Increase in pertussis cases along with high prevalence of two emerging genotypes of Bordetella pertussis in Perú, 2012

Bailon, Henri; León-Janampa, Nancy; Padilla, Carlos; Hozbor, Daniela Flavia

doi:10.1186/s12879-016-1700-2

Cited by 18 publications

(15 citation statements)

References 39 publications

(38 reference statements)

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“…Paroxysmal cough and cyanosis were found to be the most frequent and statistically significant symptoms associated with confirmed cases of pertussis herein. However, stridor was not significant in our results, despite being commonly referred to in the literature [24,26].…”

Section: Plos Onecontrasting

confidence: 56%

“…Considering that non-specific symptoms of pertussis constitute a mandatory notification of a suspected case of pertussis, it is possible that this procedure could introduce bias into the classification of pertussis cases. Moreover, several studies have shown a higher frequency of pertussis in children aged one year or less, mainly those under six months, who present high numbers of hospitalizations and more frequent disease complications [1,13,[24][25][26][27].…”

Section: Plos Onementioning

confidence: 99%

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Clinical and epidemiological features of pertussis in Salvador, Brazil, 2011–2016

et al. 2020

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Pertussis, a severe respiratory infection caused by Bordetella pertussis, is distributed globally. Vaccination has been crucial to annual reductions in the number of cases. However, disease reemergence has occurred over the last decade in several countries, including Brazil. Here we describe the clinical and epidemiological aspects of suspected pertussis cases in Salvador, Brazil, and evaluate factors associated with case confirmation. This descriptive and retrospective study was conducted in the five hospitals in Salvador that reported the highest number of pertussis cases between 2011-2016. Demographic and clinical data were recorded for each patient. Bivariate analysis was performed to evaluate differences between groups (confirmed vs. unconfirmed cases) using Pearson's Chi-square test or Fisher's exact test. Results: Of 529 suspected pertussis cases, 29.7% (157/529) were confirmed by clinical, clinical-epidemiological or laboratory criteria, with clinical criteria most frequently applied (63.7%; 100/157). Unvaccinated individuals (43.3%; 68/157) were the most affected, followed by age groups 2-3 months (37.6%; 59/157) and <2 months (31.2%; 49/ 157). Overall, �50% of the confirmed cases presented a complete vaccination schedule. All investigated cases presented cough in association with one or more symptoms, especially paroxysmal cough (66.9%; 105/529) (p = 0.001) or cyanosis (66.2%; 104/529) (p<0.001). Our results indicate that pertussis occurred mainly in infants and unvaccinated individuals in Salvador, Brazil. The predominance of clinical criteria used to confirm suspected cases highlights the need for improvement in the laboratory tools used to perform rapid diagnosis. Fluctuations in infection prevalence demonstrate the importance of vaccination strategies in improving the control and prevention of pertussis.

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Section: Plos Onecontrasting

confidence: 56%

Section: Plos Onementioning

confidence: 99%

Clinical and epidemiological features of pertussis in Salvador, Brazil, 2011–2016

et al. 2020

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“…Remarkably, cgMLST was much more discriminant than PFGE or MLVA, 2 reference epidemiologic typing methods, which appeared unable to distinguish related intrafamilial isolates or isolates collected from the same patient from cocirculating unrelated ones. PFGE and MLVA are widely used and will likely continue to be used until WGS is largely implemented ( 29 – 32 ), especially in settings in which WGS cannot be achieved because of cost considerations. Our work provides a correspondence between whole-genome–based phylogenetic data and both PFGE and MLVA genotypes and thus provides essential information for the accurate interpretation of typing data from these legacy typing methods.…”

Section: Discussionmentioning

confidence: 99%

Genomic Sequencing of Bordetella pertussis for Epidemiology and Global Surveillance of Whooping Cough

Bouchez¹,

Guglielmini²,

Dazas³

et al. 2018

Emerg. Infect. Dis.

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Bordetella pertussis causes whooping cough, a highly contagious respiratory disease that is reemerging in many world regions. The spread of antigen-deficient strains may threaten acellular vaccine efficacy. Dynamics of strain transmission are poorly defined because of shortcomings in current strain genotyping methods. Our objective was to develop a whole-genome genotyping strategy with sufficient resolution for local epidemiologic questions and sufficient reproducibility to enable international comparisons of clinical isolates. We defined a core genome multilocus sequence typing scheme comprising 2,038 loci and demonstrated its congruence with whole-genome single-nucleotide polymorphism variation. Most cases of intrafamilial groups of isolates or of multiple isolates recovered from the same patient were distinguished from temporally and geographically cocirculating isolates. However, epidemiologically unrelated isolates were sometimes nearly undistinguishable. We set up a publicly accessible core genome multilocus sequence typing database to enable global comparisons of B. pertussis isolates, opening the way for internationally coordinated surveillance.

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“…In the last decade, several countries reported an increase of pertussis cases, including Australia, the Netherlands, Spain, Japan, Canada, the USA, Peru and Brazil [11,[14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Emerging ofptxP3 lineage inBordetella pertussis strains circulating in a population in northeastern Mexico

et al. 2018

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We determined the molecular epidemiology of Bordetella pertussis isolates to evaluate its potential impact on pertussis reemergence in a population of Mexico. Symptomatic and asymptomatic cases were included. Pertussis infection was confirmed by culture and real-time polymerase chain reaction (PCR). Selected B. pertussis isolates were further analysed; i.e. clonality was analysed by pulsed-field gel electrophoresis (PFGE) and ptxP-ptxA, prn, fim2 and fim3 typing was performed by PCR and sequencing. Out of 11 864 analysed samples, 687 (5.8%) were positive for pertussis, with 244 (36%) confirmed by both culture and PCR whereas 115 (17%) were positive only by culture and 328 (48%) were positive only by PCR. One predominant clone (clone A, n = 62/113; 55%) and three major subtypes (A1, A2 and A3) were identified by PFGE. All 113 selected isolates had the allelic combination ptxP3-ptxA1. The predominant clone A and the three major subtypes (A1, A2 and A3) corresponded to the emerging genotypes ptxP3-ptxA1-prn2-fim2-1-fim3-2 and ptxP3-ptxA1-prn2-fim2-1-fim3-1. In conclusion, the presence of an endemic clone and three predominant subtypes belonging to the genotypes ptxP3-ptxA1-prn2-fim2-1-fim3-2 and ptxP3-ptxA1-prn2-fim2-1-fim3-1 were detected. This finding supports the global spread/expansion reported for these outbreaks associated genotypes.

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Increase in pertussis cases along with high prevalence of two emerging genotypes of Bordetella pertussis in Perú, 2012

Cited by 18 publications

References 39 publications

Clinical and epidemiological features of pertussis in Salvador, Brazil, 2011–2016

Clinical and epidemiological features of pertussis in Salvador, Brazil, 2011–2016

Genomic Sequencing of Bordetella pertussis for Epidemiology and Global Surveillance of Whooping Cough

Emerging ofptxP3 lineage inBordetella pertussis strains circulating in a population in northeastern Mexico

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