Increase in the threshold of a nociceptive test induced by naloxone in morphine-tolerant rats

Kayser, V.; Guilbaud, G.

doi:10.1016/0006-8993(85)90815-7

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…The results of these two experiments establish that following a regimen of injections of morphine, which is effective in inducing morphine tolerance and leads to withdrawal (Kayser & Guilbaud, 1985), rats reduce their intake of (Experiments 1) and preference for (Experiment 2) sweet solutions. Experiment 1 demonstrated that Mor rats consumed less saccharin, but not less water, than Sal rats at 17 hr after the last injection.…”

Section: Discussionmentioning

confidence: 68%

“…In this first experiment, intake of saccharin was measured during the early period of morphine withdrawal (a 24-hr period, beginning 17 hr after the last morphine injection). Using a morphine administration procedure similar to the one used in this study, rats were shown to be completely tolerant to the analgesic effects of morphine at this period (Kayser & Guilband, 1985). In a preliminary experiment, we found that with the same procedure, tolerance to the analgesic effects of morphine disappears by the 8th day after the last morphine injection (Lieblich & Yirmiya, 1986).…”

Section: Methodsmentioning

confidence: 99%

“…Morphine treatment was a modification of a procedure that was previously found to induce morphine tolerance (Kayser & Guilbaud, 1985). Morphine sulphate in isotonic saline (40 mg/ml sc) was injected daily for 5 days.…”

Section: Methodsmentioning

confidence: 99%

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Intake of and preference for sweet solutions are attenuated in morphine-withdrawn rats.

Lieblich¹,

Yirmiya²,

Liebeskind³

1991

Behavioral Neuroscience

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The hypothesis that intake of sweet solutions is partially controlled by endogenous opioid peptides was tested in 2 experiments that examined the effects of repetitive morphine administration and withdrawal on subsequent intake of and preference for saccharin solutions in rats. Experiment 1 established that 17 hr after morphine withdrawal, rats consumed less saccharin, but not less water, than did controls. The groups did not differ 8 days later. In Experiment 2, using a 2-bottle saccharin-preference test, rats exhibited a reduced preference to saccharin solutions (1, 3, 9, 30, or 60 mM) for 6 days after morphine withdrawal. The difference between the groups was most pronounced at the most preferred concentrations (9 and 30 mM). The results suggest that cross-tolerance occurs between morphine and the opioid-mediated hedonic effects of sweet solutions.

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Section: Discussionmentioning

confidence: 68%

Section: Methodsmentioning

confidence: 99%

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Intake of and preference for sweet solutions are attenuated in morphine-withdrawn rats.

Lieblich¹,

Yirmiya²,

Liebeskind³

1991

Behavioral Neuroscience

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“…The search for new pharmacologic treatments for these conditions continues (5–9), but preclinical evaluation of their effectiveness has lagged behind. The predictive ability of current techniques used to assess drug effectiveness remains approximate because they are based on reflex (10–12) or pseudo‐affective (13, 14) reactions to acute or subacute painful stimuli in animals, which have limited relevance to predictability in humans. Investigators have attempted to identify specific behaviors as markers of discomfort generated by pain (paw position [15], weight load on each leg [16], gait analysis [17], or locomotion [18]).…”

mentioning

confidence: 99%

Circadian pattern of spontaneous behavior in monarthritic rats: A novel global approach to evaluation of chronic pain and treatment effectiveness

Millecamps¹,

Jourdan²,

Leger³

et al. 2005

Arthritis & Rheumatism

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Objective. Preclinical evaluation is an essential step in the assessment of new antiinflammatory or analgesic drugs. This study was undertaken to develop a new mode of evaluation of drug effectiveness based on behavior indicating well-being in a rat model of chronic inflammatory pain. We chose to examine the circadian pattern of spontaneous behavior.Methods. The work was performed with a model of chronic monarthritis induced by Freund's complete adjuvant. Variations in behavioral patterns during the time course of arthritis were analyzed. In a second phase, the impact of acetaminophen and 2 nonsteroidal antiinflammatory drugs (aspirin and celecoxib), which are currently used in clinical practice to treat chronic inflammation, was studied after 7 days of treatment.Results. The nocturnal pattern of activity of healthy rats comprised 3 main bursts. Chronic painful monarthritis altered this spontaneous pattern of nocturnal behavior (normal period of activity). Monarthritic rats showed a decrease in the total time spent in activity during the night, and lost their pattern of activity. These behavioral disturbances were reversed after long-term treatment with acetaminophen or celecoxib, with celecoxib appearing to be more effective. Aspirin was ineffective.Conclusion. These results enabled us to test this new procedure as a means of assessing well-being or illbeing during stages of chronic inflammatory pain in rats, and the effectiveness of repeated pharmacologic treatments.Arthritis and other rheumatic conditions are among the most common chronic diseases: they affected 70 million US adults in 2001, and are the major cause of disability among US adults (60% of US population older than 65 years) (1). These conditions are characterized by persistent inflammatory pain, which is treated with nonsteroidal antiinflammatory drugs or corticosteroids (2). However, long-term use of these drugs induces numerous gastrointestinal side effects (3,4), and their real impact on patient quality of life remains uncertain.The search for new pharmacologic treatments for these conditions continues (5-9), but preclinical evaluation of their effectiveness has lagged behind. The predictive ability of current techniques used to assess drug effectiveness remains approximate because they are based on reflex (10-12) or pseudo-affective (13,14) reactions to acute or subacute painful stimuli in animals, which have limited relevance to predictability in humans. Investigators have attempted to identify specific behaviors as markers of discomfort generated by pain (paw position [15], weight load on each leg [16], gait analysis [17], or locomotion [18]). However, there is only putative evidence that they may be of use in pharmacologic studies since they adopt a functional approach to disease rather than constituting a real evaluation of spontaneous pain.Many clinical studies on pain are based on genSupported by a grant from the Association pour la Recherche sur la Poly-arthrite.

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Analgesia produced by low doses of the opiate antagonist naloxone in arthritic rats is reduced in morphine-tolerant animals

1986

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Increase in the threshold of a nociceptive test induced by naloxone in morphine-tolerant rats

Cited by 10 publications

References 26 publications

Intake of and preference for sweet solutions are attenuated in morphine-withdrawn rats.

Intake of and preference for sweet solutions are attenuated in morphine-withdrawn rats.

Circadian pattern of spontaneous behavior in monarthritic rats: A novel global approach to evaluation of chronic pain and treatment effectiveness

Analgesia produced by low doses of the opiate antagonist naloxone in arthritic rats is reduced in morphine-tolerant animals

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