Incorporation of Novel Elements in Bioactive Glass Compositions to Enhance Implant Performance

Abstract

Increasing popularities of bioactive-glasses and their potential medical applications have led to countless studies into improving their material characteristics and overall performance. Some scientists hope to create new bioactive-glass compositions, while others seek to merely modify existing ones such as the novel 45S5 bioactive-glass composition; created by Dr. Larry Hench. These modifications aim to address potential complications that may arise at a site following implantation such as bacterial infections. In other cases, the incorporation of a selected element or compound may aim to improve the implant functioning by increasing cell proliferation. Although possibilities are plentiful, researchers avoid compromising the typical bioactive glass characteristics when doping with elements such as silver, or gold to achieve additional properties. This chapter elaborates on the incorporation of popular elements by doping bioactive-glass compositions to introduce desired properties based on the implant application.

A review on borate bioactive glasses (BBG): effect of doping elements, degradation, and applications

“…Similarly, it has been demonstrated that Cu-doped BGs and scaffolds promote endothelial cell proliferation and increase mesenchymal stem cell (MSC) differentiation levels. 118,119 To improve bone healing and anti-tumor therapy via the osteogenic properties of Cu, Libin et al 120 recently doped BBG nanoparticles with Cu. According to an in vitro study, the nanoparticle increased endothelial cell angiogenesis as well as the differentiation potential of bone marrow stromal cells (BMSCs).…”

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

“…Moreover, the concentration of the dopant should be determined, because the low dopant concentrations sometimes may not produce the desired properties, and on the contrary, high dopant concentrations may have cytotoxic and carcinogenic effects [ 46 ].…”

Influence of the Addition of Zinc, Strontium, or Magnesium Oxides to the Bioglass 45S5 Network on Electrical Behavior

“…Its remarkable bioactivity, particularly in the context of coating metal implants, exceeds that of conventional biomaterials. The crucial factor to its effectiveness lies in the formation of a strong, carbonated hydroxyapatite layer that mimics the structure of the host bone, ensuring an effective chemical bond and thereby emphasizing the stability of the implant [13,[17][18][19][20]. Moreover, bioglass exhibits inherent osteoinductive and osteogenic properties, stimulating the recruitment and differentiation of human primary osteoblasts, thereby enhancing their proliferation [16,21,22].…”