results showed that compounds 3b, 6c, 6d, 6e, 7c and 7d were the best potential docked compounds against most of the tested proteins, especially CDK2, Jak2, and DHFR proteins. These results are in agreement with cytotoxicity results, which shed a light on the promising activity of these novel six heterocyclic derivatives for further investigation as potential chemotherapeutics.

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Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress

Cited by 12 publications

References 32 publications

Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks

Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks

Effects of Hydroxychloroquine on markers of oxidative stress and antioxidant reserve in rheumatoid arthritis patients

Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives

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