Increase of the Ejaculatory Potency by the Systemic Administration of Aqueous Crude Extracts of Cihuapatli (<i>Montanoa</i> Genus) Plants in Spinal Male Rats

Carro‐Juárez, Miguel; Franco, Miguel Ángel; Rodríguez-Peña, María de Lourdes

doi:10.1177/2156587213510006

Cited by 13 publications

(14 citation statements)

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“…Similarly, the pro ejaculatory effects of Montanoa frutescens and Montanoa grandiflora (Asteraceae) have been published (Carro-Juarez et al. 2014 ).…”

Section: Discussionmentioning

confidence: 89%

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Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D ₁ , D ₂ -like receptors

Defo

Asongu

Wankeu

et al. 2017

Pharmaceutical Biology

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Context:Guibourtia tessmannii (Caesalpiniaceae) is a plant traditionally used as aphrodisiac. We previously reported the pro-ejaculatory effects of the aqueous and methanol extracts of G. tesmannii in spinal male rat. However, the mechanism underlying such effects has not been elucidated.Objective: This study characterizes the dopaminergic sub-type receptors involved in G. tesmannii-induced ejaculation in male Wistar rat.Materials and methods: Urethane-anesthetized spinal male rats were intravenously treated with saline solution (1 mL/kg, control); dopamine (0.1 μmol/kg, reference); aqueous or methanol extracts of G. tesmannii (20 mg/kg) in the absence or presence of haloperidol (0.26 μmol/kg), a nonspecific dopaminergic receptor antagonist, Sch23390 (0.26 μmol/kg), a specific D1-like receptor antagonist or, sulpiride (0.26 μmol/kg), a specific D2-like receptor antagonist. Electromyography of the bulbospongiosus muscles and intraseminal pressure were recorded after urethral, penile and drug stimulations.Results: Urethral and penile stimulations, intravenous injection of dopamine or, aqueous and methanol extracts of G. tesmannii always triggered the expression of rhythmic contraction of the bulbospongiosus muscles with an average mean of 3.33 ± 0.43; 7.83 ± 0.85; 9.80 ± 0.86; 0.83 ± 0.54 and 2.67 ± 0.95 contractions, respectively. The intraseminal pressure was more expressed after urethral and penile stimulations (15.66 ± 1.58 and 13.60 ± 2.40 mmHg, respectively). In rats pretreated with haloperidol, Sch23390 or sulpiride, no ejaculation was recorded after intravenous injection of G. tesmannii extracts or dopamine.Discussion and conclusion:Guibourtia tesmannii-induced ejaculation requires the integrity of D1 and D2-like receptors. These findings further justify the ethno-medicinal claims of G. tesmannii as an aphrodisiac.

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“…Similarly, the pro ejaculatory effects of Montanoa frutescens and Montanoa grandiflora (Asteraceae) have been published (Carro-Juarez et al. 2014 ).…”

Section: Discussionmentioning

confidence: 89%

“… 2014 ) whereas cihuapatli ( Montanoa genus) increase the ejaculatory potency in spinal male rats (Carro-Juarez et al. 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D ₁ , D ₂ -like receptors

Defo

Asongu

Wankeu

et al. 2017

Pharmaceutical Biology

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“…Cihuapatli is the common name assigned to some plants of the genus Montanoa (family: Asteraceae; tribe: Heliantheae), in which M. frutescens and M. grandiflora are included (Rodríguez‐Landa et al., ). Carro‐Juárez, Franco, and Rodríguez‐Peña Mde () investigated comparative aphrodisiac activity of M. grandiflora and M. frutescens using the fictive ejaculation model in spinal male rats. They reported that systemic administration of the aqueous crude extracts of Montanoa plants elicited significant increase in the ejaculatory capacity of spinal male rats with very robust ejaculatory motor patterns that included the expression of tonic penile erections and penile movements and the potent expulsion of urethral contents.…”

Section: Medicinal Plants Andplant‐derived Products Used As Aphrodisimentioning

confidence: 99%

“…In another study, Carro‐Juárez et al. () found that the cihuapatli extract acts directly at the male rat spinal system in charge of the expression of the ejaculatory motor patterns; it is suggested that the aqueous crude extract exerts its aphrodisiac properties by increasing sexual potency acting as an oxytocic agent.…”

Section: Medicinal Plants Andplant‐derived Products Used As Aphrodisimentioning

confidence: 99%

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

Malviya¹,

Malviya²,

Jain³

et al. 2016

Andrologia

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Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human being's life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction.

