Increased Activation and Oligoclonality of Peripheral CD8<sup>+</sup>T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis

Manfras, Burkhard; Reuter, Stefan; Wendland, Thomas; Kern, Peter

doi:10.1128/iai.70.3.1168-1174.2002

Cited by 34 publications

(27 citation statements)

References 41 publications

(40 reference statements)

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“…The same issue applies to invariant NKT and MAIT cells, which are restricted to nonpolymorphic antigen-presenting molecules and recognize evolutionarily conserved antigens. Oligoclonality is a hallmark of the T-cell populations resident in epithelia and the intestine 23,35,36 , and a skewed peripheral T-cell repertoire is present in chronic infections [37][38][39] , autoimmune diseases 40,41 and cancer [42][43][44] .…”

Section: Discussionmentioning

confidence: 99%

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

et al. 2014

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Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize conserved bacterial antigens derived from riboflavin precursors, presented by the nonpolymorphic MHC class I-like molecule MR1. Here we show that human MAIT cells are remarkably oligoclonal in both the blood and liver, display high inter-individual homology and exhibit a restricted length CDR3b domain of the TCRVb chain. We extend this analysis to a second sub-population of MAIT cells expressing a semi-invariant TCR conserved between individuals. Similar to 'conventional' MAIT cells, these lymphocytes react to riboflavin-synthesizing microbes in an MR1-restricted manner and infiltrate solid tissues. Both MAIT cell types release Th0, Th1 and Th2 cytokines, and sCD40L in response to bacterial infection, show cytotoxic capacity against infected cells and promote killing of intracellular bacteria, thus suggesting important protective and immunoregulatory functions of these lymphocytes.

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Section: Discussionmentioning

confidence: 99%

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

et al. 2014

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“…A large number of CD4(+) T lymphocytes are present in AE patients with aborted or dead lesions, whereas patients with active parasites display a significant increase in activation of predominantly CD8(+) T cells (Manfras et al, 2002) indicating that CD4(+) T cells may play a role in the killing mechanism. This is supported by experiments undertaken with genetically modified mice (Dai et al, 2001).…”

Section: T Cell Responsesmentioning

confidence: 99%

Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis

Zhang¹,

Li²,

Lin³

et al. 2012

Serological Diagnosis of Certain Human, Animal and Plant Diseases

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“…A large number of CD4 ϩ T lymphocytes are present in AE patients with aborted or dead lesions, whereas patients with active parasites display a significant increase in activation of predominantly CD8 ϩ T cells (37), indicating that CD4 ϩ T cells may play a role in the killing mechanism. This is supported by experiments undertaken with genetically modified mice (38).…”

Section: Adaptive Immunitymentioning

confidence: 99%

Mechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development

Zhang

Ross

McManus

2008

The Journal of Immunology

129

116

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The Echinococcus organisms, the cause of echinococcosis (hydatid disease), are parasitic helminths with life cycles involving a carnivorous definitive host (usually dog or fox) and an intermediate host (human, ungulate, or rodent). They are complex multicellular pathogens that, despite being under constant barrage by the immune system, are able to modulate antiparasite immune responses and persist and flourish in their mammalian hosts. Understanding how the immune system deals with these parasites is a major challenge. Recent application of modern molecular and immunological approaches has revealed insights on the nature of immune responses generated during the course of hydatid infection, although many aspects of the Echinococcus-host interplay remain unexplored. This review summarizes current understanding of the immunology of echinococcosis, indicates areas where information is lacking, and shows how knowledge of host protective immunity has been translated into the design and development of anti-Echinococcus vaccines for application in intermediate hosts.

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Increased Activation and Oligoclonality of Peripheral CD8⁺T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis

Abstract: Alveolar echinococcosis (AE) in humans is

Cited by 34 publications

References 41 publications

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis

Mechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development

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Increased Activation and Oligoclonality of Peripheral CD8+T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis

Abstract: Alveolar echinococcosis (AE) in humans is

Cited by 34 publications

References 41 publications

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis

Mechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development

Contact Info

Product

Resources

About

Increased Activation and Oligoclonality of Peripheral CD8⁺T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis