Increase in Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Had a Strong Impact on the Development of Type 2 Diabetes in Japanese Individuals with Impaired Insulin Secretion: The Saku Study

Morimoto, Akira; Tatsumi, Yukako; Soyano, Fumie; Miyamatsu, Naomi; Sonoda, Nao; Godai, Kayo; Ohno, Yuko; Noda, Minoru; Deura, Kijyo

doi:10.1371/journal.pone.0105827

Cited by 32 publications

(29 citation statements)

References 29 publications

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“…The HOMA-IR was used to determine IR on the basis of fasted insulin and glucose levels. Elevated HOMA-IR has a positive impact on the development of type 2 diabetes in patients with impaired insulin secretion (24). In the present study, it was demonstrated that Apelin-13 significantly reduced the elevated FPG, FINS and HOMA-IR.…”

Section: Discussionsupporting

confidence: 62%

Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet

Fang

2018

Mol Med Report

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Apelin has been reported to be associated with multiple physiological processes in the cardiovascular system. The aim of the present study was to investigate the effects of Apelin-13 administration on cardiac function, hyperglycemia, insulin resistance (IR), dyslipidemia, endothelial function, inflammation and glucose metabolism in type 2 diabetic Goto-Kakizaki (GK) rats, and compare the protective effects of Apelin-13 with metformin or atorvastatin. In the present study, type 2 diabetes was induced in male Goto-Kakizaki (GK) rats fed with high-fat diet (HFD). Simultaneously, the rats were treated with metformin (350 mg/kg/d, by gavage), atorvastatin (50 mg/kg/d, by gavage) or Apelin-13 (200 µg/kg/d, intraperitoneal injection) once daily for 4 consecutive weeks. Hemodynamic parameters were examined by RM6240BD multi-channel physiological signal monitoring. Fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis model assessment for insulin resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), endothelin-1 (ET-1), nitric oxide (NO), constitutive nitric oxide synthase (cNOS) activity, tumor necrosis factor-α (TNF-α), leptin and Apelin-12 levels were measured. Western blotting was performed to determine the levels of Apelin-12, glucose transporter 4 (GLUT4) and phosphorylated (p)-5'adenosine monophosphate-activated protein kinase (AMPK) α2. It was demonstrated that Apelin-13 decreased heart rate, left ventricular end-diastolic pressure, FPG, FINS, HOMA-IR, TC, TG, LDL-C, ET-1, TNF-α and leptin, whereas it increased the rise and fall of maximum rate of left ventricular pressure, HDL-C, NO, cNOS activity and Apelin-12 compared with the GK-HFD group. In addition, GLUT4 and p-AMPKα2 levels in myocardial tissues were elevated by administration of Apelin-13. This protective effect of Apelin-13 was comparable to that of metformin or atorvastatin. Overall, the present study demonstrated that administration ofApelin-13 may be a promising therapeutic agent for the treatment of type 2 diabetes and metabolic syndrome.

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Section: Discussionsupporting

confidence: 62%

Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet

Fang

2018

Mol Med Report

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“…As HOMA index is usually used to calculate insulin resistance in subjects with the metabolic syndrome without diabetes, or in those with diabetes without therapy, the use of HOMA-IR may be debatable in diabetic individuals. However, many studies (30)(31)(32)(33) have also demonstrated that HOMA-IR is significantly associated with diabetes.…”

Section: Limitationsmentioning

confidence: 99%

Low vitamin D levels and non-alcoholic fatty liver disease, evidence for their independent association in men in East China: a cross-sectional study (Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China))