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“…12 – 14 Preclinical studies, however, also show that the Montanoa tomentosa , Montanoa frutescens , and Montanoa grandiflora crude extracts facilitates expression of sexual behavior and increase the ejaculatory potency in male rats, suggesting a potent aphrodisiac effect that involves a positive motivational state. 15 , 16 The extract of Montanoa frutescens produced anxiolytic-like effects similar to diazepam in male Wistar rats, through the modulation of γ-aminobutyric acid-A (GABA A ) receptors. 17 Similar anxiolytic-like effects can be observed in rats during metestrus-diestrus phase of the ovarian cycle treated with Montanoa grandiflora and Montanoa frutescens extracts.…”

mentioning

confidence: 99%

The Aqueous Crude Extracts of Montanoa frutescens and Montanoa grandiflora Reduce Immobility Faster Than Fluoxetine Through GABA_A Receptors in Rats Forced to Swim

Rodríguez‐Landa

Cueto‐Escobedo

Flores-Aguilar

et al. 2018

J Evid Based Complementary Altern Med

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Background. Montanoa frutescens and Montanoa grandiflora have been indistinctly used for centuries in traditional Mexican medicine for reproductive impairments, anxiety, and mood disorders. Preclinical studies support their aphrodisiac and anxiolytic properties, but their effects on mood are still unexplored.Methods.The effects of 25 and 50 mg/kg of M frutescens and M grandiflora extracts were evaluated on days 1, 7, 14, 21, and 28 of treatment, and compared with fluoxetine (1 mg/kg) and Remotiv (7.14 mg/kg) in Wistar rats. The participation of GABAA receptor in the effects produced by the treatments was explored.Results. Montanoa extracts reduced immobility since day 1 of treatment, while fluoxetine and Remotiv required 14 days. The GABAA antagonism blocked the effects of Montanoa extracts, but not of fluoxetine or Remotiv.Conclusions. Montanoa extracts prevented quickly the stress-induced behaviors in the swimming test through action at the GABAA receptor, exerting a protective effect different to the typical antidepressants drugs.

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Increase of the Ejaculatory Potency by the Systemic Administration of Aqueous Crude Extracts of Cihuapatli (Montanoa Genus) Plants in Spinal Male Rats

Cited by 13 publications

References 25 publications

Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D ₁ , D ₂ -like receptors

Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D ₁ , D ₂ -like receptors

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

The Aqueous Crude Extracts of Montanoa frutescens and Montanoa grandiflora Reduce Immobility Faster Than Fluoxetine Through GABA_A Receptors in Rats Forced to Swim

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Increase of the Ejaculatory Potency by the Systemic Administration of Aqueous Crude Extracts of Cihuapatli (Montanoa Genus) Plants in Spinal Male Rats

Cited by 13 publications

References 25 publications

Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D 1 , D 2 -like receptors

Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D 1 , D 2 -like receptors

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

The Aqueous Crude Extracts of Montanoa frutescens and Montanoa grandiflora Reduce Immobility Faster Than Fluoxetine Through GABAA Receptors in Rats Forced to Swim

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Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D ₁ , D ₂ -like receptors

Guibourtia tessmannii -induced fictive ejaculation in spinal male rat: involvement of D ₁ , D ₂ -like receptors

The Aqueous Crude Extracts of Montanoa frutescens and Montanoa grandiflora Reduce Immobility Faster Than Fluoxetine Through GABA_A Receptors in Rats Forced to Swim