Increase of Renal Cell Carcinoma Incidence in Central Europe

Wunderlich, Heiko; Schumann, S.; Jantitzky, V.; Morávek, P; Podhola, Miroslav; Kosmehl, Hartwig; Schubert, Jörg

doi:10.1159/000019652

Cited by 57 publications

(34 citation statements)

References 7 publications

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“…It is expected that the slowly growing and indolent tumors are likely to remain undetected along the patients' life; the real frequency of such lesions could be assessed by autopsy studies only. We [4] and the others [7,14,16,18,20,21] have shown previously that the relative frequency of conventional (clear cell) carcinomas is much lower in such material and the frequency of papillary tumors (carcinomas and papillomas) is much higher than in surgical series. Our previous study was biased in a way, as we considered anatomopathological post-mortem material.…”

Section: Discussionmentioning

confidence: 99%

“…Some interesting information about the epidemiology of cancer may be obtained from unselected autopsy material. Although anatomopathological autopsies are most frequently analyzed [4], it is difficult to regard them as entirely unselected; this is the why we decided to analyze forensic autopsies [7,[14][15][16][17][18][19][20]. Renal tumors are highly heterogeneous.…”

Section: Discussionmentioning

confidence: 99%

“…While the overall number of renal tumors detected at autopsy decreased, the frequency of incidental renal carcinomas remained constant. Wunderlich et al [20] analyzed frequency of necropsy-detected RCC in two Central-European regions, and found frequency of 1.76 and 1.55%, respectively. They found certain increase in frequency of incidental RCC and this increase paralleled the increase in the clinically evident RCC.…”

Section: Discussionmentioning

confidence: 99%

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Renal tumors in unselected forensic post-mortem material

Rzepecka-Woźniak¹,

Trzepla²,

Okoń³

2014

pjp

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The frequency of clinically evident renal tumors is increasing, due to an actual increase in incidence, but also due to an improvement in detection methods. The aim of the present study was to analyze the incidence of renal tumors in an unselected autopsy series. A search for renal tumors was conducted based on the autopsy reports from the Department of Forensic Medicine. The slides were reviewed and reclassified according to current criteria. Among 14,904 autopsies, 80 renal tumors were found. The most frequent tumor types were clear cell carcinomas (41%), papillary carcinomas (18%) and cortical adenomas (19%). There were 66 males and 14 females. The average age was 57.83 for males and 62.86 for females. The characteristics of the study group were not exactly identical but similar to other autopsy series, and significantly different from surgical series.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Renal tumors in unselected forensic post-mortem material

Rzepecka-Woźniak¹,

Trzepla²,

Okoń³

2014

pjp

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“…RCC is the third most common genitourinary neoplasm in the USA and the Netherlands with an increasing incidence in the last decade [3, 4]. Between 1989 and 1992 the total number of reported new cases of RCC increased from 1,287 to 1,438 in the Netherlands [5, 6].…”

Section: Discussionmentioning

confidence: 99%

Increase in Incidental Renal Cell Carcinoma in the Northern Part of the Netherlands

2000

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“…Renal cell carcinoma (RCC) detection was performed using noninvasive abdominal imaging techniques, which included: ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Pathological Grade and Gender are Predictors of Small Renal Cell Carcinoma Growth

Sugimoto¹

2014

J Integr Oncol

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Objective: This study was undertaken to investigate the clinicopathological factors that influence the growth of a small renal mass (SRM) in patients subjected to a delayed surgery intervention. Methods:We reviewed the clinical records of 37 patients with SRM 4 cm at diagnosis, who underwent delayed surgical intervention during surveillance from January 2000 to December 2013. Radiographic evaluation using computed tomography (CT) scan, magnetic resonance imaging (MRI) were performed at least every 6 months and the tumor size was determined at least twice.Results: Histopathological analysis revealed that in 35 of the 37 patients the tumor was malignant in stage pT1aN0M0. There were 28 clear cell carcinomas and 7 non clear cell carcinomas. There was a significant difference in the time to tumor doubling (TTD) among clear cell carcinomas (p=0.033). There was also a significant difference in the tumor growth rate (mm/year) of clear cell carcinomas between male and female patients (p=0.028). Conclusion:The growth rate of small renal mass was slow in the majority of our patients. Pathological grade and gender significantly influenced the growth of clear cell carcinomas.

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Increase of Renal Cell Carcinoma Incidence in Central Europe

Cited by 57 publications

References 7 publications

Renal tumors in unselected forensic post-mortem material

Renal tumors in unselected forensic post-mortem material

Increase in Incidental Renal Cell Carcinoma in the Northern Part of the Netherlands

Pathological Grade and Gender are Predictors of Small Renal Cell Carcinoma Growth

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