Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Abstract

In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze‐drying technique. Genipin was used as a crosslinker. The prepared chitosan‐based sponges were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy—energy‐dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge‐like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like‐nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.

Biodegradable shape memory polymer foams with appropriate thermal properties for hemostatic applications

“…Bal‐Ozturk et al reported chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges that could be used as an antibacterial hemostat. ZnO in the sponges increased antibacterial properties, and the hydrogel sponge was biocompatible in vitro and in vivo (Bal‐Ozturk et al, ). Fathi et al () synthesized zeolite‐loaded alginate–chitosan hydrogel beads where zeolite served as blood absorbent.…”

“…Various forms (e.g., solid sheets, sponges, particles/fibers) of biomaterials (e.g., collagen, keratin, chitosan, polyurethane) have been investigated for use as an effective hemostat (Peng, 2010;Tomizawa, (CHI/AA/ZnO) nanostructured hydrogel sponges that could be used as an antibacterial hemostat. ZnO in the sponges increased antibacterial properties, and the hydrogel sponge was biocompatible in vitro and in vivo (Bal-Ozturk et al, 2019). Fathi et al (2018) synthesized zeolite-loaded alginate-chitosan hydrogel beads where zeolite served as blood absorbent.…”

Advancements and future directions in the antibacterial wound dressings – A review

“…In recent studies, the number of studies with metallic nanostructures increases due to concerns on antibiotic resistance. It is known that a variety of metals including silver, gold, copper, titanium, zinc oxide, iron oxide, and magnesium oxide have antibacterial activities, 31,32,84,85 and are widely used in design of novel wound dressing materials.…”

“…It is known that a variety of metals including silver, gold, copper, titanium, zinc oxide, iron oxide, and magnesium oxide have antibacterial activities, 31,32,84,85 and are widely used in design of novel wound dressing materials.…”

Chemie der Chitosan‐Aerogele: Lenkung der dreidimensionalen Poren für maßgeschneiderte Anwendungen

“…[200,201] SiO 2 ,ZrO 2 und TiO 2 werden ebenfalls zu diesem Zweck in Gerüstverbindungen und Perlkatalysatoren eingesetzt. [202,203] Anorganische Oxide dienen zur Funktionalisierung dieser Gerüste und Perlen, zum Beispiel ZnO füre ine antibakterielle und photokatalytische Aktivität, [204] TiO 2 fürp hotokatalytische und katalytische Aktivitäten, [205] Fe 3 O 4 ,u me ine Sammlung durch Magnetkräfte zu ermçglichen, [206] und Zeolithe zur Adsorption und als Strukturgerüste fürd ie Tr ocknung bei Umgebungsdruck. [180] Komposite mit lumineszierenden Materialien haben ein großes Potenzial fürs ensorische/bildgebende Anwendungen wie das Gas-responsive rotemittierende YVO 4 :Eu 3+ , [199] das IR-zu-vis-aufkonvertierende NaY-F 4 :Yb 3+ ,Er 3+ [207] sowie Eu 3+ -und Tb 3+ -Komplexe mit SiO 2 .…”