Increase in Cardiac Troponin I in a Lamb with Tetralogy of Fallot

Abstract

This study describes a case of tetralogy of Fallot in a lamb showing failure to thrive and signs of respiratory distress. Physical examination, electrocardiography, thoracic radiographies, echocardiography and cardiac troponin I evaluation were performed. The value of cardiac troponin I was compared with the values of 10 healthy lambs of the same age and breed, and the affected animal demonstrated an increase in cardiac troponin I. Due to the poor prognosis, euthanasia was indicated, and necropsy confirmed the diagnosis. This is the first report of an increase in cardiac troponin I in a lamb with tetralogy of Fallot.

Bacterial endocarditis and increased cardiac troponin I levels in a brown howler monkey (Alouatta guariba clamitans) with an interventricular septal defect

“…Although well described in humans, little is known about the increase in cTnI levels in cases of bacterial endocarditis and interventricular septal defect in non‐human primates. In veterinary medicine, an increase in cTnI levels has been reported in a bovine with infective endocarditis and in a lamb with tetralogy of Fallot . Congenital heart disease lead to hemodynamic changes, such as pressure and volume overloads, as well as abnormalities that may activate neurohormones, inflammatory cytokines, fibroblasts and vascular endothelial cells, contributing to cardiomyocyte damage .…”

Comparison of Two Commercially Available Immunoassays for the Measurement of Bovine Cardiac Troponin I in Cattle With Induced Myocardial Injury

“…Cardiac troponin I (cTnI) is a sensitive and specific biomarker for the detection of myocardial injury in humans. In recent years cTnI has been evaluated in ruminant species with cardiac diseases such as pericarditis ( 1 ), endocarditis ( 2 , 3 ), as well as in neonates with congenital cardiac defects ( 4 , 5 ), non-cardiac disorders ( 6 , 7 ), nutritional muscular dystrophy ( 8 , 9 ), myocarditis ( 10 – 12 ), umbilical abscessation ( 13 ), envenomation ( 14 ), pregnancy toxemia ( 7 , 15 , 16 ), ruminal acidosis ( 17 , 18 ), and endotoxemia ( 19 ). Similarly, infection with Theileria annulata in cattle is associated with increased circulating cTnI ( 20 ).…”