Increase in tuberculin skin test converters among health care workers after a change from Tubersol to Aplisol

Gillenwater, Kari A.; Sapp, Sandra C.; Pearce, Kim R.; Siberry, George K.

doi:10.1016/j.ajic.2006.05.288

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Most reports comparing the two preparations found a higher number of positive reactions when the Aplisol preparation was used (1,4,12). The population found to be Aplisol positive but Tubersol negative ranged from 1.0% (1) to 1.4% (4) of the population tested, much lower than that observed here.…”

Section: Discussioncontrasting

confidence: 52%

Differences in Tuberculin Reactivity as Determined in a Veterans Administration Employee Health Screening Program

Mehta

MacGruder

Looney

et al. 2009

Clin Vaccine Immunol

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Section: Discussioncontrasting

confidence: 52%

Differences in Tuberculin Reactivity as Determined in a Veterans Administration Employee Health Screening Program

Mehta

MacGruder

Looney

et al. 2009

Clin Vaccine Immunol

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“…1 In addition, in some studies TST reactivity has varied between tuberculin supplied by different manufacturers and Pelly and others (2005) used Tubersol, whereas Getchell and others (1992) and our current study both used Aplisol. [45][46][47][48] In conclusion, despite recent reductions in reported rates of TB disease, TST positivity rates are still high in these shantytowns, especially among those 25 years of age and older. The TST positivity in the 15-24 age group decreased since 1990 probably at least partially because multiple BCG vaccinations (that cause false positive TST) were common, and have now become rare.…”

Section: Discussionmentioning

confidence: 99%

Changes in Tuberculin Skin Test Positivity Over 20 Years in Periurban Shantytowns in Lima, Peru

Martínez

Arman

Haveman

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract.A cross-sectional, community-based study was performed in 2012 with 428 residents of periurban shantytowns in Lima, Peru to study risk factors for and changes in latent tuberculosis infection in age-stratified groups compared with our data from the same region in 1990 (N = 219) and 2005 (N = 103). Tuberculin skin test positivity in these communities was highly prevalent at 52% overall, increased with age (P 0.01) and was similar to 2005 (53%) and 1990 (48%). From 1990 to 2012, the prevalence of tuberculin positivity decreased in 5-14 and 15-24 year old groups (to 17% and 34%, respectively, both P 0.05). However, this may be explained by cessation of Bacille Calmette-Guérin revaccination during this period, because Bacille Calmette-Guérin revaccination doubled tuberculin positivity. Over the same 22-year period, tuberculin positivity in the 25 year old group remained high (71%, P = 0.3), suggesting that prevalent latent tuberculosis infection persists in the adult population despite improving medical care and socioeconomic development in this region.

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“…The results of skin testing with Aplisol ® and Tubersol ® are quite comparable with that of the original PPD standard, PPD‐S (Villarino et al ., ). However, shifting use from Tubersol ® to Aplisol ® , or vice‐versa, has resulted in skin test aberrations, although the exact reason is still unclear (Gillenwater et al ., ; Mehta et al ., ).…”

Section: Past and Present Use Of Ppdmentioning

confidence: 99%

Purified protein derivatives of tuberculin — past, present, and future

Yang

Kruh-Garcia

Dobos

2012

FEMS Immunol Med Microbiol

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The tuberculin skin test, which involves monitoring the immune reaction to an injection of purified protein derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Proteomic evaluation of PPD combined with a detailed analysis in the guinea pig model of tuberculosis led to further definition of the molecular composition of PPD. This communication reviews the history and current status of PPD, in addition to describing candidate next‐generation PPD reagents, based on the use of an individual protein or protein cocktails.

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Increase in tuberculin skin test converters among health care workers after a change from Tubersol to Aplisol

Cited by 8 publications

References 12 publications

Differences in Tuberculin Reactivity as Determined in a Veterans Administration Employee Health Screening Program

Differences in Tuberculin Reactivity as Determined in a Veterans Administration Employee Health Screening Program

Changes in Tuberculin Skin Test Positivity Over 20 Years in Periurban Shantytowns in Lima, Peru

Purified protein derivatives of tuberculin — past, present, and future

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