Increase of cervical adenocarcinoma: A report of 520 cases of cervical carcinoma including 112 tumors with glandular elements

Glandular Lesions of the Uterine Cervix

“…Although older studies suggested that the prognosis for typical adenocarcinomas was worse than that for squamous cervical cancer, more recent studies that adjusted for depth, stage, and therapy generally have not identified a significant difference (23,40).…”

“…An absolute as well as a relative increase in the incidence of adenocarcinoma of the cervix has occurred in the United States during the past 20 years (23)(24)(25). The relative frequency of adenocarcinoma is now approximately 15 to 20% of all invasive cervical carcinomas.…”

Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix

“…[1][2][3][4] The Papanicolaou smear has the potential to serve as an important screening mechanism in the prevention of CVCA because there is a well recognized precursor lesion that is accessible to sampling devices currently in use with cytologically distinctive features and a relatively long progression time to invasive adenocarcinoma. 16,31 Nevertheless, compared with squamous lesions, AIS smears have been shown to have a significantly higher interpretive false-negative rate, 21 and Papanicolaou smears have not been effective in the prevention of adenocarcinoma.…”

“…The diagnostic false-negative or false-unsatisfactory rate in reviewed smears was 50% T he relative and absolute incidences of cervical adenocarcinoma (CVCA) are increasing. [1][2][3][4] Because of the existence of an in situ precursor lesion (adenocarcinoma in situ [AIS]) with increasingly well defined cytological features, 5-13 the Papanicolaou smear is potentially a powerful test in preventing CVCA. Nevertheless, Papanicolaou smear screening has been less effective in detecting CVCA than it has been in detecting cervical squamous carcinoma.…”

Tumor de colisión de cérvix uterino: presentación de 17 casos

“…Se ha demostrado que las células basales de la unión escamocolumnar funcionan como células de reserva y que pueden dar origen, durante eventos reparativos, a epitelio escamoso o columnar (3,(5)(6)(7)(8)(9)(10)(11)15), y a su vez, ante condiciones adversas del medio, como eventos cancerígenos específicos como la infección por VPH (8,15), estimulación hormonal del embarazo (14), dar origen a sus contrapartes tumorales, carcinoma escamocelular y adenoacarcinomas (3,(5)(6)(7)(8)(9)(10)(11), esto se correlaciona con la alta incidencia de la coexistencia de alteraciones de tipo displásico en eventos invasores de uno u otro tipo (8)(9)(10)(11)(12)(13)(14)(15). La importancia de este tipo de tumor está relacionado con un peor pronóstico para las pacientes en relación directa al mayor grado tumoral de las lesiones invasoras (7,13,15,16). No existen revisiones recientes acerca de las características epidemiológicas de los TCC.…”