Increase in age at onset of giant cell arteritis: a population-based study

Kermani, Tanaz A.; Schäfer, Valentin Sebastian; Crowson, Cynthia S.; Hunder, Gene G.; Gabriel, Sherine E.; Matteson, Eric L.; Warrington, Kenneth J.

doi:10.1136/ard.2009.111005

Cited by 96 publications

(70 citation statements)

References 2 publications

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“…(15) There was a slight decrease from 79.3 years of age seen in 2000-04 to 77.1 in 2005-09. It is possible that the progressively increasing age trend at diagnosis has reached a plateau.…”

Section: Discussionmentioning

confidence: 96%

The incidence of giant cell arteritis in Olmsted County, Minnesota, over a 60-year period 1950–2009

Chandran

Udayakumar

Crowson

et al. 2015

Scandinavian Journal of Rheumatology

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Objective To assess the incidence of giant cell arteritis (GCA) in the current era (2000-2009). Methods We extended the previously identified population-based cohort of Olmsted County, MN residents who fulfill 1990 ACR criteria for GCA (1950-1999) for another decade. Results In 2000-2009, 74 cases of GCA were identified (mean age: 78.1 years; 80% women; 79% temporal artery biopsy positive; 7 included based on radiological criteria). The incidence of GCA was 19.8 per 100,000 population. Conclusions The GCA incidence rates have remained steady since 1970, and the age at incidence, which was progressively increasing, appears to have reached a plateau.

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“…(15) There was a slight decrease from 79.3 years of age seen in 2000-04 to 77.1 in 2005-09. It is possible that the progressively increasing age trend at diagnosis has reached a plateau.…”

Section: Discussionmentioning

confidence: 96%

The incidence of giant cell arteritis in Olmsted County, Minnesota, over a 60-year period 1950–2009

Chandran

Udayakumar

Crowson

et al. 2015

Scandinavian Journal of Rheumatology

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“…A cohort of patients with GCA diagnosed between 1950 and 2004 has already been established and previously described 18 19. All patients in this cohort met the 1990 American College of Rheumatology classification criteria for GCA 20.…”

Section: Methodsmentioning

confidence: 99%

Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis

et al. 2012

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Objectives To evaluate incidence trends and timing of large-vessel (LV) manifestations in patients with giant cell arteritis (GCA), and, to examine the influence of LV manifestations on survival. Methods A population-based incident cohort of patients diagnosed with GCA between 1950 and 2004 was used. LV involvement was defined as large artery stenosis or aortic aneurysm/dissection that developed in the 1 year prior to GCA diagnosis or any time thereafter. Patients were followed until death or December 31, 2009. Results The study included 204 patients, 80% women, mean age at diagnosis of GCA 76.0 years (± 8.2 years). Median length of follow-up was 8.8 years. The cumulative incidence of any LV manifestation at 10 years was 24.9% for patients diagnosed with GCA between 1980–2004 compared to 8.3% for patients diagnosed with GCA between 1950 and 1979. The incidence of any LV event was high within the first year of GCA diagnosis. The incidence of aortic aneurysm/dissection increased 5 years after GCA diagnosis. Compared to the general population, survival was decreased in patients with an aortic aneurysm/dissection (p<0.001) but not in patients with large-artery stenosis (p=0.11). Patients with GCA and aortic manifestations had higher than expected number of deaths from cardiovascular and pulmonary causes compared to the general population. Among patients with GCA, aortic manifestations were associated with increased mortality (HR: 3.4; 95% CI: 2.2, 5.4). Conclusions Screening for aortic aneurysms should be considered in all patients with GCA with vigilance 5 years after incidence. Aortic aneurysm/dissection is associated with increased mortality in GCA.

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“…По данным Т. Kermani и соавт. [18], средний возраст па-циентов, заболевших ГКА, составляет 76,7 года. Извест-но, что среди больных ИБС в возрасте 70-80 лет частота коморбидной патологии превышает 60%, при этом, как правило, присутствует несколько сопутствующих забо-леваний [19].…”

Section: Discussionunclassified

Experience With Tocilizumab, an Interleukin 6 Inhibitor, Used for the Treatment of Giant Cell Arteritis With Severe Comorbidity

Бекетова¹,

Ushakova²,

Никишина³

et al. 2018

rsp

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Increase in age at onset of giant cell arteritis: a population-based study

Cited by 96 publications

References 2 publications

The incidence of giant cell arteritis in Olmsted County, Minnesota, over a 60-year period 1950–2009

The incidence of giant cell arteritis in Olmsted County, Minnesota, over a 60-year period 1950–2009

Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis

Experience With Tocilizumab, an Interleukin 6 Inhibitor, Used for the Treatment of Giant Cell Arteritis With Severe Comorbidity

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