et al. 2016

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Recent studies have suggested an association between vitamin D and non-alcoholic fatty liver disease (NAFLD); however, some results are subject to debate. This study was carried out to evaluate the correlation between NAFLD and vitamin D in men and women in East China. The data were obtained from a cross-sectional study that focused on the health and metabolic status of adults in sixteen areas of East China. According to ultrasonic assessments, the patients were divided into normal and NAFLD groups. Demographic characteristics and biochemical measurements were obtained. Binary logistic regression analysis was used to explore the association. In total, 5066 subjects were enrolled, and 2193 (43·3 %) were diagnosed with NAFLD; 84·56 % of the subjects showed vitamin D deficiency. Subjects with high vitamin D levels had a lower prevalence of NAFLD, particularly male subjects. Within the highest quartile of vitamin D levels, the prevalence of NAFLD was 40·8 %, whereas the lowest quartile of vitamin D levels showed a prevalence of 62·2 %, which was unchanged in women across the vitamin D levels. Binary logistic analysis showed that decreased vitamin D levels were associated with an increased risk of NAFLD (OR 1·54; 95 % CI 1·26, 1·88). This study suggests that vitamin D levels are significantly associated with NAFLD and that vitamin D acts as an independent factor for NAFLD prevalence, particularly in males in East China. Vitamin D interventional treatment might be a new target for controlling NAFLD; elucidating the mechanism requires further research.Key words: Vitamin D: Non-alcoholic fatty liver disease: BMI: Homoeostasis model assessment: Insulin resistance Non-alcoholic fatty liver disease (NAFLD), alternatively known as metabolic fatty liver disease, is associated with insulin resistance, dyslipidaemia, obesity and the metabolic syndrome (1) . In parallel with the obesity epidemic, NAFLD has become one of the most common causes of chronic liver disease in the world. Up to 30 % of adults are affected by NAFLD in America (2) . A study from China reported that the prevalence of NAFLD was as high as 20 % (3) . Vitamin D deficiency (VDD) can be a result of inadequate or limited exposure to sunlight, improper diet or problems related to absorption of vitamin D. Certain diseases can impair vitamin D conversion into its active form. Some of these conditions include kidney disease, liver disease or some hereditary diseases. VDD usually results in bad mineralisation of bones, leading to bone softening, osteomalacia, rickets and osteoporosis. As VDD is a risk factor for developing these metabolic deficiencies and has been linked to disorders in bone metabolism, more recent studies have suggested that obesity and visceral obesity occur with VDD. The potential association between VDD and NAFLD has been examined in recent studies. Mohamed et al. (4) reported that VDD is an important risk factor for NAFLD, and Kong et al.(5) observed that VDD might up-regulate endogenous fatty acid synthesis in non-alcoholic steatohep...

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“…The HOMA‐IR, the method for estimating the insulin resistance, has been commonly used in diabetes research for decades, and an increase of HOMA‐IR is intensely associated to the development of type 2 diabetes (Morimoto et al , ). Our experiment proved that the induction of type 2 diabetes caused by the elevation of HOMA‐IR, indicating the improvement of insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats

et al. 2015

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Lonicera japonica Thunb. (Caprifoliaceae) is a traditional herbal medicine and has been used to treat diabetic symptoms. Notwithstanding its use, the scientific basis on anti-diabetic properties of L. japonica is not yet established. This study is designed to investigate anti-diabetic effects of L. japonica in type 2 diabetic rats. L. japonica was orally administered at the dose of 100 mg/kg in high-fat diet-fed and low-dose streptozotocin-induced rats. After the treatment of 4 weeks, L. japonica reduced high blood glucose level and homeostatic model assessment of insulin resistance in diabetic rats. In addition, body weight and food intake were restored by the L. japonica treatment. In the histopathologic examination, the amelioration of damaged β-islet in pancreas was observed in L. japonica-treated diabetic rats. The administration of L. japonica elevated peroxisome proliferator-activated receptor gamma and insulin receptor subunit-1 protein expressions. The results demonstrated that L. japonica had anti-diabetic effects in type 2 diabetic rats via the peroxisome proliferator-activated receptor gamma regulatory action of L. japonica as a potential mechanism.

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Increase in Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Had a Strong Impact on the Development of Type 2 Diabetes in Japanese Individuals with Impaired Insulin Secretion: The Saku Study

Cited by 32 publications

References 29 publications

Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet

Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet

Low vitamin D levels and non-alcoholic fatty liver disease, evidence for their independent association in men in East China: a cross-sectional study (Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China))

Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats

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