Increase in interleukin-6 and fibrinogen in peripheral blood after swine dust inhalation

Abstract

Objectives The inhalation of dust from swine confinement buildings causes inflammatoly responses in the airways with a rise of interleukin-6 (IL-6). The purpose of this study was to confirm the increase in serum IL-6 after inhalation of swine dust and investigate a possible increase in plasma fibrinogen. Methods Eight healthy nonsmoking volunteers inhaled dust for 4 hours inside a swine confinement building. Inhalable dust and endotoxin were sampled. The collcentrations of IL-6 and fibrinogen were determined in serum and plasma. Results The study showed a clear increase in the concentrations of IL-6 and fibrinogen after exposure. C O~C~U S~O~S As fibrinogen is an important risk factor for ischemic heart disease, the increased concentration of fibrinogen among persons exposed to swine dust may increase the risk for this disease.

RE: Occupational endotoxin‐exposure and possible health effects on humans

“…Inhalation of dust containing endotoxin from a swine confinement building caused an inflammatory response in volunteers with an increase of fibrinogen by around 1 g/L [Sjögren et al, 1999]. However, inflammatory markers increased much less after exposure in swine farmers compared with the increase among previously non-exposed volunteers [Palmberg et al, 2002].…”

Oxidative stress in families of type 1 diabetic patients.

“…Indeed, the association between high Lp(a) serum levels and high plasma concentrations of the proinflammatory cytokine interleukin-6 (IL-6) suggested that genetic control of Lp(a) levels may be modulated by age and environmental factors, such as the chronic subclinical inflammatory process (25). Similarly, the concentrations of IL-6 and fibrinogen correlated (26)(27)(28). Thus, markers of cardiovascular risk are also acute-phase reactants (29).…”

Concentrated Swine Feeding Operations and Public Health: A Review of Occupational and Community Health Effects

“…rhusiopathiae. Disease associated with the pathogen E. rhusiopathiae has been recognized in swine occupations since the (97,104) Fibrinogen (106) 19th century (141)(142)(143). There are three human disease syndromes associated with this pathogen: a cutaneous form (erysipeloid), an acute or septicemic form, and a chronic form (141,143,144).…”