Increase in Endogenous Fibrinolysis and Platelet Activity during Exercise in Young Volunteers

Beisiegel, Bert; Treese, N; Häfner, Gerd; Meyer, J; Darius, Harald

doi:10.1007/978-3-0348-7262-1_25

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…However, the El-Sayed and De Jong studies involved mostly men, and the discordant fi ndings may thus be gender-related. Besiegel et al studied a group of young women during high-intensity, submaximal exercise on a cycle ergometer, and reported increases in plasma tPA activity that are nearly identical to the present study ( ~ 200 % increase) [6] .…”

Section: Discussion ▼supporting

confidence: 86%

“…These physiological responses suggest women with elevated body fat may be at increased risk of an adverse thrombosis-related event both at rest and during exercise compared to leaner women. tion factor VII and fi brinogen at rest [15,24] , and exhibit a smaller increase in fi brinolytic and coagulation potential than men in response to a high intensity bout of aerobic exercise [6] . Resistance exercise is gaining popularity as a form of recreational and therapeutic activity, but only one published study of the hemostatic responses to resistance exercise [13] included a single female subject.…”

Section: Introduction ▼mentioning

confidence: 99%

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The Influence of Acute Resistance Training and Body Composition on Coagulation and Fibrinolytic Activity in Low-Risk Women

Nagelkirk¹,

Scalzo²,

Harber³

et al. 2010

Int J Sports Med

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This study explored the coagulation and fibrinolytic responses to acute resistance training in young women and aimed to determine the influence of body composition on these variables. Healthy young women aged 23+/-5 yrs participated in the study. Body fat and fat distribution were assessed using DEXA. Each subject performed 6 sets of 10 leg extension repetitions at an intensity associated with 70% of 1-repetition maximum. Markers of coagulation (TAT), fibrinolytic stimulation (tPA) and inhibition (PAI-1) were assessed before and immediately after exercise. tPA activity increased in response to acute resistance exercise (p<0.05), however, there was no change in TAT or PAI-1 activity. Percent body fat was negatively correlated to the tPA response to exercise (r=-0.44), and positively related to PAI-1 at baseline (r=0.47) and post-exercise (r=0.47), and to post-exercise TAT (r=0.44). Android/gynoid fat ratio was negatively related to post-exercise tPA (r=-0.43), positively related to PAI-1 at baseline (r=0.61) and post-exercise (r=0.62) and to post-exercise TAT (r=0.43). These physiological responses suggest women with elevated body fat may be at increased risk of an adverse thrombosis-related event both at rest and during exercise compared to leaner women.

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Section: Discussion ▼supporting

confidence: 86%

Section: Introduction ▼mentioning

confidence: 99%

The Influence of Acute Resistance Training and Body Composition on Coagulation and Fibrinolytic Activity in Low-Risk Women

Nagelkirk¹,

Scalzo²,

Harber³

et al. 2010

Int J Sports Med

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“…Although physical activity is widely recognised as being beneficial to health, attempts to relate the effects of exercise to changes in platelet aggregation and functions have produced conflicting results. For example, some studies have reported that strenuous exercise results in increased platelet aggregation in response to adenosine diphosphate (ADP),f77-85] collagen [71,78,80,841 and adrenaline,f 74 1 Similarly, maximal cycling exerciseI76, 83,85] and maximal treadmill running! ?I] resulted in a significant activation of platelets as manifested by an increased sensitivity to ADPinduced aggregation, Radioimmunoassays of the plasma levels of ~-TG and platelet factor 4; plateletspecific proteins liberated from a-granules during activation, have been used as markers to assess the degree of platelet activation,186,87] Todd et al,l88] demonstrated a significant increase in platelet aggregability as reflected by an increase in plasma level of ~-TG in elderly men after treadmill exercise at 70 to 75% V02max, Other studies showed that strenuous exercise causes an increase in plasma level of ~_TGI16,18,66,76,81 ,84,[89][90][91][92][93] and platelet factor 4, [76,89,[93][94][95] Additional markers pertinent to platelet activation such as a-granule membrane protein [91] and thromboxane (TX) B2 were also increased after exercise,l88, 91,92] It has been suggested that exercise-induced activation of platelets might be linked with anaerobic metabolism for energy production during exercise.…”

