Incorporation of ZnO nanoparticles into heparinised polyvinyl alcohol/chitosan hydrogels for wound dressing application

Khorasani, Mohammad Taghi; Joorabloo, Alireza; Moghaddam, Armaghan; Shamsi, Hamidreza; Mansoori-Moghadam, Zohreh

doi:10.1016/j.ijbiomac.2018.04.010

Cited by 336 publications

(158 citation statements)

References 56 publications

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“…These characteristic peaks in the XRD pattern of CHI/AA/ZnO‐3 nanostructured hydrogel sponge indicated that ZnO particles were successfully loaded into CHI/AA sponge, supporting the SEM–EDS results. In addition, characteristic peaks of ZnO nanoparticles are not seen in the spectra of CHI/AA/ZnO‐1 and CHI/AA/ZnO‐2 hydrogel (data not shown) the reason of which may be the slight presence of ZnO in hydrogel structure …”

Section: Resultsmentioning

confidence: 98%

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Bal‐Öztürk

Karal-Yılmaz

Akgüner

et al. 2019

J of Applied Polymer Sci

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In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze‐drying technique. Genipin was used as a crosslinker. The prepared chitosan‐based sponges were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy—energy‐dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge‐like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like‐nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.

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Section: Resultsmentioning

confidence: 98%

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Bal‐Öztürk

Karal-Yılmaz

Akgüner

et al. 2019

J of Applied Polymer Sci

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“…To investigate the interaction between the components of the obtained hydrogel, the FTIR spectrums were obtained, which will characterize the formation of bonds and dynamic bonds in the hydrogel (Figure S4, Supporting Information). There were some characteristic peaks of PVA, such as hydroxyl peak with broad absorption peak (3446 cm −1 ), stretching vibration peak of CH (3030 cm −1 ), symmetric bending of CH 2 (1441 cm −1 ), and stretching vibration of CO (1196 cm −1 ) . Note that the position of some function groups changed when the CNDs was cross‐linking with PVA.…”

Section: Resultsmentioning

confidence: 99%

Poly(vinyl alcohol)–Carbon Nanodots Fluorescent Hydrogel with Superior Mechanical Properties and Sensitive to Detection of Iron(III) Ions

Shao

Wang

et al. 2019

Macro Materials & Eng

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A high‐strength fluorescent hydrogel is prepared by physical cross‐linking of carbon nanodots (CNDs) with poly(vinyl alcohol) (PVA). The stretching and compression of the PVA hydrogel are improved with CNDs by 176% and 64%, respectively. It still has excellent self‐healing behaviors without adding other healing agents. In addition, the search for rapid detection of heavy metals is still a huge challenge. The resulting hydrogel exhibits fluorescence quenching in the presence of Fe3+ by the fluorescence characteristics of CNDs, which has high selectivity and sensitivity. The PVA‐CNDs fluorescent hydrogel can be used as a solid detection platform for Fe3+, where the detection limit is found to be 10 µm for Fe3+ by fluorescence studies.

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“…In the functional group region, there was generally the following characteristic absorption peaks, such as OH absorption peak around 3200–3800 cm −1 . The FTIR spectrum of PVA mainly concentrated on the broad absorption peak of 3446 cm −1 wave number related to the hydroxyl group (OH) and the characteristic peak of 2942 cm −1 (CH extending), 1441 cm −1 (CH 2 bending), and 1096 cm −1 (CO extending) . Pure AG also showed several characteristic peaks, 1075 cm −1 indicated stretching vibration (CO), and 890 cm −1 represented 3,6‐hard‐galactose .…”

Section: Resultsmentioning

confidence: 99%

Self‐Healing Hydrogel of Poly (vinyl alcohol)/Agarose with Robust Mechanical Property

et al. 2019

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As promising soft materials, various excellent properties of hydrogels have received widespread attention during recent years. Mechanical properties and self‐healing performance are required characteristics for hydrogels in practical applications. An important challenge is to develop hydrogels exhibiting mechanical performance and self‐recoverability through physical cross‐linking. In this work, the authors report a hydrogel consisting of a fully physically linked poly (vinyl alcohol)/agarose (PVA/AG) dual‐network, which is of high toughness and self‐healing properties. The synthesis process of the PVA/AG hydrogel is convenient, with AG as the first network, and hydrogen bonding and crystal‐associated PVA as the second network to form a dual physical crosslink. Due to this physical cross‐linking, the PVA/AG hydrogel has good mechanical properties (tensile strength of 6.5 MPa to 14.6 MPa, ductility of 168% to 214%). The highest compressive strength of hydrogel is up to 3.66 MPa, which is almost 8 times that of pure PVA hydrogel. In addition, it has excellent self‐healing properties without stimulation or healing agents. Compared to pure PVA hydrogel, PVA/AG hydrogels have higher thermal stability due to higher decomposition temperatures and lower degradation rates. In this study, the authors also initially explore the potential application of obtained hydrogel.

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Incorporation of ZnO nanoparticles into heparinised polyvinyl alcohol/chitosan hydrogels for wound dressing application

Cited by 336 publications

References 56 publications

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Poly(vinyl alcohol)–Carbon Nanodots Fluorescent Hydrogel with Superior Mechanical Properties and Sensitive to Detection of Iron(III) Ions

Self‐Healing Hydrogel of Poly (vinyl alcohol)/Agarose with Robust Mechanical Property

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