Incorporation of zinc oxide nanoparticles and it’s antibacterial effect on toothpaste

Abstract

Background Dental caries is the most prevalent oral infection affecting the individuals worldwide, and Streptococcus mutans is the major microorganism involved in its pathology. Thus, the aim was to evaluate the antibacterial effect of addition of nanozinc particles on toothpaste with different concentrations. The study was carried out as Deburdent toothpaste was used as a control group, and nanozinc particles were added with different concentrations to the same toothpaste, and antibacterial test for each group was evaluated. Methods Group 1: (control group) toothpaste only. Group 2: 0.5% of nanozinc particles added to toothpaste. Group 3: 1% of nanozinc particles added to toothpaste. The three groups were incubated for 24 h at 37 °C, and the antibacterial test was tested for all groups using agar well diffusion method. Results All the samples had antibacterial effect against streptococcus mutans. Meanwhile, Group 3 has showed the greatest zone of inhibition compared to the control group showed the lowest effect. Conclusions One % of nanozinc particles were more efficient on Sterptoccocus mutans in comparison with 0.5% nanozinc particles concentration effect.

Nanotechnology in toothpaste: Fundamentals, trends, and safety

“…Both NSF and NaF demonstrated effectiveness in tooth remineralization. ZnONPs [ 104 ] Antimicrobial Addition of ZnO NPs in toothpaste ad concentration of 1 % shows significant antimicrobial activity against Streptococcus mutans NaNbO3/ZnO [ 105 ] Antimicrobial/whitening NaNbO 3 /ZnO effectively degrade organic dyes that covered tooths and shows antibacterial capability against Escherichia coli ZnONPs [ 106 ] Antimicrobial/whitening ZnO NP toothpaste effectively degrade oral biofilm formed on tooth ZnONPs/F doped bioactive glass/TiO 2 Abrasion The restorative materials showed an insignificant difference in terms of micro-hardness before and after the treatment with all dentifrices SiO 2 /Chitosan [ 107 ] Increase retention time in oral mucosal surfaces Addition of Surface medicated SiO2 NPs with some material such as chitosan, phenylboronic acid, and acryloyl groups caused to toothpaste retain in oral cavity for longer time after toothbrushing Ca 2+ /PO 4 3− @Mesopore SiO 2 [ 108 ] Remineralization Ca 2+ /PO 4 3− @MSNs occlude tubules and sustained release Ca 2+ /PO 4 3− l -arginine-containing mesopore SiO 2 [ 109 ] Anti caries l -arginine released in a sustained way from Mesopore SiO 2 and diffused out from the dental adhesive, effectively contributing to the reduction of the bacteria. Ag NPs [ 110 ] Remineralization Ag NPs inhibit 100 % microorganism growth, Ag NPs promoted remineralization tooth enamel with initial caries-like lesion and bactericidal activity Ag NPs/calcium phosphate NPs [ 111 ] Anti biofilm/Remineralization Decreased biofilm viability and lactic ...…”

“…It has also been shown to have antimicrobial properties against different pathogens. It is frequently employed as an antimicrobial ingredient in tooth hygiene products such as toothpaste due to its high surface-to-volume ratio [ 104 ]. Shahawi compares the antibacterial impact of toothpaste containing 0.5 % and 1 % ZnO to that of a control group.…”

“…Shahawi compares the antibacterial impact of toothpaste containing 0.5 % and 1 % ZnO to that of a control group. Their findings suggest that the presence of zinc oxide NPs improves antibacterial activity, and toothpaste with a higher concentration of ZnO has a superior impact [ 104 ]. Additionally, Prasad and colleagues demonstrated that using zinc oxide/F toothpaste twice daily dramatically reduced oral microbiota content compared to fluoride-only toothpaste [ 187 ].…”