Increase in serum cholesterol during phenytoin treatment.

Pelkonen, R; Fogelholm, R; E, Nikkilä

doi:10.1136/bmj.4.5988.85

Cited by 55 publications

(34 citation statements)

References 4 publications

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“…The results in our study findings are similar to those other investigations done by P Kumar et al, Pelkonen et al, Nikkila et al, and Luoma et al, also reported same findings i.e. an increase in TG, LDL-C and HDL-C levels in epileptic patients on long-term treatment with Phenytoin [5][6][7][8].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry

Manimekala¹

2014

JCDR

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Introduction: Several studies have reported that commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum High Density Lipoproteins Cholesterol (HDL-C) levels, while some others documented no such effect. Further, some researchers also observed that valproic acid and other newer antiepileptic drugs like lamotrigine and levetiracetam has no influence on serum lipid profile. The present study was planned to assess and compare serum lipid profile of young adult patients on commonly used antiepileptic drugs (phenytoin, oxcarbazepine and valproic acid) and newer antiepileptic drug (levetiracetam) attending Neurology OPD of a tertiary care hospital in Puducherry, India compared to normal subjects. Materials and Methods:A prospective hospital based crosssectional study was conducted in Tertiary care hospital. Epileptic patients attending Department of Neurology and taking antiepileptic drugs for last six months or more and on regular follow up; approximately 60 patients on commonly used antiepileptic drugs (20 on phenytoin, 20 on oxcarbazepine, 20 on valproic Acid) and 20 patients on newer antiepileptic drug (levetiracetam) was included in the study. Age and sex matching 80 controls were taken. Statistical analysis:Descriptive statistics explained using mean ± SD. Inferential statistics was used depending on the nature of variables. We used one-way-ANOVA and followed by independent t-test for comparison with control group and statistically significant was considered at p-value <0.05.

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Section: Discussionsupporting

confidence: 92%

Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry

Manimekala¹

2014

JCDR

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“…Potential confounders considered in the analysis included: weight, which is associated with cholesterol level (Kahn et al, 1969) and possibly with inguinal hernia (Zimmerman & Anson, 1967;Abramson et al, 1978); region of birth, which is associated with cholesterol level (Kahn et al, 1969;Halfon et al, 1982a) and with brain tumours (Israel Cancer Registry, 1982); social class which has been shown to be inversely associated with cholesterol levels in a Jerusalem study population and possibly with central nervous system tumour incidence (Preston-Martin et al, 1982;Registrar General, 1971); season of the year (Harlap et al, 1982b) and smoking (Goldbourt & Medalie, 1977;Halfon et al, 1982b; which are apparently associated with cholesterol; and use of the drugs diphenylhydantoin, barbiturates or glucocorticoids which has been shown to be associated with higher cholesterol levels (Nikkila et al, 1978;Pelkonen et al, 1975 …”

Section: Methodsmentioning

confidence: 99%

Serum cholesterol and primary brain tumours: A case-control study

Abramson¹,

Kark²

1985

Br J Cancer

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In recent years, there has been considerable interest in the study of the relationship of serum cholesterol with cancer incidence and mortality (Hlatky & Hulley, 1981; Levy, 1982; Feinleib, 1983;McMichael et al., 1984). A number of studies have shown an inverse association in men, though usually not in women, whereas in other reports there was no relationship. The most consistent (inverse) association was for cancer of the colon. Two population-based prospective studies in Israel, the Kiryat Hayovel Community Health Study in Jerusalem and the Israel Ischemic Heart Disease Study showed higher levels of serum cholesterol (with mean differences of about 20 mg dl-1 and 16 mg dl1 respectively) in the small numbers (5 and 17 respectively) of subjects who died of intracranial tumours during follow-up (Kark et al. and Goldbourt et al., unpublished observations). A small case-control comparison showed substantially higher serum cholesterol levels in 7 hospitalized brain tumour patients than in hospitalized controls with a variety of debilitating diseases (Basu et al., 1974).The objective of our study was to test the hypothesis that a positive relationship exists between high levels of serum cholesterol and primary brain tumours (including meningeal tumours). Subjects and methodsA case-control study was performed based on the hospital records of male Jewish residents of Israel [20][21][22][23][24], and of 10 years at older ages) and year of hospitalization. For two cases, controls were found only from the subsequent year. The controls for each case were chosen randomly from

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“…Studies on anticonvulsants have demon strated elevated serum cholesterol and triglycer ide levels in healthy subjects and patients with epilepsy (4,12,16). High plasma HDL choles terol levels have been measured in subjects undergoing phenytoin treatment (15).…”

Section: Introductionmentioning

confidence: 99%

Plasma High-Density Lipoprotein Cholesterol in Epileptics Treated with Various Anticonvulsants

et al. 1980

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Plasma high-density lipoprotein (HDL) cholesterol in 97 epileptics on long-term anticonvulsant therapy was investigated. Therapy with phenytoin alone or in combination with carbamazepine or phenobarbital was associated with elevated plasma HDL cholesterol levels as compared with controls. HDL cholesterol in patients treated with carbamazepine did not diverge from control values. Patients treated with phenytoin and phenobarbital in combination showed higher HDL cholesterol levels than those treated with phenytoin alone. There was an inverse correlation between the HDL cholesterol and serum triglyceride levels. The results demonstrate that high plasma HDL cholesterol might be associated with therapy involving some anticonvulsants known to be potent enzyme inducers. This suggests that the elevation of HDL cholesterol during therapy is probably related to the drug-caused enzyme induction phenomenon.

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Increase in serum cholesterol during phenytoin treatment.

Abstract: Increase in serum cholesterol during phenytoin treatment Long-term treatment with phenytoin is often accompanied by various metabolic and endocrine abnormalities. Particular attention has been

Cited by 55 publications

References 4 publications

Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry

Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry

Serum cholesterol and primary brain tumours: A case-control study

Plasma High-Density Lipoprotein Cholesterol in Epileptics Treated with Various Anticonvulsants

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