Increase of frontal cerebral blood volume during transcranial magnetic stimulation in depression is related to treatment effectiveness: A pilot study with near‐infrared spectroscopy

Shinba, Toshikazu; Kariya, Nobutoshi; Matsuda, Saori; Matsuda, Hanae; Obara, Yusuke

doi:10.1111/pcn.12680

Cited by 26 publications

(20 citation statements)

References 26 publications

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“…However, this work establishes a precedent for functional targeting of TMS therapy using fNIRS-measured activity during tasks which have been identified as affected in a given disorder. Together with the recently published work by Shinba et al (2018), these studies make a compelling case that the ability or inability of excitatory rTMS to evoke hemodynamic activity may serve to inform clinical status and predict treatment response to TMS therapies.…”

Section: Effects Of Rtms Stimulation On Task-evoked Fnirs Activitymentioning

confidence: 84%

“…Most recently, a clinical pilot study conducted by Shinba et al (2018), reported significant increases in midline [HbO] during 10 Hz rTMS stimulation at 120%RMT to the left-DLPFC (5.5 cm anterior to M1) for treatment of drug-resistant individuals with MDD. Over the course of a 6-week treatment regime, the authors observed that the continued presence of [HbO] increase in response to stimulation was associated with clinical improvement as described by the Montgomery-Asberg Depression Rating Scale (MARDRS).…”

Section: Effects Of Tms Stimulation On Fnirs Measures At Restmentioning

confidence: 99%

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A Systematic Review of Integrated Functional Near-Infrared Spectroscopy (fNIRS) and Transcranial Magnetic Stimulation (TMS) Studies

et al. 2019

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Background: The capacity for TMS to elicit neural activity and manipulate cortical excitability has created significant expectation regarding its use in both cognitive and clinical neuroscience. However, the absence of an ability to quantify stimulation effects, particularly outside of the motor cortex, has led clinicians and researchers to pair noninvasive brain stimulation with noninvasive neuroimaging techniques. fNIRS, as an optical and wearable neuroimaging technique, is an ideal candidate for integrated use with TMS. Together, TMS+fNIRS may offer a hybrid alternative to “blind” stimulation to assess NIBS in therapy and research. Objective: In this systematic review, the current body of research into the transient and prolonged effects of TMS on fNIRS-based cortical hemodynamic measures while at rest and during tasks are discussed. Additionally, studies investigating the relation of fNIRS to measures of cortical excitability as produced by TMS-evoked Motor-Evoked-Potential (MEP) are evaluated. The aim of this review is to outline the integrated use of TMS+fNIRS and consolidate findings related to use of fNIRS to monitor changes attributed to TMS and the relationship of fNIRS to cortical excitability itself. Methods: Key terms were searched in PubMed and Web-of-Science to identify studies investigating the use of both fNIRS and TMS. Works from Google-Scholar and referenced works in identified papers were also assessed for relevance. All published experimental studies using both fNIRS and TMS techniques in the study methodology were included. Results: A combined literature search of neuroimaging and neurostimulation studies identified 53 papers detailing the joint use of fNIRS and TMS. 22/53 investigated the immediate effects of TMS at rest in the DLPFC and M1 as measured by fNIRS. 21/22 studies reported a significant effect in [HbO] for 40/54 stimulation conditions with 14 resulting an increase and 26 in a decrease. While 15/22 studies also reported [HbR], only 5/37 conditions were significant. Task effects of fNIRS+TMS were detailed in 16 studies, including 10 with clinical populations. Most studies only reported significant changes in [HbO] related measures. Studies comparing fNIRS to changes in MEP-measured cortical excitability suggest that fNIRS measures may be spatially more diffuse but share similar traits. Conclusion: This review summarizes the progress in the development of this emerging hybrid neuroimaging & neurostimulation methodology and its applications. Despite encouraging progress and novel applications, a lack of replicated works, along with highly disparate methodological approaches, highlight the need for further controlled studies. Interpretation of current research directions, technical challenges of TMS+fNIRS, and recommendations regarding future works are discussed.

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Section: Effects Of Rtms Stimulation On Task-evoked Fnirs Activitymentioning

confidence: 84%

Section: Effects Of Tms Stimulation On Fnirs Measures At Restmentioning

confidence: 99%

A Systematic Review of Integrated Functional Near-Infrared Spectroscopy (fNIRS) and Transcranial Magnetic Stimulation (TMS) Studies

et al. 2019

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“…Their discoveries suggested that NIRS signals would be useful in evaluating social functioning in patients afflicted by late-onset depression (prior to treatment) and predicting the improvement in their social functioning after treatment. Furthermore, fNIRS can be used to predict the treatment response of not only antidepressants but also other novel treatments, such as neurostimulation (50,85,89), music therapy (49), and animal-assisted therapy (83).…”