Section: Platelet Count and Functionsmentioning

confidence: 99%

Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation

Elsayed

1996

Sports Medicine

144

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Disturbances of the haemostatic balance may result in thrombosis or bleeding tendency. There have been abundant reports on the effects of exercise on blood haemostasis, but the results reported have been conflicting and difficult to interpret. This review outlines and critically evaluates the relevant literature on the effects of short term exercise and physical training on the 3 systems of blood haemostasis i.e. blood coagulation, fibrinolysis and platelet aggregation. Short term exercise is usually associated with a significant shortening of activated partial thromboplastin time (APTT) and a marked increase in factor VIII (FVIII). The rise in FVIII is directly related to exercise intensity and the individuals' training status. Exercise also induces a significant increase in blood fibrinolysis which is dependent on exercise intensity, duration and training condition. The rise in blood fibrinolysis is mainly due to an increase in tissue-type plasminogen activator (t-PA) and a decrease in its main inhibitor plasminogen activator inhibitor (PAI-1) which are released from the endothelial cells of the vessel wall. Platelet count increases in exercise and this is probably due to a fresh release of platelets from the spleen, bone marrow and lungs. Studies on the effects of exercise on platelet aggregation and markers of platelet activation have produced conflicting results, and the exact effects of exercise remain as yet undetermined. It is suggested that short term exercise activates blood coagulation and enhances blood fibrinolysis and the delicate balance between clot formation and clot dissolution is maintained in normal populations. No valid conclusion could be reached regarding the actual effects of physical training on blood coagulation, fibrinolysis and platelet aggregation. This is undoubtedly due to variations in training programmes employed, populations studied, and the analytical methods used.

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“…Furthermore, in premenopausal women, concentrations of exhaled NO were found to be threefold higher in the middle of the menstrual cycle than at the end or the beginning, suggesting an influence of female sex hormones (13). In comparison to women, physical exercise in men led to a significant increase in platelet aggregation (40). In contrast, since gender differences in endothelium-dependent relaxations did not involve NO, other authors suggest that non-NO-dependent factors may contribute to the differences described between men and women (14).…”

Section: Discussionmentioning

confidence: 92%

Randomized, Placebo-controlled, Blinded and Cross-matched Study on the Antiplatelet Effect of Inhaled Nitric Oxide in Healthy Volunteers

Gries

Herr²,

Motsch³

et al. 2000

Thromb Haemost

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SummaryThe platelet inhibitory effect of 0-40 ppm inhaled nitric oxide (NO) was investigated in healthy men and women. In both groups, ADPand collagen-induced platelet aggregation was significantly inhibited 20 (T20) and 40 min (T40) after the beginning of inhalation of 5, 10, and 40 ppm. Moreover, in both men and women, the in vitro bleeding time was significantly prolonged at T20 and T40 during inhalation of 40 ppm. Inhalation of NO also inhibited P-selectin expression at 5, 10, and 40 ppm and fibrinogen binding to the GPIIb/IIIa-receptor at 40 ppm. In conclusion, in healthy volunteers, the platelet inhibitory effect of inhaled NO was not dose-related, since it was significant at 5 and 10 ppm but did not increase during the administration of higher NO concentrations. In addition, gender-related differences were only observed in ADP-induced platelet aggregation at 10 ppm and in bleeding time prolongation at 40 ppm.

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Increase in Endogenous Fibrinolysis and Platelet Activity during Exercise in Young Volunteers

Cited by 6 publications

References 3 publications

The Influence of Acute Resistance Training and Body Composition on Coagulation and Fibrinolytic Activity in Low-Risk Women

The Influence of Acute Resistance Training and Body Composition on Coagulation and Fibrinolytic Activity in Low-Risk Women

Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation

Randomized, Placebo-controlled, Blinded and Cross-matched Study on the Antiplatelet Effect of Inhaled Nitric Oxide in Healthy Volunteers

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