Background Dental caries is the most prevalent oral infection affecting the individuals worldwide, and Streptococcus mutans is the major microorganism involved in its pathology. Thus, the aim was to evaluate the antibacterial effect of addition of nanozinc particles on toothpaste with different concentrations. The study was carried out as Deburdent toothpaste was used as a control group, and nanozinc particles were added with different concentrations to the same toothpaste, and antibacterial test for each group was evaluated. Methods Group 1: (control group) toothpaste only. Group 2: 0.5% of nanozinc particles added to toothpaste. Group 3: 1% of nanozinc particles added to toothpaste. The three groups were incubated for 24 h at 37 °C, and the antibacterial test was tested for all groups using agar well diffusion method. Results All the samples had antibacterial effect against streptococcus mutans. Meanwhile, Group 3 has showed the greatest zone of inhibition compared to the control group showed the lowest effect. Conclusions One % of nanozinc particles were more efficient on Sterptoccocus mutans in comparison with 0.5% nanozinc particles concentration effect.

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