Section: Use Of Fnirs To Monitor Treatment Responsementioning

confidence: 99%

Diagnostic and Predictive Applications of Functional Near-Infrared Spectroscopy for Major Depressive Disorder: A Systematic Review

et al. 2020

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Introduction: Major depressive disorder (MDD) is a global psychiatric disorder with no established biomarker. There is growing evidence that functional near-infrared spectroscopy (fNIRS) has the ability to aid in the diagnosis and prediction of the treatment response of MDD. The aim of this review was to systematically review, and gather the evidence from existing studies that used fNIRS signals in the diagnosis of MDD, correlations with depression symptomatology, and the monitoring of treatment response. Methods: PubMed, EMBASE, ScienceDirect, and Cochrane Library databases were searched for published English articles from 1980 to June 2019 that focused on the application of fNIRS for (i) differentiating depressed versus nondepressed individuals, (ii) correlating with depression symptomatology, and in turn (iii) monitoring treatment responses in depression. Studies were included if they utilized fNIRS to evaluate cerebral hemodynamic variations in patients with MDD of any age group. The quality of the evidence was assessed using the Newcastle-Ottawa quality assessment scale. Results: A total of 64 studies were included in this review, with 12 studies being longitudinal, while the rest were cross-sectional. More than two-thirds of the studies (n = 49) had acceptable quality. fNIRS consistently demonstrated attenuated cerebral hemodynamic changes in depressed compared to healthy individuals. fNIRS signals have also shown promise in correlating with individual symptoms of depression and monitoring various treatment responses. Conclusions: This review provides comprehensive updated evidence of the diagnostic and predictive applications of fNIRS in patients with MDD. Future studies involving larger

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“…Two recent meta-analyses collecting data from eight RCTs each one, (263 patients) [132] and (249 patients) [133], show major evidence for the beneficial effect of this form of rTMS in the treatment of MDD. These studies conclude that LF-rTMS (1 Hz) to the right DLPFC provides clinically meaningful benefits that are comparable to those of standard antidepressants and HF-rTMS [118] with fewer side effects [133].…”

Section: Low Frequency Rtms Versus High Frequency Rtmsmentioning

confidence: 72%

“…A later study showed that changes in frontal cerebral blood volume, measured as frontal hemoglobin concentration during TMS, are correlated with clinical outcomes of treatment [118].…”

Section: Dr Isaac Túnezmentioning

confidence: 99%

Effects and Therapeutic Use of TMS in Psychiatric Disorders: An Evidence-Based Review

Bm¹,

Fern²,

Fj³

et al. 2019

Neuropsychiatry

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ObjectiveRecently we found that chronic immobilization stress (CIS) induced low levels of glutamate (Glu) and glutamine (Gln) and hypoactive glutamatergic signaling in the mouse prefrontal cortex (PFC), which was closely related with Glu-Gln cycle. Moreover, Gln-supplemented diet ameliorated CISinduced deleterious changes. In the present study, therefore, we investigated the effects of CIS and Gln supplementation on Glu-Gln cycle-related proteins to understand underlying mechanisms. MethodsUsing CIS-induced depression mouse model, we confirmed depressive behaviors caused by CIS and antidepressant property of Gln-supplementation with behavioral test and blood corticosterone assay. We examined expression of eleven proteins involving Glu-Gln cycle in the PFC. ResultsCIS decreased glutamate transporter 1 (GLT1), sodium-coupled neutral amino acid transporter (SNAT) 3, SNAT5, and mature SNAT2, suggesting excitotoxicity in synaptic cleft and shortage of Glu and Gln in astrocytes and neurons. Gln-supplementation did not affect non-stressed group, but significantly increased SNAT1 and SNAT3, which are the major Gln transporter in neurons and astrocytes respectively, as well as the mature SNAT2, implicating increasing transportation of Gln into neurons. ConclusionAs a result, we confirmed that CIS disturbed Glu-Gln cycle toward shortage of Glu and Gln levels in astrocytes and neurons, but Gln supplementation changed Glu-Gln cycle toward facilitating translocation of Gln into neurons for glutamatergic signaling. Moreover, these results also supported the antidepressant property of Gln.

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Increase of frontal cerebral blood volume during transcranial magnetic stimulation in depression is related to treatment effectiveness: A pilot study with near‐infrared spectroscopy

Abstract: These results suggest that the maintenance of frontal activation during stimulation in the course of TMS series is related to the effectiveness in the treatment of depression. Measurement of fHbC during stimulation is informative in the clinical use of TMS.

Cited by 26 publications

References 26 publications

A Systematic Review of Integrated Functional Near-Infrared Spectroscopy (fNIRS) and Transcranial Magnetic Stimulation (TMS) Studies

A Systematic Review of Integrated Functional Near-Infrared Spectroscopy (fNIRS) and Transcranial Magnetic Stimulation (TMS) Studies

Diagnostic and Predictive Applications of Functional Near-Infrared Spectroscopy for Major Depressive Disorder: A Systematic Review

Effects and Therapeutic Use of TMS in Psychiatric Disorders: An Evidence-Based Review

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